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EC number: 237-834-1 | CAS number: 14017-41-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
- Speijers (1982): LD50 (combined male and female rats): 766 mg/kg bw (95 % confidence interval: 677 - 867 mg/kg bw)
- Llobet, Domingo (1983): LD50: 537 mg/kg (Confidence interval: 479 – 601 mg/kg bw)
Read-across from soluble cobalt substances (i.e., cobalt dichloride and cobalt sulfate) and sodium sulfamate to cobalt(2 +) disulfamate is performed. A detailed documentation on read-across is attached on IUCLID section 13 (CoSulf_Read Across Assessment Framework Report).
Sodium sulfamate:
The LD50 of the substance in the female Wistar strain rat was estimated to be greater than 2500 mg/kg bodyweight (OECD 423).
Soluble cobalt substances:
The references Speijers (1982) and Llobet, Domingo (1983) are considered as the key studies for acute oral toxicity and will be used for classification. Female/male rats were dosed at 500, 600, 720, 864, 1137 mg/kg bw orally via gavage and at 350, 392, 450, 518, 595, 684, 787mg/kg orally via gavage respectively. During the conduct of the study mortalities occurred, thus the following LD50 values were derived:
Using the lowest LD50 value for cobalt dichloride hexahydrate (537 mg/kg bw) and the value for sodium sulfamate (2500 mg/kg bw), considering a cobalt content of 23.47% and a sulfamate content of 76.53% in cobalt(2 +) disulfamate, the calculated LD50 value for cobalt(2 +) disulfamate using the ATE formula given in ECHA guidance document R.7a resulted in an LD50 of 387.4 mg cobalt(2 +) disulfamate/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 387.4 mg/kg bw
- Quality of whole database:
- Reliable studies performed with cobalt dichloride hexahydrate and sodium sulfamate are available. Since read-across is performed and considered fully justified no studies should be initiated with cobalt(2+) disulfamate.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Acute toxicity, oral:
The classification criteria according to regulation (EC) 1272/2008 as acutely toxic category 4 are met since the ATE is above 300 mg/kg body-weight and below 2,000 mg/kg body-weight. Cobalt(2 +) disulfamate will be classified as acutely toxic category 4 (H302).
Specific target organ toxicant (STOT) – single exposure: oral
The classification criteria according to regulation (EC) 1272/2008 as specific target organ toxicant (STOT) – single exposure, oral are not met since the toxic effects observed in the acute oral toxicity test already leads to an acute oral toxicity classification. No additional effects in animals or humans are known that would justify a specific target organ toxicant (STOT) – single exposure: oral classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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