Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 221-359-1 | CAS number: 3077-12-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Refer to the analogue approach justification provided in IUCLID section 13.
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Validity criteria fulfilled:
- yes
- Conclusions:
- Based on the available read-across data, it is concluded that the target substance does not cause any visible or lethal effects in carp up to the analytically confirmed concentration of 100 mg/L (NOEC). The LC50 (96 h) exceeds 100 mg/L.
- Executive summary:
The short-term toxicity of the source substance Accelartor (PT 25 E or PT 25E/2) was assessed according to OECD guideline 203. In a static limit test, carp (Cyprinus carpio) were exposed to Accelerator (PT 25E or PT 25E/2) at the nominal concentration of 0 (blank-control) and 100 mg/L for 96 h. After 96 h, Accelerator (PT 25E or PT 25E/2) induced no visible or lethal effects in carp at an analytically confirmed concentration of 100 mg/L. The 96h-LC50 exceeded 100 mg/L based on analytically confirmed exposure concentrations. The study is considered to be reliable without restrictions.
The target substance is expected to have a similar ecotoxicological profile as the source substance based on the high degree of structural and chemical similarity between the source and the target substances. Therefore, it is concluded that the target substance does not cause any visible or lethal effects in carp up to a nominal concentration of 100 mg/L. The LC50 (96 h) exceeded 100 mg/L.
Reference
Description of key information
LC50 (96 h) > 100 mg/L (nominal, OECD 203, C. carpio); read-across
Key value for chemical safety assessment
Additional information
There is no guideline study available, in which the short-term toxicity of the target substance N,N-Dihydroxyethyl-p-toluidine (CAS 3077-12-1) to fish was assessed. Therefore, read-across to the structurally and chemically closely related source substance Reaction mass of 2,2'-[(4-methylphenyl)imino]bisethanol and Ethanol 2-[[2-(2-hydroxyethoxy)ethyl](4-methylphenyl)amino]- (EC 911-490-9) was performed in accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5 in order to meet the standard information requirements laid down in Annex VIII of REACh Regulation (EC) No 1907/2006. Based on the high degree of physico-chemical similarity between the target and source substance, the selected source substance is considered a suitable representative for the assessment of the short-term toxicity of the target substance to fish. A detailed read-across approach justification is provided in IUCLID section 13.
By means of the read-across approach one key study is available for the source substance (reliability 1, according to Klimisch score) and an additional supporting study with the target substance itself (reliability 4, according to Klimisch score due to insufficient documentation).
In the available study with the source substance, a static limit test according to OECD guideline 203 was performed, in which carp (Cyrpinus carpio) were exposed to a limit concentration of 100 mg/L for 96 h. A negative control was run in parallel and test item concentrations in the test vessels were analytically verified. After 96 h, no visible or lethal effects were observed at the analytically confirmed test item concentration of 100 mg/L, resulting in an LC50 (96 h) of > 100 mg/L.
This result is confirmed by the available supporting study with the target substance itself where no toxicity to fish was recorded after an exposure of 96 h up to a concentration of 100 mg/L.
Based on the high degree of structural and chemical similarity between the target and the source substance and since the target substance is the main constituent of the source substance, the target substance is expected to exhibit a similar ecotoxicological profile as the selected source substance. Therefore, it is concluded that the target substance N,N-Dihydroxyethyl-p-toluidine (CAS 3077-12-1) does not cause acute toxic effects to fish up to a nominal concentration of 100 mg/L. This is further confirmed by the available study for the target substance itself.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.