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Diss Factsheets
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EC number: 216-768-7 | CAS number: 1663-39-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Carcinogenicity
Administrative data
Description of key information
Based on results of the analogue n-butyl acrylate, tert-butyl acrylate is not anticipated to be carcinogenic in Spargue-Dawley rats via inhalation (doses up to 135 ppm (0.773 mg/L/day)). In addition, no evidence of carcinogenicity was found in a lifelong skin painting study with n-butyl acrylate in and in C4H/HeJ mice by dermal exposure at approx. 8 mg/kg bw.
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via inhalation route
Link to relevant study records
- Endpoint:
- carcinogenicity, other
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please find the attached justification.
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Dose descriptor:
- NOAEC
- Remarks:
- rat inhalation
- Effect level:
- >= 0.773 mg/L air (analytical)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- histopathology: neoplastic
- Remarks on result:
- other: Result read-across source CAS No. 141-32-2.
- Remarks:
- Correction for molecular weight is not required.
- Key result
- Dose descriptor:
- NOAEL
- Remarks:
- mice dermal
- Effect level:
- >= 8 mg/kg bw/day
- Based on:
- test mat.
- Remarks:
- applied 3 times a week
- Sex:
- male
- Basis for effect level:
- histopathology: neoplastic
- Remarks on result:
- other: Result read-across source CAS No. 141-32-2.
- Remarks:
- Correction for molecular weight is not required.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEC
- 773 mg/m³
- Study duration:
- chronic
- Species:
- rat
- Quality of whole database:
- Study performed equivalent to OECD 453 and under GLP conditions
Carcinogenicity: via dermal route
Link to relevant study records
- Endpoint:
- carcinogenicity, other
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please find the attached justification.
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Dose descriptor:
- NOAEC
- Remarks:
- rat inhalation
- Effect level:
- >= 0.773 mg/L air (analytical)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- histopathology: neoplastic
- Remarks on result:
- other: Result read-across source CAS No. 141-32-2.
- Remarks:
- Correction for molecular weight is not required.
- Key result
- Dose descriptor:
- NOAEL
- Remarks:
- mice dermal
- Effect level:
- >= 8 mg/kg bw/day
- Based on:
- test mat.
- Remarks:
- applied 3 times a week
- Sex:
- male
- Basis for effect level:
- histopathology: neoplastic
- Remarks on result:
- other: Result read-across source CAS No. 141-32-2.
- Remarks:
- Correction for molecular weight is not required.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 8 mg/kg bw/day
- Study duration:
- chronic
- Species:
- mouse
- Quality of whole database:
- Acceptable study report which meets basic scientific principles and performed under GLP conditions.
Justification for classification or non-classification
Based on the available data, classification as a carcinogen is not warranted in accordance with EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation No. 1272/2008 and GHS classification (GHS UN rev.6, 2015).
Additional information
No adequate animal data are available and no epidemiological studies or case reports of tert-butyl acrylate were identified. However, data from the structural analogue n-butyl acrylate are available.
In a 2-year inhalation study, Sprague-Dawley rats were exposed by whole body exposure 6 hours per day, 5 days a week to 0, 15, 45 or 135 ppm (corresponding to approx. 0, 0.086, 0.258, 0.773 mg/L/day) n-butyl acrylate. During the first 13 weeks of the study, the concentrations were lower: 0, 5, 15 or 45 ppm. The post observation period was 6 months. n-Butyl acrylate showed no carcinogenic effect up to the highest concentration tested of 135 ppm (0.773 mg/L/day) (BASF 1985).
In addition, a lifetime dermal carcinogenesis study was conducted in mice. The dermal carcinogenic potential of n-butyl acrylate was assessed by applying 25 µL of a 1% (v/v) dilution in acetone (corresponding to approx. 8 mg/kg bw) to the backs of 40 male C3H/HeJ mice. A negative control group receiving acetone was dosed simultaneously. Both applications were performed three times a week throughout the lifetime of the animals. No biologically significant skin tumours were observed in the group tested with acetone or in the n-butyl acrylate group. No signs of skin irritation were observed in this study. No significant difference in mortality rate was observed between the treated group and the acetone control group. n-Butyl acrylate was not carcinogenic when applied to the skin of C3H/HeJ mice throughout their lifetime.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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