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EC number: 204-246-1 | CAS number: 118-33-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation:
Skin irritation test of test chemical 6-aminonaphthalene-1,3-disulfonic acid (CAS No: 118-33-2) was conducted on rabbit to examine the degree of skin irritancy caused by the chemical. The rabbits were exposed to 2 mg of chemical dermally for 24 hours and later observed for skin reactions. Since the chemical induce sever skin reactions,6-amino-1,3- Naphthalene disulfonic acid(CAS No: 118-33-2) was considered to be irritating to rabbits’ skin.
Eye irritation:
The eye irritation potential of 6-amino-1,3- Naphthalene disulfonic acid (CAS No: 118-33-2) was assessed in rabbits. 750 µg of 6-amino-1,3- Naphthalene disulfonic acid was instilled into rabbit eyes and observed for signs of irritation till 24 hours. 6-amino-1,3- Naphthalene disulfonic acid was severely irritating to rabbit eyes after 24 hours of exposure. Hence, 6-amino-1,3- Naphthalene disulfonic acid (CAS No: 118-33-2) can be considered to be an eye irritant.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from RTECS and peer reviwed journal.
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Skin irritation test of test chemical 6-aminonaphthalene-1,3-disulfonic acid (CAS No: 118-33-2) was conducted on rabbit to examine the degree of skin irritancy caused by the chemical.
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material: 6-aminonaphthalene-1,3-disulfonic acid
- Common name: 6-Amino-1,3-naphthalenedisulfonate
- Molecular formula: C10H9NO6S2
- Molecular weight: 303.314 g/mol
- Smiles notation: c12c(cc(S(O)(=O)=O)cc1S(O)(=O)=O)cc(N)cc2
- InChl: 1S/C10H9NO6S2/c11-7-1-2-9-6(3-7)4-8(18(12,13)14)5-10(9)19(15,16)17/h1-5H,11H2,(H,12,13,14)(H,15,16,17)
- Substance type: Organic
- Physical state: Solid - Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Amount / concentration applied:
- 2mg
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 24 hours
- Number of animals:
- No data available
- Details on study design:
- No data available
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- Severe skin irritating effects were observed.
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- The test chemical 6-amino-1,3- Naphthalene disulfonic acid (CAS No: 118-33-2) was severely irritating to rabbits’ skin after 24 hours of exposure.
Hence, 6-amino-1,3- Naphthalene disulfonic acid(CAS No: 118-33-2) can be considered as skin irritant. - Executive summary:
Skin irritation test of test chemical 6-aminonaphthalene-1,3-disulfonic acid (CAS No: 118-33-2) was conducted on rabbit to examine the degree of skin irritancy caused by the chemical.
The rabbits were exposed to 2 mg of chemical dermally for 24 hours and later observed for skin reactions.
Since the chemical induce sever skin reactions,6-amino-1,3- Naphthalene disulfonic acid(CAS No: 118-33-2) was considered to be irritating to rabbits’ skin.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from peer reviewed journals and authoritative databases
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To assess the eye irritation potential of 6-amino-1,3- Naphthalene disulfonic acid in rabbits
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material : 6-aminonaphthalene-1, 3-disulfonic acid
- Molecular formula : C10H9NO6S2
- Molecular weight : 303.314 g/mol
- Smiles notation : c12c(cc(S (=O)=O)cc1S (=O)=O )cc cc2
- Substance type: Organic
- Physical state: Solid - Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- no data available
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 750 µg
- Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- 24 hours
- Duration of post- treatment incubation (in vitro):
- no data available
- Number of animals or in vitro replicates:
- no data available
- Details on study design:
- no data available
- Other effects / acceptance of results:
- no data available
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Reversibility:
- not specified
- Remarks on result:
- probability of severe irritation
- Irritant / corrosive response data:
- severe irritation was observed
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- 6-amino-1,3- Naphthalene disulfonic acid (CAS No: 118-33-2) was severely irritating to rabbit eyes after 24 hours of exposure.
Hence, 6-amino-1,3- Naphthalene disulfonic acid (CAS No: 118-33-2) can be considered to be an eye irritant. - Executive summary:
The eye irritation potential of 6-amino-1,3- Naphthalene disulfonic acid (CAS No: 118-33-2) was assessed in rabbits.
750 µg of 6-amino-1,3- Naphthalene disulfonic acid was instilled into rabbit eyes and observed for signs of irritation till 24 hours.
6-amino-1,3- Naphthalene disulfonic acid was severely irritating to rabbit eyes after 24 hours of exposure.
Hence, 6-amino-1,3- Naphthalene disulfonic acid (CAS No: 118-33-2) can be considered to be an eye irritant.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin irritation:
Various studieshas been investigated for the test chemical6-aminonaphthalene-1,3-disulfonic acid (CAS No: 118-33-2)to observe the potential for dermal irritation to a greater or lesser extent. The studies are based on in vivo experiments in rabbits for target chemical6-aminonaphthalene-1,3-disulfonic acid (CAS No: 118-33-2) and its structurally similar read across substances2-aminonaphthalene-1,5-disulfonic acid (CAS No: 117-62-4)and 7-aminonaphthalene-1,3,6-trisulphonic acid (CAS No: 118-03-6) .The predicted data using the OECD QSAR toolbox andDanish QSAR databasehas also been compared with the experimental data and summarized as below;
Skin irritation study of test chemical 6-aminonaphthalene-1,3-disulfonic acid (CAS No: 118-33-2) was reported by Richard J Lewis, Sr (2012), GREIM H., J. AHLERS, R. BIAS, B. BROECKER, H. HOLLANDER, H.P. GELBKE, H.-J. KLIMISCH, I. MANGELSDORF, A. PAETZ, N SCHGN, G. STROPP, R. VOGEL, C. WEBER, K. ZIEGLER-SKYLAKAKIS and E. BAYER (1994) and RTECS (1997) to examine the degree of skin irritancy caused by the chemical on rabbit. The rabbits were exposed to 2 mg of chemical dermally for 24 hours and later observed for skin reactions. Since the chemical induce sever skin reactions,6-amino-1,3- Naphthalene disulfonic acid(CAS No: 118-33-2) was considered to be irritating to rabbits’ skin.
In a prediction done by SSS (2017) using the OECD QSAR toolbox with log kow as the primary descriptor, the skin irritation potential was estimated for test chemical6-aminonaphthalene-1,3-disulfonic acid (CAS No: 118-33-2).The chemical 6-aminonaphthalene-1,3-disulfonic acid (CAS No: 118-33-2)is estimated to be irritating to skin of rabbits.
According toDanish QSAR database, theskin irritation effects were estimated by using four different models i.e, Battery, Leadscope, SciQSAR and CASE Ultra for Based on estimation, severe skin irritation effects were known when6-aminonaphthalene-1,3-disulfonic acid (CAS No: 118-33-2)was exposed to rabbit skin.
The above results were further supported by the experimental studies carried out by Richard J. Lewis, Sr. (2012)and RTECS (2015) for two structurally similar read across substances 7-aminonaphthalene-1,3,6-trisulphonic acid (CAS No: 118-03-6) and 2-aminonaphthalene-1,5-disulfonic acid (CAS No: 117-62-4) on rabbits’ skin. The rabbits were exposed to both the chemicals (individually) for 24 hrs at 500 mg and observed for signs of irritation. The treated rabbits produced mild irritating effects in both the studies. Thus the chemicals 7-aminonaphthalene-1,3,6-trisulphonic acid (CAS No: 118-03-6) and 2-aminonaphthalene-1,5-disulfonic acid (CAS No: 117-62-4) were considered as irritating to the skin of rabbits.
Thus on the basis of available data for the 6-aminonaphthalene-1,3-disulfonic acid (CAS No: 118-33-2) and its structurally similar read across substances2-aminonaphthalene-1,5-disulfonic acid (CAS No: 117-62-4)and 7-aminonaphthalene-1,3,6-trisulphonic acid (CAS No: 118-03-6) ,it can be concluded thatchemical 6-aminonaphthalene-1,3-disulfonic acid (CAS No: 118-33-2) is able to cause skin irritation and thus considered as irritating.Comparing the above annotations with the criteria of CLP regulation, it can be classified under the category “Category 2 (irritant)”.
Eye irritation:
In different studies,the test chemical6-aminonaphthalene-1,3-disulfonic acid (CAS No: 118-33-2) has been investigated for potential for ocular irritationto a greater or lesser extent. The studies are based on in vivo experiments in rabbits for target chemical6-aminonaphthalene-1,3-disulfonic acid (CAS No: 118-33-2) and its structurally similar read across substances2-aminonaphthalene-1,5-disulfonic acid (CAS No: 117-62-4)and 7-aminonaphthalene-1,3,6-trisulphonic acid (CAS No: 118-03-6) .The predicted data using the OECD QSAR toolbox has also been compared with the experimental data and summarized as below;
The ocular irritation potential of chemical 6-aminonaphthalene-1,3-disulfonic acid (CAS No: 118-33-2) was assessed by Richard J Lewis, Sr (2012), GREIM H., J. AHLERS, R. BIAS, B. BROECKER, H. HOLLANDER, H.P. GELBKE, H.-J. KLIMISCH, I. MANGELSDORF, A. PAETZ, N SCHGN, G. STROPP, R. VOGEL, C. WEBER, K. ZIEGLER-SKYLAKAKIS and E. BAYER (1994)and RTECS (1997) on rabbit. About 750 µg of 6-amino-1,3- Naphthalene disulfonic acid was instilled into rabbit eyes and observed for signs of irritation till 24 hours. 6-amino-1,3- Naphthalene disulfonic acid was severely irritating to rabbit eyes after 24 hours of exposure. Hence, 6-amino-1,3- Naphthalene disulfonic acid (CAS No: 118-33-2) can be considered to be an eye irritant.
In a prediction done by SSS (2017) using the OECD QSAR toolbox with log kow as the primary descriptor, the eye irritation potential was estimated for test chemical6-aminonaphthalene-1,3-disulfonic acid (CAS No: 118-33-2).The chemical 6-aminonaphthalene-1,3-disulfonic acid (CAS No: 118-33-2)is estimated to be irritating to eye of rabbits.
The above results were further supported by the experimental studies carried out by Richard J. Lewis, Sr. (2012)and RTECS (2015) for two structurally similar read across substances 7-aminonaphthalene-1,3,6-trisulphonic acid (CAS No: 118-03-6) and 2-aminonaphthalene-1,5-disulfonic acid (CAS No: 117-62-4) on rabbits’ eye as follows;
In case of 7-Amino-1,3,6-naphthalenetrisulfonic acid (CAS No: 118-03-6), 500 mg of 7-Amino-1,3,6-naphthalenetrisulfonic acid was instilled into rabbit eyes and observed for signs of irritation till 24 hours.
In case of 2-aminonaphthalene-1,5-disulfonic acid (CAS No: 117-62-4),20 mg of 2-aminonaphthalene-1,5-disulfonic acid was instilled into the eyes of rabbits. Then rabbits were observed for signs of ocular lesions after 24 hours.
Both the chemicals caused moderate irritation to the rabbit eyes after 24 hours. Hence the chemicals 7-Amino-1,3,6-naphthalenetrisulfonic acid (CAS No: 118-03-6) and 2-aminonaphthalene-1,5-disulfonic acid (CAS No: 117-62-4) can be considered as moderately irritating to the rabbits’ eye.
Thus on the basis of available data for the 6-aminonaphthalene-1,3-disulfonic acid (CAS No: 118-33-2) and its structurally similar read across substances 2-aminonaphthalene-1,5-disulfonic acid (CAS No: 117-62-4)and 7-aminonaphthalene-1,3,6-trisulphonic acid (CAS No: 118-03-6) ,it can be concluded thatchemical 6-aminonaphthalene-1,3-disulfonic acid (CAS No: 118-33-2) is able to cause ocular lesions and thus considered as irritating.Comparing the above annotations with the criteria of CLP regulation, it can be classified under the category “Category 2 (irritant)”.
Justification for classification or non-classification
The skin and eye irritation potential of test chemical6-aminonaphthalene-1,3-disulfonic acid (CAS No: 118-33-2) and its structurally similar read across substances2-aminonaphthalene-1,5-disulfonic acid (CAS No: 117-62-4)and 7-aminonaphthalene-1,3,6-trisulphonic acid (CAS No: 118-03-6)were observed in various studies. The results obtained from these studies indicate that the chemical-aminonaphthalene-1,3-disulfonic acidis likely to cause skin and eye irritation. Hence-aminonaphthalene-1,3-disulfonic acid (CAS No: 118-33-2)can be classified under the category “Category 2 (irritant)”for skin and eye as per CLP.
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