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EC number: 202-358-5 | CAS number: 94-71-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Based on availble studies, Guetol is:
- very slightly irritating for the skin and not classified for this endpoint.
- severely irritating for the eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Additional information
Skin irritation:
Only one study was available, selected as key study, with reliability 1 according to Klimisch cotetion criteria.
The summary of this study is the following:
In a study (CIT 2003),the potential of the test item Guetol to induce skin irritation was evaluated in rabbits according to OECD 404 guideline.
A single dose of 0.5 mL of the undiluted test item was applied to the closely-clipped skin of one flank.
The test item was held in contact with the skin by means of a semi-occlusive dressing.
Cutaneous reactions were observed approximately 1 hour, 24, 48 and 72 hours after removal of the dressing.
The mean values of the scores for erythema and oedema were calculated for each animal.
After a 4-hour exposure (three animals), a well-defined erythema was noted in 2/3 animals on day1. Avery slight erythema persisted in one of them up to day 3.
Mean scores over 24, 48 and 72 hours for each animal were 0.0, 0.0 and 0.7 for erythema and 0.0, 0.0 and 0.0 for oedema.
Based on these results, the test item Guetol is very slightly irritant when applied topically to rabbits but not warranting classification according to EU GHS (CLP 1272/2008).
Eye irritation:
Only one study was available, selected as key study, with reliability 1 according to Klimisch cotetion criteria.
The summary of this study is the following:
In a study (CIT, 2003), the potential of the test item Guetol to induce ocular irritation was evaluated in one rabbit according to OECD 405 guideline.
A single dose of 0.1 mL of the undiluted test item was instilled into the left conjunctival sac.
The right eye was not treated and served as control.
The eyes were not rinsed after administration of the test item, but were rinsed on days 2 and 3,
for 30 seconds, using sterile isotonic saline solution (0.9% NaCl).
Ocular reactions were observed approximately 1 hour, 24, 48 and 72 hours after the administration and then daily until day 6 (sacrifice).
The mean values of the scores for chemosis, redness of the conjunctiva, iris lesions and corneal opacity were calculated.
Severe conjunctival reactions (severe chemosis, moderate redness of the conjunctiva and whitish purulent discharge) were observed from day1. Aslight iritis and a slight corneal opacity were also noted from day 2.
Therefore, as severe ocular reactions were observed from day 1 and as poor clinical conditions were noted from day 3 up to day 6, the animal was killed on day 6 for ethical reasons.
Mean scores calculated for the animal over 24, 48 and 72 hours were 4.0 for chemosis, 3.0 for redness of the conjunctiva, 1.0 for iris lesions and 2.0 for corneal opacity.
Based on these results, the test item Guetol is considered as severely irritant when administered by ocular route to rabbits, warranting classification asEye irr Cat. 1 "Causes serious eye damages", according to EU GHS (CLP 1272/2008).
Justification for classification or non-classification
Based on available data, and EU classification criteria, guetol is not classified for skin irritation.
Based on severe cunjunctival reactions with absence of reversibility over 6 days post instillation and the fact that animal was killed for ethical reasons, guetol should be classified as "causes serious eye damage" Cat. 1 (H318)), based on EU GHS criteria.
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