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EC number: 433-460-1 | CAS number: 210880-92-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 05 Aug - 07 Aug, 1997
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- 1984
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Niedersächsisches Umweltministerium, delivered on 07 Jul, 1997
- Analytical monitoring:
- yes
- Vehicle:
- no
- Details on test solutions:
- The stock solutions were prepared with dilution water.
The test substance has been dissolved homogeneously at all test concentrations. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- 2 to 24 h old daphnids were used for the range finding and main study. They had been obtained by removing the mother animals twice within 22 h. The daphnids were acclimated to the dilution water 2 hours before exposure.
- Test type:
- static
- Water media type:
- not specified
- Limit test:
- no
- Total exposure duration:
- 48 h
- Nominal and measured concentrations:
- Nominal: 1.0 - 3.2-10 - 32- 100 - 270 mg/L
Measured ranged from 97% to 104% - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 26 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Remarks on result:
- other: recalculated value
- Validity criteria fulfilled:
- yes
- Remarks:
- For further details please refer to “Any other information on results incl. tables”.
- Conclusions:
- The present guideline study was conducted in compliance with GLP. Under the test conditions used, the EC50 48h for Daphnia magna was 26 a.s. mg/L.
Reference
Please refer to "overall remark/ attached background material" field for result tables.
Table 1: Validity criteria for OECD 202 (2004)
Criterion from the guideline |
Outcome |
Validity criterion fulfilled |
In the control, including the control containing the solubilising agent, not more than 10% of the daphnids should have been immobilized. |
0% immobilization at the end |
yes |
The dissolved oxygen concentration at the end of the test should be ≥ 3 mg/L in control and test vessels. |
Lowest value 8.0 mg /L |
yes |
Description of key information
From short-term key study, the 48-hour EC50 for aquatic invertebrates exposed to the present test material was 0.029 mg a.s./L in freshwater.
From short-term supporting study, the 96-hour LC50 for aquatic invertebrates exposed to the present test material was 0.053 mg a.s./L in saltwater.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Remarks:
- This endpoint was re-calculated
- Effect concentration:
- ca. 0.029 mg/L
Marine water invertebrates
Marine water invertebrates
- Dose descriptor:
- LC50
- Remarks:
- supportive study
- Effect concentration:
- 0.053 mg/L
Additional information
Four GLP-studies are available for short-term toxicity testing to aquatic invertebrates and one of them was identified as key study.
In the key study (2000), the acute toxicity of test substance to invertebrates was investigated in a 48-hours static test with Chironomus riparius according to guideline OPPTS 850.1790. Five first instar per replicate and four replicate per concentration were exposed for 48 hours under static conditions to nominal concentrations of 0.007, 0.013, 0.025, 0.050 and 0.10 mg/L, alongside with a control. Based on this study, the EC50 for aquatic invertebrates exposed to test substance in the freshwater was 0.029 mg as/L.
There are four additional studies available, one conducted with Americamysis bahia two with Daphnia magna and one Crassostrea virginica; the resulting EC50 and LC50 were 0.053 mg a.s./L, 26 a.s. mg/L, > 119 mg a.s./L and > 129.14, respectively. These studies were considered suitable for supporting purpose.
In the first supporting study (2000) the acute toxicity of test material to A. bahia was determined in a 96-h flow-through test according to guideline OPPTS 8501035. The 96-hour LC50 of the technical active ingredient was determined to be 0.053 mg a.s./L based on the measured concentrations.
In the second supporting study (2000) the acute toxicity of test material to daphnia was determined in a 48-h-static test according to guideline OECD 202. The 48-hour EC50 of the technical active ingredient was determined to be 26 mg a.s./L based on the nominal concentrations.
In the third supporting study (2000), the acute toxicity of test material to daphnia was determined in a 48-h-static test according to guideline OECD 202.The 48-hour EC50 of the technical active ingredient was determined to be > 119 mg a.s./L based on the mean measured concentrations.
In the fourth supporting study (1999), the acute toxicity of test material to C. virginica was determined in a 96-h flow-through limit test according to US EPA-72.3 guideline.The 96-hour EC50 of the technical active ingredient was determined to be > 129.14 mg a.s./L, based on the mean measured concentration. Based on this study, the EC50 for C. virginica exposed to test substance in the saltwater was > 129.14 mg a.s./L.
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