3-methoxy-N,N-dimethylpropan-1-amine

Toxicity to microorganisms

Administrative data

Endpoint:

toxicity to microorganisms, other

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Remarks:

non-standard information included in biodegradation study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2020

Report date:

2020

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

OECD 301F was applied (see biodegradation study summary for all methodological details), and included a toxicity control where the reference substance sodium benzoate was monitored for biodegradation based on O2 consumption, in presence of 22 mg/L DMMOPA.

GLP compliance:

yes (incl. QA statement)

Test material

Test material information

Constituent 1

Reference substance name:

(3-methoxypropyl)dimethylamine

EC Number:

827-772-9

Cas Number:

20650-07-1

Molecular formula:

C6H15NO

IUPAC Name:

(3-methoxypropyl)dimethylamine

Test organisms

Test organisms (species):

activated sludge, domestic

Details on inoculum:

see biodegradation study summary

Study design

Test type:

static

Limit test:

yes

Total exposure duration:

28 d

Test conditions

Reference substance (positive control):

yes

Remarks:

benzoic acid, sodium salt

Results and discussion

Effect concentrations

Key result

Duration:

28 d

Dose descriptor:

EC50

Effect conc.:

> 22 mg/L

Nominal / measured:

nominal

Conc. based on:

other: test material introduced at t0

Basis for effect:

other: inhibition of biodegradation of sodium benzoate

Details on results:

In the reference control, biodegradation of sodium benzoate reached 84% and 88% within 14 and 28 days of exposure, resp.
In the toxicity control with 22 mg/L DMMOPA, biodegradation of sodium benzoate reached 61% and 67% within 14 and 28 days of exposure, resp.
Therefore, the test substance had no significant inhibitory effect on the activity of the microbial inoculum. The EC50 was above 22 mg/L.

Applicant's summary and conclusion

Validity criteria fulfilled:

not applicable

Remarks:

non-standard method as a complement inside a biodegradation study

Executive summary:

In an OECD 301F study, the reference substance sodium benzoate was readily biodegradable in the toxicity control experiment with 22 mg/L DMMOPA. Therefore, DMMOPA did not have a significant toxic or inhibitory effect on the activity of the microbial inoculum. The corresponding EC50 was > 22 mg/L over 28 days.