3-methoxy-N,N-dimethylpropan-1-amine

Toxicity to aquatic algae and cyanobacteria

Administrative data

Endpoint:

effects on growth of green algae

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2021

Report date:

2021

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 201 (Freshwater Alga and Cyanobacteria, Growth Inhibition Test)

GLP compliance:

yes (incl. QA statement)

Test material

Test material information

Constituent 1

Reference substance name:

(3-methoxypropyl)dimethylamine

EC Number:

827-772-9

Cas Number:

20650-07-1

Molecular formula:

C6H15NO

IUPAC Name:

(3-methoxypropyl)dimethylamine

Sampling and analysis

Analytical monitoring:

yes

Details on sampling:

measured at 0h and 72h

Test solutions

Vehicle:

no

Details on test solutions:

0, 1.0, 3.2, 10, 32 and 100 mg/L (analytically confirmed
nominal concentrations)

Test organisms

Test organisms (species):

Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)

Study design

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

72 h

Test conditions

Test temperature:

21 - 22°C.

pH:

7.5-8.2

Nominal and measured concentrations:

The measured concentrations at the start and at the end of the test were in agreement with the nominal concentrations, i.e. were at 81-107% relative to nominal at both time points.

Reference substance (positive control):

no

Results and discussion

Effect concentrations

Effect concentrations 1

Key result

Duration:

72 h

Dose descriptor:

EC10

Effect conc.:

75 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

growth rate

Effect concentrations 2

Duration:

72 h

Dose descriptor:

NOEC

Effect conc.:

>= 32 - < 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

growth rate

Effect concentrations 3

Key result

Duration:

72 h

Dose descriptor:

EC50

Effect conc.:

> 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

growth rate

Details on results:

achieved concentrations were stable over 72h

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Executive summary:

In a static test, algae ErC50(72h) was >100 mg/L, NOEC(growth rate) was >32 mg/L, and ErC10 was 75 mg/L based on analytically confirmed nominal concentrations.