Registration Dossier
Registration Dossier
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EC number: 827-772-9 | CAS number: 20650-07-1
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 020
- Report date:
- 2020
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: GB/T 29763-2013 Chemicals-Rare Minnow (Gobiocypris rarus) acute toxicity test
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- (3-methoxypropyl)dimethylamine
- EC Number:
- 827-772-9
- Cas Number:
- 20650-07-1
- Molecular formula:
- C6H15NO
- IUPAC Name:
- (3-methoxypropyl)dimethylamine
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
- Details on test solutions:
- 0 (control) 120 mg/L based on a preliminary assay
Test organisms
- Test organisms (species):
- other: Gobiocypris rarus (rare minnow)
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Remarks on exposure duration:
- frequency of renewal was every 24h.
Test conditions
- Test temperature:
- 21.9°C to 22°C
- pH:
- 7.38 to 7.83: test-item dependent increase in pH
- Nominal and measured concentrations:
- During the test, the measured concentrations of the test substance analyzed by HPLC-MS varied less than 20% during each renewal (-3.14% - 4.73%), while all new solutions varied within ±20% of its arithmetic mean measured concentrations (-3.91% - 3.91 %). The biological response results were reported based on time-weighted arithmetic means of the measured concentrations.
- Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 127 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 127 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- no mortality occured
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Executive summary:
In a semi-static limit test in Gobiocypris rarus (freshwater fish), LC50(96h) and NOEC(96h) were both above 127 mg/L based on time-weighted average measured concentrations of DL-2AP.
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