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Diss Factsheets
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EC number: 206-735-5 | CAS number: 371-40-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to soil macroorganisms except arthropods
Administrative data
- Endpoint:
- toxicity to soil macroorganisms except arthropods: short-term
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- publication
- Title:
- METABONOMIC ASSESSMENT OF TOXICITY OF 4-FLUOROANILINE, 3,5-DIFLUOROANILINE AND 2-FLUOR0-4-METHYLANILINE TO THE EARTHWORM EISENIA VENETA (ROSA): IDENTIFICATION OF NEW ENDOGENOUS BIOMARKERS
- Author:
- Jacob G. Bundy
- Year:
- 2 002
- Bibliographic source:
- Environmental Toxicology and Chemistry, Vol 21, No.9, 2002
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 207 (Earthworm, Acute Toxicity Tests)
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-fluoroaniline
- EC Number:
- 206-735-5
- EC Name:
- 4-fluoroaniline
- Cas Number:
- 371-40-4
- Molecular formula:
- C6H6FN
- IUPAC Name:
- 4-fluoroaniline
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Samples were analyzed on a Broker Avance DRX600 spectrometer at a frequency of 600.13 MHz
Test substrate
- Vehicle:
- not specified
- Details on preparation and application of test substrate:
- Fully clitellate adult individuals were selected for bioassay work and allowed to depurate on moist filter paper for 24 h before the start of the test. Medium-weight filter paper was cut to fit inside a glass via! without overlapping. The area of filter paper used was 52 cm2. Tue compound under test was dissolved in hexane and applied to the filter paper to give a nominal concentrationin g/cm2 and the hexane allowed to evaporate. The paper was then moistened with 1 ml of distilled water, a single earthworm added, and the via! sealed. The via! was then incubated in the dark for a period of 72 h.
nitrogen, and stored at 20 C until sample preparation
Test organisms
- Test organisms (species):
- other: Eisenia veneta
- Animal group:
- annelids
- Details on test organisms:
- Earthworms (E. veneta) were taken from a culture maintained
at the Centre for Ecology and Hydrology Monks Wood
(Abbots Ripton, Huntingdon, UK)
Study design
- Study type:
- laboratory study
- Substrate type:
- filter paper
- Total exposure duration:
- 72 h
- Post exposure observation period:
- At the end of the exposure period the earthworm was removed and stored at -20°C until sample preparation
Test conditions
- Reference substance (positive control):
- not specified
Results and discussion
Effect concentrations
- Duration:
- 72 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.115 mg/cm²
- Basis for effect:
- mortality
Applicant's summary and conclusion
- Conclusions:
- The median lethal conenctration value obtained for 4-fluoroaniline is 0.115 mg/cm²
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