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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23 Novembre 2015 to 05 May 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Justification for type of information:
- A discussion and report on the read across strategy is provided as an attachment in Section 13 of the dossier.
- Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- according to guideline
- Guideline:
- other: Procedure was compatible with Method C7 Abiotic Degradation, Hydrolysis as a Function of pH of Commission Regulation (EC) No 440/2008 of 30 May 2008, Method 111 of the OECD Guidelines for Testing of Chemicals, 13 April 2004 and OCSPP Method 835.2120.
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Lot 0900
Purity 98.8% - Analytical monitoring:
- yes
- Details on sampling:
- The sample solutions were taken from the waterbath at various times and the pH of each solution recorded.
- Buffers:
- The test system used sterile buffer solutions at pH’s 4, 7 and 9.
Buffer solution (pH 4): Citric acid 0.006 mol dm-3, Sodium chloride 0.004mol dm-3, Sodium hydroxide 0.007mol dm-3
Buffer solution (pH 7): Disodium hydrogen orthophosphate (anhydrous) 0.003mol dm-3, Potassium dihydrogen orthophosphate 0.002 mol dm-3, Sodium chloride 0.002 mol dm-3
Buffer solution (pH 9):Disodium tetraborate 0.001mol dm-3, Sodium chloride 0.002mol dm-3 - Details on test conditions:
- Testing was undertaken at pH 4, with solutions being maintained at 50.0 ± 0.5 °C, 60.0 ± 0.5 °C and 70.0 ± 0.5 °C for periods of 264, 192 and 144 hours respectively. Testing was also undertaken at pH 7, with solutions being maintained at 50.0 ± 0.5 °C, 60.0 ± 0.5 °C and 70.0 ± 0.5 °C for periods of 504, 432 and 120 hours respectively. Testing was also undertaken at pH 9, with solutions being maintained at 50.0 ± 0.5 °C, 60.0 ± 0.5 °C and 70.0 ± 0.5 °C for periods of 192, 168 and 52 hours respectively.
- Duration:
- 264 h
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 192 h
- pH:
- 4
- Temp.:
- 60 °C
- Duration:
- 144 h
- pH:
- 4
- Temp.:
- 70 °C
- Duration:
- 504 h
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 432 h
- pH:
- 7
- Temp.:
- 60 °C
- Duration:
- 120 h
- pH:
- 7
- Temp.:
- 70 °C
- Duration:
- 192 h
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 168 h
- pH:
- 9
- Temp.:
- 60
- Duration:
- 52 h
- pH:
- 9
- Temp.:
- 70 °C
- Number of replicates:
- 2
- Positive controls:
- no
- Transformation products:
- yes
- No.:
- #1
- No.:
- #2
- Key result
- pH:
- 4
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0 s-1
- DT50:
- 155 d
- Key result
- pH:
- 7
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0 s-1
- DT50:
- 74 d
- Key result
- pH:
- 9
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0 s-1
- DT50:
- 154 d
- Validity criteria fulfilled:
- yes
- Conclusions:
- The estimated rate constants and half-lives at 25°C for the test item were; pH 4: estimated rate constant: 5.19x10-8 s-1 at 25°C, Estimated half life at 25°C: 155 days. pH 7: estimated rate constant: 1.08x10-7 s-1 at 25°C, Estimated half life at 25°C: 74 days. pH 9: estimated rate constant: 5.22x10-8 s-1 at 25°C, Estimated half life at 25°C: 154 days.
- Executive summary:
The testing was conducted according to a procedure which is compatible with Method C7 Abiotic Degradation, Hydrolysis as a Function of pH of Commission Regulation (EC) No 440/2008 of 30 May 2008, Method 111 of the OECD Guidelines for Testing of Chemicals, 13 April 2004 and OCSPP Method 835.2120. The results of the study found that the estimated rate constants and half-lives at 25°C for the test item were; pH 4: estimated rate constant: 5.19x10-8 s-1 at 25°C, Estimated half life at 25°C: 155 days. pH 7: estimated rate constant: 1.08x10-7 s-1 at 25°C, Estimated half life at 25°C: 74 days. pH 9: estimated rate constant: 5.22x10-8 s-1 at 25°C, Estimated half life at 25°C: 154 days.
Reference
Description of key information
The testing was conducted according to a procedure which is compatible with Method C7 Abiotic Degradation, Hydrolysis as a Function of pH of Commission Regulation (EC) No 440/2008 of 30 May 2008, Method 111 of the OECD Guidelines for Testing of Chemicals, 13 April 2004 and OCSPP Method 835.2120. The results of the study found that the estimated rate constants and half-lives at 25°C for the test item were; pH 4: estimated rate constant: 5.19x10-8 s-1 at 25°C, Estimated half life at 25 °C: 155 days. pH 7: estimated rate constant: 1.08x10-7 s-1 at 25°C, Estimated half life at 25 °C: 74 days. pH 9: estimated rate constant: 5.22x10-8 s-1 at 25°C, Estimated half life at 25 °C: 154 days.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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