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EC number: 251-607-4 | CAS number: 33629-47-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
- Objective of study:
- toxicokinetics
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other:
- Version / remarks:
- Japanese Ministry of Agriculture, Foresty and Fisheries (MAFF) Guidelines
- Qualifier:
- according to guideline
- Guideline:
- other: EPA FIFRA GPLS, 40 CRF Part 160
- Principles of method if other than guideline:
- The pharmacokinetics was investigated in Sprague-Dawley CD rats (5 rats/sex/dose group) at two dose levels, 8 mg/kg body weight (low) and 800 mg/kg bw (high). Animals were administered a single dose of [14C]butralin by oral gaage. Prior to treatment, animals were cannulated wia the jugular vein and the cannula used to collect periodic blood samples.
- GLP compliance:
- yes (incl. QA statement)
Test material
- Radiolabelling:
- yes
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
Doses / concentrationsopen allclose all
- Dose / conc.:
- 8 mg/kg bw/day (nominal)
- Dose / conc.:
- 800 mg/kg bw/day (nominal)
- No. of animals per sex per dose / concentration:
- 5
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Following a single oral administration of [14C]-butralin to Sprague Dawley rats at the dose-levels of 8.0 or 800 mg/kg bw, absorption and elimination rates of blood radioactive residues were moderately rapid.
At the low dose-level, females required a longer time to reach Cmax (8 hrs) than males (4 hrs), but the Cmax residue concentrations were similar in both sexes (1.05 and 1.18 ppm respectively in males and females). Therefore, the exposure (AUC) was approximately 2.6 times higher in females than in males (23.7 and 63.5 ppm.hrs respectively in males and females).
At the high dose-level the Cmax was only 50 times higher at the high dose-level than at the low dose-lvel, the AUC were approximately 136 times and 72 times higher (respectively in males and females) at the high dose-level than at the low dose-level.
At the low dose-level the T1/2 was longer in females than in males, indicating a possible difference in the elimination rate of butralin between sexes.
Although the Cmax at the high dose (mean 49.0 ppm versus 1,1 ppm at the low dose) did not increase linearly with dose, the exposure of the animals (AUC, mean 3829 ppm.hrs at the high dose versus 44 ppm at the low dose) did.
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