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EC number: 245-912-1 | CAS number: 23850-94-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 17 May 1979 to 20 June 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The test material was applied once dermally to the prepared sites under gauze patches. The patches were secured with adhesive tape and the trunks were wrapped with impervious material. Dermal reactions were scored at 24 hours, days 3, 7 & 14 by the Draize scoring system. The rabbits were observed daily for 14 days for signs of toxicity, pharmacological effects and mortality.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Butyltris[(2-ethyl-1-oxohexyl)oxy]stannane
- EC Number:
- 245-912-1
- EC Name:
- Butyltris[(2-ethyl-1-oxohexyl)oxy]stannane
- Cas Number:
- 23850-94-4
- Molecular formula:
- C28H54O6Sn
- IUPAC Name:
- butyltris[(2-ethyl-1-oxohexyl)oxy]stannane
- Test material form:
- liquid
- Details on test material:
- - Appearance: clear liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: approximately 9 weeks old
- Weight at study initiation: 2.2 - 2.8 kg
- Housing: The animals were housed 2/cage in suspended wire mesh cages (30 x 18 x 18 ").
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: at least one week
ENVIRONMENTAL CONDITIONS
- Temperature: 20 to 21 °C
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Immediately prior to dosing, the fur was clipped from the abdomen of the animals. The clipped area was 200 cm².
- % coverage: 10% of the body surface
- Type of wrap if used: The test material was applied once dermally to the prepared sites under gauze patches. The patches were secured with adhesive tape and the trunks were wrapped with impervious material.
REMOVAL OF TEST SUBSTANCE
- The test material was kept in contact with the skin for 24 hours, at which time the wrappings were removed. An estimate of the amount of material remaining was recorded.
- The exposure site was wiped, but not washed, to remove excess material.
TEST MATERIAL
- Amount(s) applied: 2.0, 4.0, 8.0 and 16.0 g/kg. - Duration of exposure:
- 24 hours
- Doses:
- 2.0, 4.0, 8.0 and 16.0 g/kg.
- No. of animals per sex per dose:
- - 2.0 and 4.0 g/kg: 2 animals per sex
- 8.0 g/kg: 3 males and 1 female
- 16.0 g/kg: 1 male - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Dermal reactions were scored at 24 hours and on days 3, 7 and 14 according to the Draize scoring system.
- The rabbits were observed daily for 14 days for signs of toxicity, pharmacological effects and mortality.
- Body weights were recorded pre-test and in the survivors at 14 days.
- The rabbits were not examined for gross pathology. - Statistics:
- The LD50, if possible, was calculated according to the method of Litchfield & Wilcoxon.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 8 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- All animals survived the testing.
- Clinical signs:
- other: Isolated instances of lethargy, ptosis, few faeces in pan, and yellow nasal discharge were sporadically noted in 3 animals. Eight out of thirteen animals appeared normal at all times. Lethargy was noted in two animals on day 0, but had cleared by day 1 an
- Gross pathology:
- Not performed.
Any other information on results incl. tables
Table 1: Individual Bodyweights
Dose level (g/kg) |
Animal No. and sex |
Bodyweight (kg) |
|
Day 0 |
Day 14 |
||
2.0 |
1-F |
2.7 |
2.9 |
2-F |
2.5 |
2.7 |
|
3-M |
2.8 |
2.9 |
|
4-M |
2.8 |
3.0 |
|
4.0 |
5-M |
2.2 |
2.5 |
6-M |
2.4 |
2.5 |
|
7-F |
2.5 |
2.5 |
|
8-F |
2.4 |
2.5 |
|
8.0 |
9-M |
2.7 |
2.6 |
10-M |
2.8 |
2.8 |
|
11-F |
2.5 |
2.4 |
|
12-M |
2.5 |
2.7 |
|
16.0 |
13-M |
2.6 |
2.5 |
Table 2: Dermal Scores
Dose level (g/kg) |
Animal No. and sex |
Dermal Scores |
|||||||
Day 0 |
Day 3 |
Day 7 |
Day 14 |
||||||
E |
O |
E |
O |
E |
O |
E |
O |
||
2.0 |
1-F |
2 |
2 |
2 |
2 |
1f |
0 |
0 |
0 |
2-F |
2 |
1 |
2 |
1 |
1f |
1 |
0 |
0 |
|
3-M |
1 |
1 |
1 |
1 |
1f |
0 |
1 |
0 |
|
4-M |
1 |
1 |
2 |
2 |
1 |
1 |
1 |
0 |
|
4.0 |
5-M |
2 |
2 |
2 |
2 |
1f |
2 |
0f |
0 |
6-M |
1 |
2 |
2 |
2 |
1f |
2 |
0f |
0 |
|
7-F |
2 |
2 |
2 |
2 |
1f |
1 |
1f |
0 |
|
8-F |
3 |
1 |
3 |
2 |
2f |
1 |
1f |
0 |
|
8.0 |
9-M |
2 |
2 |
3 |
3 |
4f |
2 |
4fe |
2 |
10-M |
3 |
2 |
3 |
2 |
2 |
2 |
4fe |
2 |
|
11-F |
2 |
2 |
2 |
3 |
3 |
2 |
4fe |
2 |
|
12-M |
3 |
2 |
2 |
2 |
2 |
2 |
4fe |
2 |
|
16.0 |
13-M |
2 |
2 |
2 |
2 |
3f |
2 |
4fe |
2 |
E = erythema
O = oedema
e = slight eschar
f = skin flaking
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified in accordance with EU Criteria
- Conclusions:
- Under the conditions of this study the acute dermal LD50 of the test material was determined to be greater than 8000 mg/kg.
- Executive summary:
The acute dermal toxicity of the test material was determined in a study using New Zealand White rabbits.
During the study, animals were treated with a dose of 2.0, 4.0, 8.0 or 16.0 g/kg of test material under an occlusive patch for 24 hours. The rabbits were observed daily for 14 days for signs of toxicity, pharmacological effects and mortality. Body weights were recorded pre-test and in the survivors on day 14. Dermal reactions were scored at 24 hours and on days 3, 7 and 14 according to the Draize scoring system.
Under the conditions of the study all animals survived. Isolated instances of lethargy, ptosis, few faeces in pan, and yellow nasal discharge were sporadically noted in 3 animals. Eight out of thirteen animals appeared normal at all times. Lethargy was noted in two animals on day 0, but had cleared by day 1 and both animals then remained normal throughout the test. Slight weight loss was noted in the higher dose animals and dermal reactions were moderate to severe at the higher dose levels.
The acute dermal LD50 of the test material was therefore determined to be in excess of 8000 mg/kg.
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