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Diss Factsheets
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EC number: 208-021-9 | CAS number: 505-84-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 13. Aug 1968 - 02. Sep 1968
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 968
- Report date:
- 1968
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- BASF test - Inhalation Risk Test
- GLP compliance:
- no
- Test type:
- other: inhalation risk test
- Limit test:
- yes
Test material
- Reference substance name:
- 1,1'-[methylenebis(oxy)]dibutane
- EC Number:
- 219-909-0
- EC Name:
- 1,1'-[methylenebis(oxy)]dibutane
- Cas Number:
- 2568-90-3
- Molecular formula:
- C9H20O2
- IUPAC Name:
- 1,1'-[methylenebis(oxy)]dibutane
Constituent 1
Test animals
- Species:
- rat
- Sex:
- female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: unchanged (no vehicle)
- Duration of exposure:
- 8 h
- Concentrations:
- 11. 24 mg/L (calculated from substance loss)
(calculated saturated vapor concentration: 6.6 mg/l) - No. of animals per sex per dose:
- 6
- Control animals:
- not specified
- Details on study design:
- Duration of observation period following administration: 7 days
- Frequency of observations: several times on the day of administration, at least once each workday.
- Frequency of weighing: days 0, 7
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LC50
- Effect level:
- > 11.24 mg/L air (nominal)
- Based on:
- not specified
- Exp. duration:
- 8 h
- Remarks on result:
- other: Inhalation Risk Test: Substance concentration was calculated from substance loss during the exposure
- Mortality:
- No mortality occured.
- Clinical signs:
- other: During the exposure escape attempts, irritation of the mucous membranes and intense respiration. At the end of the exposure period high stepping almost staggering gait, tremor of the whole body. 24 h post application piloerection and calm behaviour
- Body weight:
- The animals gained weight (no single recording of weight gain).
- Gross pathology:
- 1x bronchial pneumonia (right) and vicariious emphysema (left); 1x chronic bronchitis and bronchiectasis.
Any other information on results incl. tables
The inhalation of a highly saturated vapor-air-mixture at 20 °C caused no mortality after 8 h of exposure.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No effects were observed in the acute inhalation toxicity studies which warrant classification in accordance with EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation No. 1272/2008.
- Executive summary:
The acute inhalation toxicity studies for Ethylal and Butylal can be used as source data for Propylal. The 4-hr LC50 values for Ethylal and Butylal were estimated to be 4428.7 ppm and 5.62 mg/L, respectively. In order to accurately compare the LC50 values, the values were converted into mg/m³. Notably, for the conversion of ppm to mg/m³ the ideal gas law was used (Annex III). The recalculated LC50 values for Ethylal and Butylal are 19120.38 and 5620 mg/m³, respectively. In terms of bioavailability, Ethylal is considered to be the worst-case, as it has the highest vapour pressure 17000 Pa at 20 °C, compared to a vapour pressure of 111 Pa at 25 °C for Butylal. However, when considering crossing the biological membrane in the lungs, Butylal is expected to be more favourable for absorption in the lungs. Additionally, Butylal has a lower LC50 value and is therefore, the worst-case scenario in this read across. Based on these findings, it is concluded that the target and source substances have similar toxicity potentials via the inhalation route. The read-across is applied with a high level of confidence (AO 5 in accordance with the ECHA RAAF document (2017)).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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