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EC number: 208-021-9 | CAS number: 505-84-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 2011-03-11 to 2011-03-31
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Version / remarks:
- Adopted 13 April 2004
- Deviations:
- yes
- Remarks:
- The amounts of test item was not given as % of applied initial concentration neither as mg/L.
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Dipropoxymethane
- EC Number:
- 208-021-9
- EC Name:
- Dipropoxymethane
- Cas Number:
- 505-84-0
- Molecular formula:
- C7H16O2
- IUPAC Name:
- 1-(propoxymethoxy)propane
- Test material form:
- liquid
Constituent 1
- Radiolabelling:
- no
Study design
- Analytical monitoring:
- yes
- Buffers:
- Buffer of pH 4.0 (Kolthoff and Vleeschhouwer):
Two solutions were prepared:
- 0.1 N sodium hydroxide: 0.4 g of NaOH was dissolved in water and the solution was adjusted to 100 mL with the same solvent (solution n°1).
- 0.1 M monopotassium citrate: 2.302 g of monopotassium citrate were dissolved in water and the solution was adjusted to 100 mL with the same solvent (solution n°2).
In order to obtain a buffer of pH 4.0, 4.5 mL of solution n°1 and 25 mL of solution n°2 were mixed and the final solution was adjusted to 50 mL with water.
Buffer of pH 7.0 (Clark and Lubs):
Two solutions were prepared:
- 0.1 N sodium hydroxide: 0.4 g of NaOH was dissolved in water and the solution was adjusted to 100 mL with the same solvent (solution n°1).
- 0.1 M monopotassium phosphate: 1.36 g of KH2PO4 were dissolved in water and the solution was adjusted to 100 mL with the same solvent (solution n°2).
In order to obtain a buffer of pH 7.0, 14.815 mL of solution n°1 and 25 mL of solution n°2 were mixed and the final solution was adjusted to 50 mL with water.
Buffer of pH 9.0 (Clark and Lubs):
Two solutions were prepared:
- 0.1 N sodium hydroxide: 0.4 g of NaOH was dissolved in water and the solution was adjusted to 100 mL with the same solvent (solution n°1).
- 0.1 M boric acid solution: 0.618 g of boric acid was dissolved in water and the solution was adjusted to 100 mL with the same solvent (solution n°2).
In order to obtain a buffer of pH 9.0, 10.65 mL of solution n°1 and 25 mL of solution n°2 were mixed and the final solution was adjusted to 50 mL with water.
The pH of each prepared buffer solution was checked with a calibrated pH meter. - Details on test conditions:
- The hydrolysis test at the three pH values (4.0, 7.0 and 9.0) was performed at 50 ± 0.5°C for 5 days. Three working solutions at one concentration level of 0.0063 M were prepared in glass tubes as follows: 10 μL of the test item were mixed with 10 mL of pH 4.0 buffer, pH 7.0 buffer and pH 9.0 buffer, respectively.
All suitable measures were taken to avoid oxygen, by bubbling helium for 5 minutes before preparation of the solutions. The working solutions were incubated in the dark.
After incubation, 1 mL of each solution was mixed with 1 mL of ethyl acetate. The mixture was then centrifuged at 3000 rpm for 10 minutes to allow the separation of the two phases. The organic phase was introduced into a vial and injected into the GC system.
- Number of replicates:
- 1
Results and discussion
- Preliminary study:
- The analytical response obtained for a freshly prepared sample at pH 7.0 was compared to those observed after incubation of the different working solutions. As can be seen from the results presented in Table 1, no hydrolysis is observed after 5 days. Consequently, the test item is considered hydrolytically stable and no additional testing is required according to the OECD TG 111
- Test performance:
- Repeatability of the analytical method used to quantify the test item was checked by triplicate analysis of a freshly prepared sample at pH 7.0. The results presented in Table 2 demonstrate the excellent repeatability of the method, since the RSD value is close to 0 %.
The analytical method is also sufficiently sensitive to quantify test item concentrations down to 10 % or less of the initial concentration. Indeed, the limit of detection is 0.010 mM, as determined during the validation of the GC-MS method. - Transformation products:
- not measured
Dissipation DT50 of parent compound
- Remarks on result:
- hydrolytically stable based on preliminary test
Any other information on results incl. tables
Table 1 Results of the hydrolysis of propylal as afunction of pH
Test conditions | Peak area | Difference (%) |
pH 7 / T0 | 8804558 | 0 |
pH 7 / T5 days, 50°C | 8825677 | 0,24 |
pH 4 / T5 days, 50°C | 8777852 | -0,3 |
pH 9 / T5 days, 50°C | 8810647 | 0,07 |
Table 2 Method repeatability
ID GC/MS | Peak area |
LAMBSTAB85 | 8804886 |
LAMBSTAB86 | 8811987 |
LAMBSTAB87 | 8810945 |
Mean: | 8809273 |
Standard deviation: | 3835 |
RDS (%): | 0,04 |
Applicant's summary and conclusion
- Conclusions:
- Propylal is considered hydrolytically stable in aquatic systems at pH values normally found in the environment (pH 4 - 9).
- Executive summary:
The hydrolysis as a function of pH of propylal have been determined using a procedure designed to be compatible with Method 111 of the OECD Guidelines for Testing of Chemicals, 13 April 2004. The half-life of the test item was shown to be greater than 1 year at 25 °C for pH 4, pH 7 and pH 9.
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