Registration Dossier
Registration Dossier
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EC number: 203-704-8 | CAS number: 109-78-4
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Toxicity studies of acetone cyanohydrin and ethylene cyanohydrin.
- Author:
- Sunderman WF, Kincaid JF
- Year:
- 1 953
- Bibliographic source:
- Archives of Industrial Hygiene and Occupational Medicine 8: 371-376
- Reference Type:
- review article or handbook
- Title:
- Cyanides and Nitriles
- Author:
- Hartung R
- Year:
- 1 982
- Bibliographic source:
- In: Clayton GD, Clayton FE (ed.) Patty's Industrial Hygiene and Toxicology. 3 rd ed., Vol. 2C: 4874 - 4878; John Wiley and|Sons, New York ISBN: 0-471-09258-4
Materials and methods
- Principles of method if other than guideline:
- Method: other: no data
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3-hydroxypropiononitrile
- EC Number:
- 203-704-8
- EC Name:
- 3-hydroxypropiononitrile
- Cas Number:
- 109-78-4
- Molecular formula:
- C3H5NO
- IUPAC Name:
- 3-hydroxypropanenitrile
- Reference substance name:
- Ethylene cyanohydrin
- IUPAC Name:
- Ethylene cyanohydrin
- Details on test material:
- IUCLID4 Test substance: no data
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- not specified
Administration / exposure
- Details on exposure:
- Route of Administration: dermal
- Duration of treatment / exposure:
- 17 days
- Frequency of treatment:
- 15 times
Doses / concentrations
- Remarks:
- Doses / Concentrations:
up to 3.8 g
Basis:
- Control animals:
- other: no data specified
- Details on study design:
- Post-exposure period: no data
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
In 15 repeated applications to the rabbit skin, there was no injury.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
