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EC number: 207-889-6 | CAS number: 499-75-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Toxicity to fish
The acute toxicity of Carvacrol was assessed with acute fish toxicity test on Zebrafish (Brachydanio rerio), over an exposure period of 96 hours in a semi-static system. Under the conditions of this study, the observed and calculated endpoints for the effect of CARVACROL were as the following:
The 24h LC50value was foud to be 6.96 mg/L (nominal) (95 % conf. limits: 5.30 - 9.69 mg/L). The 48, 72h and 96h LC50values were all found to be 6.17 mg/L (nominal) (95 % conf. limits: 4.83 - 9.92 mg/L). The 96h LC100value wsa 10.0 mg/L (nominal). The 96h No-Observed Effect Concentration (NOEC) was 1.25 mg/L (nominal) and the 96h Lowest Observed Effect Concentration (LOEC) were 2.5 mg/L (nominal).
Toxicity to aquatic invertebrates
Acute toxicity of CARVACROL on Daphnia magna was assessed in an acute immobilisation test, over an exposure period of 48 hours in a semi-static test system. Under the conditions of this Daphnia magna acute immobilisation study, the observed endpoints for the effect of CARVACROL were the followings:
The 24h and 48h EC50values were calculated to be 8.74 (7.36 -11.79) mg/L (measured) and 6.06 (5.10 -7.28) mg/L (measured). The 48h EC100value was > 8.61 mg/L (measured). The 48h NOEC and LOECwere 2.16 mg/L (measured) and 4.27 mg/L (measured), respectively.
Toxicity to algae
The effect of Carvacrol test item was assessed on algal growth using the unicellular green alga Pseudokirchneriella subcapitata (formerly known as Selenastrum capricornutum), over an exposure period of 72 hours. With respect to the inhibitory effect of the test item, the 0-72 h average specific growth rates were significantly different from that of the control group in the examined concentration range of 2.5-10.0 mg/L (nominal), therefore the NOEC was determined as 1.25 mg/L (nominal) and LOEC was determined as 2.5 mg/L(nominal). The 0-72 h areas and yield were significantly different from that of the control group in the examined concentration range of 1.25-10.0 mg/L (nominal). The NOEC was determined as 0.625 mg/L (nominal); the LOEC was determined as 1.25 mg/L (nominal).
Toxicity to micro-organisms
Activated sludge respiration inhibition test (carbon and ammonium
oxidation) was carried out with CARVACROL to the influence of the test
item on the activity of activated sludge microorganisms by mensuring the
respiration rate under defined condtions. With respect to the inhibitory
effect of the test item on the total respiration rate, the 3-hour EC50
value of CARVACROL was determined to be in the range of 10 mg/L to 100
mg/L (75.75 mg/L was calculated, with 95% confidence limits of 68.15
-84.19 mg/L).
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