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EC number: 821-762-8 | CAS number: 4563-56-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to the analogue justification attached to IUCLID section 13.
- Reason / purpose for cross-reference:
- read-across source
- Parameter:
- % degradation (O2 consumption)
- Value:
- < 5
- Sampling time:
- 5 d
- Remarks on result:
- other: mean of two test concentrations
- Parameter:
- % degradation (O2 consumption)
- Value:
- < 5
- Sampling time:
- 15 d
- Remarks on result:
- other: mean of two test concentrations
- Parameter:
- % degradation (O2 consumption)
- Value:
- < 5
- Sampling time:
- 27 d
- Remarks on result:
- other: mean of two test concentrations
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1992
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.6 (Degradation: Chemical Oxygen Demand)
- Deviations:
- not specified
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Deviations:
- not specified
- GLP compliance:
- no
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- sewage, industrial (adaptation not specified)
- Details on inoculum:
- Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): effluent of a domestic sewage treatment plant located in Hennef, Germany
- Water filtered: yes
- Type and size of filter used, if any: inoculum was filtered through a coarse folded filter and the first 200 mL discarded - Duration of test (contact time):
- 27 d
- Initial conc.:
- 2.49 mg/L
- Based on:
- test mat.
- Initial conc.:
- 3.91 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: filtered sewage
- Test temperature: 20 +/- 1 °C
- pH: not stated
- Continuous darkness: yes
TEST SYSTEM
- Culturing apparatus: 300 mL flasks
- Number of culture flasks/concentration: 2
- Measuring equipment: dissolved oxygen content was determined using the oxygen measuring apparatus Syland Temp-O2-Mat 4002
SAMPLING
- Sampling frequency: day 5, 15 and 27
- Sampling method: oxygen content was measured within the test flasks
CONTROL AND BLANK SYSTEM
- Inoculum blank: the oxygen content of the mineral nutrient solution without inoculum and without test substance as well as without test substance but with inoculum was tested on day 0, 5, 15 and 27
- other: to test the inhibition effect of the test substance to the inoculum, an additional test run was prepared containing 3.91 mg test substance/L and 5.0 mg sodium acetate/L
STATISTICAL METHODS: no statistics were performed - Reference substance:
- acetic acid, sodium salt
- Remarks:
- 5 mg/L and 10 mg/L
- Parameter:
- % degradation (O2 consumption)
- Value:
- < 5
- Sampling time:
- 5 d
- Remarks on result:
- other: mean of 2 test concentrations
- Parameter:
- % degradation (O2 consumption)
- Value:
- < 5
- Sampling time:
- 15 d
- Remarks on result:
- other: mean of 2 test concentrations
- Parameter:
- % degradation (O2 consumption)
- Value:
- < 5
- Sampling time:
- 27 d
- Remarks on result:
- other: mean of two test concentrations
- Details on results:
- The biological oxygen demand was <5% of the chemical oxygen demand in both test concentrations at all sampling dates.
Sodium acetate in the inhibition test (medium contained test substance as well as reference substance) was degraded by 80% at day 27 which indicates that the test concentration did not have inhibitory effects on the inoculum. - Results with reference substance:
- The biodegradation of sodium acetate was >95% .
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- Not readily biodegradable according to the OECD criteria (<5% degradation after 27 d, EU Method C.6).
- Executive summary:
No data are available on the biodegradation in water of Phosphorodithioic acid, O,O-di-dodecyl-esters, zinc salts, neutral and basic (CAS No.4563-56-8). Therefore data from the analogue substance zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (CAS 4259-15-8) were used for read across. This read-across is in accordance with Regulation (EC) No. 1907/2006 Annex XI, 1.5 In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment. This read-across is justified in within the analogue justification in IUCLID Section 13.
A study was performed to assess the biodegradation in water of Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (CAS 4259-15-8) (Rheinchemie, 1992). The method followed was according to the EU Method C.6 and equivalent to the OECD Guidelines for Testing of Chemicals No 301 (1994) under non-GLP. A industrial sewage was used as inoculum. The initial test item concentrations were 2.49 and 3.91 mg/L. The test item was found to be not readily biodegradable under the test conditions at the end of the 27 -day exposure period.The biodegradation of the reference substance (sodium acetat) was >95%.
Referenceopen allclose all
TEST SUBSTANCE
Results of oxygen measurements during the test
|
Decrease in oxygen content of test medium
Biodegradation of test substance
COD: Chemical oxygen demand of test substance (2.26 mg O2/mg) |
REFERENCE SUBSTANCE (SODIUM ACETATE)
Results of oxygen measurements during the test
Decrease in oxygen content of test medium
Biodegradation of reference substance
ThOD: theoretical oxygen demand (0.78 mg O2/mg for sodium acetate |
The test is considered to be valid as validity criteria were fulfilled (more than 60% of the reference substance was degraded after 27 days; the oxygen consumption in the test medium (blank control) did not exceed 0.4 mg/L and was < 0.6 mg/L in the inoculum control after 14 and 27 d).
Description of key information
Not readily biodegradable according to the OECD criteria (<5% degradation after 27 d, EU Method C.6).
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
No data are available on the biodegradation in water of Phosphorodithioic acid, O,O-di-dodecyl-esters, zinc salts, neutral and basic (CAS No.4563-56-8). Therefore data from the analogue substance zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (CAS 4259-15-8) were used for read across. This read-across is in accordance with Regulation (EC) No. 1907/2006 Annex XI, 1.5 In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment. This read-across is justified in within the analogue justification in IUCLID Section 13.
A study was performed to assess the biodegradation in water of Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (CAS 4259-15-8) (Rheinchemie, 1992). The method followed was according to the EU Method C.6 and equivalent to the OECD Guidelines for Testing of Chemicals No 301 (1994) under non-GLP. A industrial sewage was used as inoculum. The initial test item concentrations were 2.49 and 3.91 mg/L. The test item was found to be not readily biodegradable under the test conditions at the end of the 27 -day exposure period.The biodegradation of the reference substance (sodium acetat) was >95%.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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