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Diss Factsheets
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EC number: 210-894-6 | CAS number: 625-45-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
- Principles of method if other than guideline:
- BASF test, study was performed before the implementation of OECD Guidelines.
- GLP compliance:
- no
- Remarks:
- test predated GLP
- Limit test:
- no
Test material
- Reference substance name:
- Methoxyacetic acid
- EC Number:
- 210-894-6
- EC Name:
- Methoxyacetic acid
- Cas Number:
- 625-45-6
- Molecular formula:
- C3H6O3
- IUPAC Name:
- 2-methoxyacetic acid
- Reference substance name:
- 2-methoxyacetic acid
- IUPAC Name:
- 2-methoxyacetic acid
- Details on test material:
- Name of test material:
Methoxyacetic acid
Impurities (identity and concentrations):
appr. 0.2 % formic acid
max. 0.5 % water
max. 0.1 % formaldehyde
< 0.1 % glycolic acid
< 0.1 % oxalic acid
< 0.5 % varied ester
< 0.001 % N
Constituent 1
Constituent 2
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Details on exposure:
- Concentration in vehicle (%): 0.5, 2.0, 7.0, 20.0
Application volume per dose: 10 mL/kg - Doses:
- 50, 200, 700, 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 per sex and dose
- Control animals:
- no
- Details on study design:
- Observation period 14 days
- Statistics:
- On the basis of the observed lethality, the LD50 value was determined.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 50 - < 200
- Remarks on result:
- other: Level of significance: 1 %
Any other information on results incl. tables
Mortality (10 animals, 5 males and 5 females):
50 mg/kg bw: 0/10
200 mg/kg bw: 10/10 (within 7 days)
700 mg/kg bw: 10/10 (within 1 day)
2000 mg/kg bw: 10/10 (within 1 h)
Clinical signs: Dyspnoea, apathy, abnormal position, reeling, atonia, tonic spasms, ruffled fur, cyanosis, paresis.Dissection findings: No treatment-related findings were found in animals died during the study or sacrificed at the end of the observation period.
Applicant's summary and conclusion
- Executive summary:
The following LD50 value has been reported after single intraperitoneal administration: Mouse, i. p. between 50 and 200 mg/kg bw. During the 14-day observation period dyspnoea and apathy were noticed in animals of all dose groups. Gross pathology revealed no treatment-related findings in all animals.
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