Registration Dossier
Registration Dossier
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EC number: 207-321-7 | CAS number: 462-06-6
Specific investigations: other studies
Administrative data
- Endpoint:
- hepatotoxicity
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Centrolobular hepatic necrosis related to covalent binding of metabolites of halogenated aromatic hydrocarbons
- Author:
- Reid, W.D., Krishna, G.
- Year:
- 1 973
- Bibliographic source:
- Exp. Mol. Pathol., 18, 80-99
- Reference Type:
- publication
- Title:
- Biochemical mechanism of hepatic necrosis induced by aromatic hydrocarbons
- Author:
- Reid, W.D., et al.
- Year:
- 1 973
- Bibliographic source:
- Pharmacology, 10, 193-214
- Reference Type:
- publication
- Title:
- Toxicological Evaluations Vol. 13
- Author:
- BG Chemie
- Year:
- 1 998
- Bibliographic source:
- Springer-Verlag Berlin Heidelberg, ISBN 3-540-62658-1
Materials and methods
- Principles of method if other than guideline:
- The hepatotoxic effects of fluorobcnzene and a number of other halogenated benzenes (bromobenzene, iodobenzene, o-dichlorobenzene, p-dichlorobenzene) and the relationship between hepatotoxicity, covalent binding and metabolism were studied in rats after a single intraperitoneal injection.
- GLP compliance:
- no
- Type of method:
- in vivo
Test material
- Reference substance name:
- Fluorobenzene
- EC Number:
- 207-321-7
- EC Name:
- Fluorobenzene
- Cas Number:
- 462-06-6
- Molecular formula:
- C6H5F
- IUPAC Name:
- fluorobenzene
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- intraperitoneal
Results and discussion
- Details on results:
- In contrast to other halogenated benzenes, a single intraperitoneal injection of fluorobenzene did not cause liver necrosis and only occasionally caused necrosis after phenobarbital induction. In parallel with these findings, the tissue concentration and covalent binding to liver proteins were also low in comparison with other halogenated benzenes.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
