Registration Dossier
Registration Dossier
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EC number: 258-416-5 | CAS number: 53179-11-6
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 2015
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
Test material
- Reference substance name:
- Loperamide
- EC Number:
- 258-416-5
- EC Name:
- Loperamide
- Cas Number:
- 53179-11-6
- Molecular formula:
- C29H33ClN2O2
- IUPAC Name:
- 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide
- Details on test material:
- Batch 02742200215
Purity 99.5 %
Expiry date 20/08/2015
Constituent 1
Results and discussion
Water solubility
- Water solubility:
- 10.9 mg/L
- Temp.:
- 20 °C
- pH:
- 6.85 - 6.95
- Remarks on result:
- other: SD of 0.47 mg/l; relative SD of 8.9 %
- Details on results:
- At the plateau, the concentration of Loperamide in water had reached
10.9 +/- 0.5 mg/l at 20.0 +/- 0.5 °C.
= 1.09 +/-0.05 * 10^-2 kg/m^3 (SI units)
(mean value +/- standard deviation of four individual vessels)
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
