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EC number: 260-480-4 | CAS number: 56966-52-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- GLP - Guideline study conducted according to the OECD TG 404 (1981) with following minor deviation: the duration of the observation period depended on the achievement of the reversibility of the skin findings and thus was individual for each animal; the guideline recommends a 14 day period of observation.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- 12.05.1981
- Deviations:
- yes
- Remarks:
- but minor
- GLP compliance:
- yes
Test material
- Reference substance name:
- 5-chloro-2-(2,4-dichlorophenoxy)aniline
- EC Number:
- 260-480-4
- EC Name:
- 5-chloro-2-(2,4-dichlorophenoxy)aniline
- Cas Number:
- 56966-52-0
- Molecular formula:
- C12H8Cl3NO
- IUPAC Name:
- 5-chloro-2-(2,4-dichlorophenoxy)aniline
- Details on test material:
- - Name of test material (as cited in study report): Trichloraminodiphenylether
- Physical state: fluid, brown
- Analytical purity: no data were available to the testing facility at the time the study was conducted
- Impurities (identity and concentrations): no data were available to the testing facility at the time the study was conducted
- Lot/batch No.: 9207 997
- Storage condition of test material: room temperature
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Élevage Cunicole de Val de Selle, 80160 Prouzel
- Weight at study initiation: 2.7 +/- 0.1 kg (mean of 3 males)
- Housing: individually
- Diet (e.g. ad libitum): "Lapins entretien référence 112 C" granules, offered ad libitum
- Water (e.g. ad libitum): tap water filtered through a 0.22 µm filter membrane, offered ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18 +/- 3
- Humidity (%): 50 +/- 20
- Air changes (per hr): non recycled air was filtered
- Photoperiod (hrs dark / hrs light): 12h / 12h
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: The left flank of each animal remained untreated and served for control.
- Amount / concentration applied:
- An amount of 0.5 mL of test material was first melt at ca. 35 °C and was then applied onto a dry hydrophilic gauze (ca. 6 cm²) for application on the skin.
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- The animals were observed during 6, 7 and 14 days, for the first, the second and the third animal respectively.
- Number of animals:
- 3 male animals were used
- Details on study design:
- The gauze with test material was placed onto the shaved skin of the right flank of each animal. The gauze was covered and maintained in place by means of a semiocclusive dressing for 4 hours.
At the end of the treatment period, the dressing was removed and residues of test material were gently wiped away from the application site.
The skin reaction at the application site was evaluated after 1 hour following removal of the dressing, and again after 24, 48 and 72 hours, and then daily until reversibility of the findings was achieved.
The findings were scored as recommended by the OECD TG 404, thus, according to the Draize scoring system (for details, see table below).
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Remarks:
- (mean value)
- Time point:
- other: 24 - 48 - 72 h
- Score:
- 1.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 5 days
- Remarks on result:
- other: no skin dryness was observed
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Remarks:
- (mean value)
- Time point:
- other: 24 - 48 - 72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 6 days
- Remarks on result:
- other: skin dryness was observed on day 5 and 6
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Remarks:
- (mean value)
- Time point:
- other: 24 - 48 - 72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- other: skin dryness was observed from day 5 to day 13
- Irritation parameter:
- edema score
- Basis:
- animal: 1, 2 and 3
- Time point:
- other: 24 - 48- 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- other: edema graded 1 to 2 was seen at reading time point 1 hour
- Irritant / corrosive response data:
- Very slight to clearly defined erythema (scored 1 to 2) was observed in all 3 animals during 5 days; in all 3 cases, erythema at reading time point one hour was accompanied by very slight to slight edema (scored 1 to 2), edema totally disappeared thereafter. From day 6 to 8, full reversibility of erythema was noticed for all 3 animals.
- Other effects:
- Skin dryness at the application site was seen in two animals. In one animal, dryness was observed on days 5 to 6 and disappeared thereafter; in the second animal dryness lasted until day 13 of observation.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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