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EC number: 203-562-7 | CAS number: 108-22-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Isopropenyl acetate is relatively harmless if administered orally,dermally or via inhalation showing LD50 values of > 2000 mg/kg body weight both for the oral and dermal application route and a LC50 of > 22 mg/l for the inhalative route.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 22 000 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
6 female HsdRccHan : WIST rats (Full-Barrier) were administered with a dose of 2000 mg/kg bw according to OECD guideline 423. 0.9% sodium chloride served as a vehicle. It was chosen due to its non-toxic characteristics. After the administration the animals of the first stap showed slight signs of toxicity such as slightly reduced spontaneous reaction, piloerection and arched back. These effects were not seen one day after exposure or later. No treatment related effects on organs or body weight gain were recorded in any of the animals.Under the conditions of the present study it can be stated that the test item Isopropenyl acetate showed slightly acute oral toxic characteristics. The oral LD50 cut-off was determined to be 5000 mg test item /kg body weight due to only slight signs of toxicity. According to GHS (Globally Harmonized Classification System) the test item Isopropenyl acetate was not classified.
For determination of the acute inhalation toxicity (single 4-hour-exposure) of 2-Acetoxypropene (Isopropenyl acetate, Essigsäureisopropenylester) as a vapor, a study in male and female Wistar rats was performed according to OECD-Guideline method 403, as well as EEC and EPA guidelines. No mortality occurred at the analytically determined concentration of 22 mg/l (Limit test). The LC50 for male and female animals (5 animals/group) therefore is > 22 mg/l (> 5300 ppm). Clinical examination revealedeyelid closure, visually accelerated respiration, nasal discharge and crust formation as well as apathy, squatting posture, reduced general state, smeared fur and piloerection . No clinical signs could be detected from post exposure day 7 onward. Body weight development of the male animals was slightly depressed in the first post exposure week but recovered in the second. The female animals did not gain weight throughout the post exposure observation period. During necropsy no macroscopic pathologic findings were noted in the animals examined at the end of the study.
An acute dermal toxicity study of isopropenyl acetate (99.5% pure) was conducted in the Wistar Hsd/Cpb:Wu rat in accordance with OECD Guideline 402 yielded a dermal LD50 of > 2000 mg/kg body weight. Single 24 h semi-occlusive application of 2000 mg isopropenyl acetate/kg bw to the depilated dorsal skin of 5 males and 5 females was tolerated without remarkable findings. During the subsequent 14 days observation period, no animal dies, no skin changes or clinical signs were observed and body weight gain was normal. Terminal necropsy was without abnormal findings.
Justification for classification or non-classification
The studies did not reveal any evidence for classifiing the substance as to the endpoints of acute oral, dermal or inhalative toxicity.
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