Registration Dossier
Registration Dossier
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EC number: 807-157-1 | CAS number: 129677-93-6
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
No effects up to the limit of water solubility.
Key value for chemical safety assessment
Additional information
Since no studies investigating the short-term toxicity of Fatty acids, C8-10, C8-10 alkyl esters (CAS 129677-93-6) to fish are available, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read-across to the structurally related source substances tetradecyl ester (CAS 3234-85-3) and Fatty acids, C8-10, C12-18-alkyl esters (CAS 95912-86-0) was conducted. The source substances are representative to evaluate the short-term toxicity of the target substance to fish. The target substance is characterized as an ester of C8-C10 fatty acid and C8-C10 alcohol. The three source substances are structurally very similar to the target substance. Tetradecanoic acid, tetradecyl ester (CAS 3234-85-3) is a mono-constituent substance consisting of C14 fatty acids esterified with C14 alcohol. Fatty acids, C8-10, C12-18-alkyl esters (CAS 95912-86-0) is a UVCB substance of mainly C8-C10 fatty acid esterified with mainly C12-C14 alcohol. Comparing all substances they only differ slightly in C-chain lengths distribution. None of the selected source substances has a structural alert for an increased toxicity via a specific mode of action. This read-across is justified in detail in the overall summary (IUCLID Section 6.1) and within the analogue justification in IUCLID Section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment.
The first study was performed according to OECD 203 (GLP) and investigated the short-term toxicity of tetradecyl myristate (CAS 3234-85-3) to freshwater fish (Teigeler, 2012).The zebra fish Danio rerio was exposed for 96 h to a limit Water Accommodated Fraction (WAF) concentration of nominal 100 mg/L.GC/EI-MS analysis resulted in a measured initial concentration of 0.189 µg/L which dropped below the detection limit of 0.1 µg/L at the end of exposure after 96 h. No mortality was observed resulting in a LL50 of > 0.189 µg/L (measured initial concentration) and > 100 mg/L (nominal), respectively.
The second study with the read-across substance Fatty acids, C8 - 10, C12 - 18-alkyl esters (CAS 95912-86-0) was performed according to OECD 203 (GLP; Salinas 2013). Danio rerio was exposed to a nominal concentration of 100 mg/L for 96 h (Water Accommodated Fraction). No mortality was observed after 96 h of incubation resulting in a LL50 (96 h) > 100 mg/L (nominal) and a NOELR (96 h) ≥ 100 mg/L (nominal).
Based on the available results from structurally related source substances (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which are characterized by a similar ecotoxicological profile and comparable structure, it can be concluded that Fatty acids, C8-10, C8-10 alkyl esters will not exhibit short-term effects to fish up to the limit of water solubility.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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