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EC number: 410-510-9 | CAS number: 86753-82-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In oral acute toxicity studies an LD50 of > 2000 mg/kg was determined in rats.
Dermal toxicity after single dermal application was tested in male and female rats. The LD50 value for acute dermal toxicity is >2,000 mg/kg bw.
Acute inhalation toxicity: Study was waived
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- according to guideline
- Guideline:
- other: Annex V - method B.1
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- other: Rat (Wistar-derived)
- Vehicle:
- corn oil
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- Male: > 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0Female: > 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
- Clinical signs:
- other: Signs of toxicity related to dose levels:No significant signs of toxicity were observed
- Gross pathology:
- Effects on organs:No macroscopic abnormalities were detected at post mortem
- Interpretation of results:
- not classified
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
- Conclusions:
- The acute oral median lethal dose of the substance was greater than 2000 mg/kg to both male and female rats.
- Executive summary:
A group of 5 male and 5 female rats each received a single oral dose of 2000 mg/kg of the substance. The animals were assessed daily for any signs of systemic toxicity and their bodyweights were recorded at intervals.
No significant signs of toxicity were observed and none of the animals died. the test sample stained yellow the tail, coat and faeces of some of the animals.
The acute oral median lethal dose of the substance was greater than 2000 mg/kg to both male and female rats.
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Species Sprague Dawley rat
Strain HSD: Sprague Dawley SO
Origin HARLAN WINKELMANN Gartenstr. 27, 33178 Borchen SPF breeding colony
Body weight at start of study
male animals mean = 188 g (=100%); s = ± 7.1 g; n = 5
female animals mean = 187 g (= 100 %); s =±7.7g; n = 5
Age at the start of the study 6- 10 weeks
Animal maintenance in fully air-conditioned rooms in macrolon cages (type 4) on soft wood granulate in groups of 5
Room temperature 22 ± 3°C
Relative humidity 50± 20%
Lighting time 12 hours daily
Acclimatization at least seven days
Food ssnif('1 R/M-H (V 1534), ad libitum
Withdrawal of food from about 16 hours before to 3- 4 hours after treatment
Water tap water in plastic bottles, ad libitum
Animal identification fur marking with KMn04 and cage numbering - Route of administration:
- oral: gavage
- Vehicle:
- other: sesame oil
- Details on oral exposure:
- The prepared test substance was administered by gavage to fasted animals at the stated dosage. The observation period following treatment lasted for 14 days.
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- Symptoms were recorded twice every day (in the morning and in the afternoon), on weekends and public holidays only once. During this time the animals were weighed weekly. At the end of the observation period the animals were killed by carbon dioxide asphyxiation, dissected and examined for macroscopically visible changes.
- Preliminary study:
- Comprehensive description of clinical signs:
No symptoms were observed after administration of 2000 mglkg body weight.
Comprehensive description of macroscopic findings:
The animals killed at the end of the observation period showed no macroscopically visible changes. - Key result
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- >= 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths occurred during the whole study.
- Clinical signs:
- other: No symptoms were observed after administration of 2000 mg/kg body weight
- Gross pathology:
- The animals killed at the end of the observation period showed no macroscopically visible changes.
- Other findings:
- none
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- Based on the results obtained in this acute oral toxicity study according to OECD TG 401 the median lethal dose value LD0 of the tets material for male and female rats is greater than 2000 mglkg body weight
- Executive summary:
Acute oral toxicity testing of the test item in Sprague Dawley rats yielded a non-lethal dose (LD0) above 2000 mg/kg body weight in both male and female animals.
After administration of 2000 mg/kg body weight neither deaths nor symptoms occurred.
Development of body weight was not impaired.
All animals were killed at the end of the observation period. They showed no macroscopically visible changes.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- reliable
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- other: Annex V method B.3
- GLP compliance:
- yes
- Limit test:
- yes
- Species:
- other: Rat (Wistar-derived)
- Strain:
- other: APfSD
- Sex:
- male/female
- Type of coverage:
- occlusive
- Vehicle:
- other: Deionised water
- Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- Male: > 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0Female: > 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
- Clinical signs:
- other: There were no significant signs of systemic toxicity
- Gross pathology:
- Effects on organs:There were no treatment related findings at the post mortem examination
- Other findings:
- Signs of toxicity (local):The skin of all animals was stained orange/yellow for 6 days after application which prevented a full assessment of erythema. There was evidence of slight irritation at the application site of the majority of animals for up to 2 days after application
- Interpretation of results:
- not classified
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
- Conclusions:
- The acute dermal median lethal dose was in excess of 2000 mg/kg bw to male and female rats
- Executive summary:
A sample of test substance was assessed for its acute dermal toxicity using a limit version of the B.3 method.
Five male and five female rats each received a single dermal application of 2000 mg/kg of the test sample. The animals were assessed daily for any sighs of systemic toxicity and their bodyweights were recorded at intervals. At the end of the study, all the animals were killed and given a macroscopic post mortem examination.
None of the animals died and there were no significant signs of systemic toxicity. There were no treatment related findings at the post mortem examination.
During the study the test sample stained the application sites orange/yellow for 6 days after application which prevented a full assessment of erythema. However, there was evidence of slight skin irritation (oedema) for up to 2 days after application.
The acute dermal median lethal dose was in excess of 2000 mg/kg bw to male and female rats.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- reliable
Additional information
Acute oral toxicity:
Acute toxicity after single oral application was tested in male and female rats, which received 2000 mg/kg bw (OECD and GLP guideline compliant study). No animals in these studies died. The LD50 value for acute oral toxicity is >2,000 mg/kg bw.
Acute dermal toxicity:
Dermal toxicity after single dermal application was tested in male and female rats, which received 2000 mg/kg bw (B.3 and GLP guideline compliant study). No animals in these studies died. The LD50 value for acute dermal toxicity is >2,000 mg/kg bw.
Acute inhalation toxicity:
Study was waived; substance is not classified for this endpoint. When aerosolized in respirable form, the substance is considered likely to behave like an inert dust.
Justification for classification or non-classification
no classification
In oral acute toxicity studies an LD50 of > 2000 mg/kg was determined in rats.
The LD50 value for acute dermal toxicity is >2,000 mg/kg bw.
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