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Diss Factsheets
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EC number: 455-890-7 | CAS number: 6607-41-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Female rats dosed orally with the substance at 100, 300 and 1000 mg/kg/day were systemically exposed to the substance. Exposure to the substance, in terms of AUClast and Cmax, was similar at all dosage levels on study day 0, but increased as dosage increased from 100 to 1000 mg/kg/day on gestation day 15. Accumulation ratios were 1.2, 1.6, and 3.0 at 100, 300, and 1000 mg/kg/day, respectively.
Key value for chemical safety assessment
Additional information
In an oral reproduction/developmental toxicity screening study systemic exposure to the substance was evaluated in adult female rats, prior to and during gestation. Addititional groups of 8 female rats were administered the test substance at dosage levels of 0, 100, 300, and 1000 mg/kg/day for 14 days prior to pairing through gestation day 15. An additional eight males were assigned to each exposure phase group and were used for breeding purposes only. On study day 0 and gestation day 15, blood samples for determination of plasma drug concentration were collected from females prior to dose administration and at 1, 2, 4, 8, and 24 hours following dose administration. Pregnancy status was determined for each female on gestation day 16.
All female rats dosed orally with the substance were systemically exposed to the substance. Exposure to the substance, in terms of AUClast and Cmax, was similar at all dosage levels on study day 0, but increased as dosage increased from 100 to 1000 mg/kg/day on gestation day 15. On gestation day 15, systemic exposure to the substance increased less than dose-proportionally over the 100 to 1000 mg/kg/day range. Exposure to the substance, in terms of AUClast, was higher on gestation day 15 than on study day 0 at 1000 mg/kg/day, but was similar on both evaluation days at 100 and 300 mg/kg/day. Accumulation ratios were 1.2, 1.6, and 3.0 at 100, 300, and 1000 mg/kg/day, respectively. Peak plasma concentrations were reached at 8, 24, and 8 hours post-dosing on study day 0 and at 8, 4, and 8 hours post-dosing on gestation day 15 at 100, 300, and 1000 mg/kg/day, respectively. Substance concentrations were generally at or near Cmax or fluctuated from 1 through 24 hours post-dosing, except for animals dosed at 100 mg/kg/day on study day 0, where concentrations increased through 8 hours, then decreased through 24 hours post-dosing. Concentration data for the terminal elimination phase was inadequate to determine half-life. Plasma concentrations in control group animals were below the limit of quantitation (BLQ) in all samples collected at all time points on study day 0 and gestation day 15.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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