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Diss Factsheets
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EC number: 930-397-4 | CAS number: 1174918-63-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2000
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study is classified as reliable with restrictions because it is an acceptable, well-documented study report that followed basic scientific principles.
Data source
Reference
- Reference Type:
- publication
- Title:
- Skin absorption of some vaporous solvents in volunteers.
- Author:
- Kezic S, Monster AC, Krüse J, Verberk MM.
- Year:
- 2 000
- Bibliographic source:
- Int Arch Occup Environ Health. 2000 Aug;73(6):415-22.
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Five volunteers were dermally exposed on an area of about 1,000 cm2 (forearm and hand) for 20 or 30 min to hexane vapour.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Hydrocarbons, C5-C7, n-alkanes, isoalkanes, n-hexane rich
- EC Number:
- 930-397-4
- Cas Number:
- 1174918-63-8
- Molecular formula:
- Combination of CnH2n+2 structures and comprised mainly within a carbon number range from C5 to C7.
- IUPAC Name:
- Hydrocarbons, C5-C7, n-alkanes, isoalkanes, n-hexane rich
- Details on test material:
- hexane
Constituent 1
Test animals
- Species:
- human
- Strain:
- not specified
Administration / exposure
- Details on study design:
- The dermal absorption rate for hexane (HEX) in humans was determined. Five volunteers were dermally exposed on an area of about 1,000 cm2 (forearm and hand) for 20 or 30 min. An inhalation exposure with a known dose rate served as a reference. Using the solvent concentrations in exhaled air, measured after both inhalation and dermal exposure, we calculated the maximum absorption rate into the blood, and the average absorption rates into the skin throughout the exposure, using the linear system dynamics method.
Results and discussion
- Signs and symptoms of toxicity:
- not specified
- Dermal irritation:
- not examined
- Absorption in different matrices:
- The absorption rates into the skin, normalised for exposure concentration, was determined to be 0.013 cm/h (HEX). The maximum absorption rate into the blood was determined to be 0.005 nmol/h. A comparison of the estimated whole-body skin uptake with the inhalatory uptake from the same atmosphere, revealed that the dermal uptake contributed 0.1% (HEX) to the total uptake.
Applicant's summary and conclusion
- Conclusions:
- The absorption rates into the skin, normalised for exposure concentration, was determined to be 0.013 cm/h (HEX). The maximum absorption rate into the blood was determined to be 0.005 nmol/h. A comparison of the estimated whole-body skin uptake with the inhalatory uptake from the same atmosphere, revealed that the dermal uptake contributed 0.1% (HEX) to the total uptake.
- Executive summary:
The absorption rates into the skin, normalised for exposure concentration, was determined to be 0.013 cm/h (HEX). The maximum absorption rate into the blood was determined to be 0.005 nmol/h. A comparison of the estimated whole-body skin uptake with the inhalatory uptake from the same atmosphere, revealed that the dermal uptake contributed 0.1% (HEX) to the total uptake.
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