Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 206-059-0 | CAS number: 298-14-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to soil macroorganisms except arthropods: short-term
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Justification for type of information:
- 1. HYPOTHESIS FOR THE ANALOGUE APPROACH
This read-across hypothesis is based on transformation of the target and source substances to common compounds (scenario 1 of the Read-Across Assessment Framework (RAAF), ECHA, March 2017 - transformation to common compounds). The target substance potassium hydrogencarbonate as well as the source substance potassium chloride dissociate in aqueous media to potassium and the respective anion.
For further details, please refer to the Justification for Read-Across attached in Iuclid Chapter 13.
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
Please refer to the Justification for Read-Across attached in Iuclid Chapter 13.
3. ANALOGUE APPROACH JUSTIFICATION
Please refer to the Justification for Read-Across attached in Iuclid Chapter 13.
4. DATA MATRIX
Please refer to the Justification for Read-Across attached in Iuclid Chapter 13. - Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 207 (Earthworm, Acute Toxicity Tests)
- Analytical monitoring:
- no
- Vehicle:
- not specified
- Details on preparation and application of test substrate:
- - Method of mixing into soil (if used): Soil was placed in 1L- Mason-type glass jars. The test substance was first dissolved in water or acetonitrile at a defined concentration before being spiked into the soil. The acetonitrile was evaporated overnight in a chemical hood, and then the soil was rehydrated to 75% of its water holdung capacity /WHC) before the beginning ofthe experiment. WHC measurements were done in triplicate and achieved by adding 15 mL of water to approximately 10g of soil in a Whatman No. 1 filter paper-lined funnel placed onto an Erlenmeyer flask and allowing the ewater to drain out. To avoid evaporation the glassware and the soil were covered with a sheet of aluminium foil. Then, a small quantity of wet soil, approximately 10 g, was taken and dried for 24 hours at 103 ± 2°C.
- Controls: yes
- Chemical name of vehicle (organic solvent, emulsifier or dispersant): acetonitrile, not clear if vehicle was used for KCl
- Concentration of vehicle in test medium (stock solution and final test solution): not reported
- Evaporation of vehicle before use: yes - Test organisms (species):
- Eisenia sp.
- Animal group:
- annelids
- Details on test organisms:
- TEST ORGANISM
- Common name: Earthworm (Eisenia andrei)
- Source: Carolina Supply Co. (Burlington, NC); laboratory culture
- Age at test initiation (mean and range, SD): Adult: animals had a well-developed clitellum
- Weight at test initiation (mean and range, SD): 300 - 600 mg wet weight
ACCLIMATION
- Acclimation period:yes
- Acclimation conditions (same as test or not): yes - Study type:
- laboratory study
- Substrate type:
- other: Two soils were used: artificial OECD soil
- Total exposure duration:
- 14 d
- Post exposure observation period:
- no
- Test temperature:
- 20 ± 1°C
- pH:
- artificial OECD soil: 6.0 ± 0.5
- Moisture:
- artificial OECD soil: 70 - 80% humidity
- Nominal and measured concentrations:
- 0, 3260, 4238, 5869, 7825, 10433 mg/kg dry soil
- Duration:
- 14 d
- Dose descriptor:
- LC50
- Effect conc.:
- 5 595 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: CV (95%): 5338.4 - 5863.9 mg/kg soil dw
- Duration:
- 7 d
- Dose descriptor:
- LC50
- Effect conc.:
- 5 725.1 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: CV (95%): 5455.5 - 6008.1 mg/kg soil dw
- Dose descriptor:
- NOEC
- Effect conc.:
- 4 238 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Dose descriptor:
- LOEC
- Effect conc.:
- 5 869 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Details on results:
- - Mortality at end of exposure period: see table 1
- Total mass of adults at beginning of test: not reported
- Changes in body weigth of live adults (% of initial weight) at end of exposure period: see table 1
- Morphological abnormalities: not reported
- Behavioural abnormalities: not reported
- Other biological observations:no
The CV (chronic value, geometric mean of NOEC and LOEC) was determined for 4987.3 mg/kg soil dw. - Reported statistics and error estimates:
- The toxicity endpoints LC50, NOEC, LOEC and CV were calculated using the ToxCalc program (Version 5.0; Tidepool Scientific Software, McKinleyville, CA). Statistical methods for point estimates included Maximum Likelihood Regression (Finney, 1971 a,b), Spearman -Karber methods (Hamilton et al., 1971 a,b) , the linear interpolation of bootstrapping (Norberg-King, 1993), and the nonlinear interpolation with bootstrapping (US EPA, 1989b). Other statistical methods for LOEC/NOEC included a parametric hypothesis test (e.g. Dunnett's Multiple Comparison Test, Williams Multiple Comparison test) and nonparametric hypothesis test (e.g. Steel's Many-One Rank tests, Wilcoxon's, Two-Sample Test).
- Validity criteria fulfilled:
- not specified
- Conclusions:
- In a 14 d acute toxicity study with earthworms (Eisenia andrei) the LC 50 of KCl in artificial OECD soil was determined to be 5595 mg/kg soil dw (CV (95%): 5338.4 - 5863.9 mg/kg soil dw). The NOEC was 4238 mg/kg soil dw, the LOEC was 5869 mg/kg soil dw.
This result indicates very low toxicity of Potassium to earthworm.
Reference
Table 1: Acute Effects of KCl-Spiked OECD Artificial soil on Eisenia andrei
Nominal concentration (mg/kg dry soil) |
pH (initial/final) |
Mortality (%) after 7 days |
Mortality (%) after 14 days |
Weight changes after 14 days (mg)a) |
Weight changes after 14 days % (w/w)b) |
0 |
6.87/6.90 |
0 |
0 |
-22 ± 14 |
4.3 ± 2.5 |
3260 |
6.72/6.33 |
0 |
0 |
-28 ± 28 |
5.4 ± 5.0 |
4238 |
6.79/6.41 |
0 |
0 |
-55 ± 37 |
10.6 ± 6.9 |
5869 |
6.82/6.71 |
55* |
62.5* |
-136 ± 43 |
27.5 ± 8.3 |
7825 |
6.71/6.91 |
100* |
100* |
NA |
NA |
10433 |
6.69/6.66 |
100* |
100* |
NA |
NA |
*Significant mortality compared to controls
NA: not applicable
a)based on wet matter
b)compared to initial mean weight
Description of key information
Potassium hydrogencarbonate is not expected to have an intrinsic toxic activity to soil macro-organisms except arthropods.
Key value for chemical safety assessment
Additional information
In accordance with REACH Annex 9.4.1, column 2, and Annex X, 9.4.4. short and long-term toxicity testing on invertebrates is only required, if the chemical safety assessment according to Annex I indicates the need to investigate further the effects on terrestric organisms. Potassium and carbonate are essential for almost all living organisms including terrestrial invertebrates and natural components in their habitats. Therefore, potassium hydrogencarbonate is not expected to have a intrinsic toxic activity to terrestrial organisms.
These results are underlined by the test of the read across substance potassium chloride, that indicates very low toxicity of potassium to earthworms (Eisenia andrei). In a 14 d acute toxicity study with earthworms (Eisenia andrei) the LC50 of KCl in artificial OECD soil was determined to be 5595 mg/kg soil dw (CV (95%): 5338.4 - 5863.9 mg/kg soil dw). The NOEC was 4238 mg/kg soil dw, the LOEC was 5869 mg/kg soil dw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.