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Diss Factsheets
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EC number: 203-931-2 | CAS number: 112-05-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1961
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1976
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Principles of method if other than guideline:
- acute dermal toxicity test
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- not stated
- Doses:
- maximum dose: 5 g/kg bw, other doses not stated
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of this study the LD50 was > 5 g/kg bw.
- Executive summary:
The dermal LD50 in rabbits was > 5 g/kg bw (no further details stated; Opdyke, 1978).
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1976
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
- Principles of method if other than guideline:
- Human maximisation test
- GLP compliance:
- not specified
- Type of population:
- general
- Controls:
- no data
- Route of administration:
- dermal
- Conclusions:
- Data reported in the secondary source are insufficient for assessment.
- Executive summary:
A human maximisation test was performed using 25 volunteers. The test item (purity not stated) was applied at a concentration of 12% in petrolatum. After induction (5 times patch application for 48 h) and challenge (14 days after induction, once for 48 h) exposures the summary stated that the test item produced no sensitisation reactions (Opdyke, 1978).
Reading |
1st reading |
Hours after challenge |
72 |
Group |
test group |
Dose level |
12% in petrolatum |
No. with + reactions |
|
Total no. in group |
25 |
Clinical observations |
no sensitisation occured |
Reading |
2nd reading |
Hours after challenge |
96 |
Group |
test group |
Dose level |
12% in petrolatum |
No. with + reactions |
|
Total no. in group |
25 |
Clinical observations |
no sensitisation occured |
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
- Principles of method if other than guideline:
- acute parenteral toxicity test
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Nonanoic acid
- EC Number:
- 203-931-2
- EC Name:
- Nonanoic acid
- Cas Number:
- 112-05-0
- Molecular formula:
- C9H18O2
- IUPAC Name:
- nonanoic acid
- Details on test material:
- - Name of test material (as cited in study report): Pelargonic acid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intravenous
- Vehicle:
- other: 2-% emulsion based on cottonseed oil, emulsifier and buffer
- Doses:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 244 mg/kg bw
- Remarks on result:
- other: i.v. application
Any other information on results incl. tables
The animals exhibited convulsions and collapse followed by respiratory arrest within 2 min.
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of this study the i.v. LD50 in mice was 244 mg/kg bw.
- Executive summary:
The i.v. LD50 in mice was 244 mg/kg bw. The animals exhibited convulsions and collapse followed by respiratory arrest within 2 minutes (Opdyke, 1978).
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