Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 692-061-0 | CAS number: 1207435-39-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Remarks:
- other: 7-day oral dose range-finding
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 01.01.2003 - 30.06.2005
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Remarks:
- Guideline study, final study report not available. Results published in BIOTOX project (BIOTOX. 2005. An assessment of bio-oil toxicity for safe handling and transportation. Final Technical Report. Part I: Publishable Final Report. Report drafted by Blin, J. Project N°: S07.16365. Project co-ordinator: Centre de Coopération Internationale de Recherche Agronomique pour le Développement (Cirad). Partners: Aston University, Bundesforschungsanstalt für Forst- und Holzwirtschaft (BFH)).
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 005
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 407 (Repeated Dose 28-Day Oral Toxicity Study in Rodents)
- Deviations:
- yes
- Remarks:
- range finding study for 28-day study
- Qualifier:
- according to guideline
- Guideline:
- other: EEC Directive No 96/54, B7
- Deviations:
- yes
- Remarks:
- range finding study
- GLP compliance:
- yes
Test material
- Reference substance name:
- Fast Pyrolysis Bio-oil (BIOTOX-21)
- IUPAC Name:
- Fast Pyrolysis Bio-oil (BIOTOX-21)
- Test material form:
- liquid: viscous
- Details on test material:
- BIOTOX-21: Biomass: Spruce, produced with Fluidised bed at 500 °C
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- propylene glycol
- Duration of treatment / exposure:
- 7 days
- Frequency of treatment:
- Daily for 7 days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Basis:
no data
- No. of animals per sex per dose:
- 3
- Control animals:
- yes, concurrent vehicle
Examinations
- Observations and examinations performed and frequency:
- Clinical signs and mortality were checked daily. Body weight was recorded three times and food consumption twice during the dosing period.
- Sacrifice and pathology:
- On completion of the treatment period, after at least 14 hours fasting, all animals were sacrified by carbon dioxide inhalation and exsanguination. The adrenals, brain, heart, testes and epididymes, kidneys, liver, lungs, ovaries, spleen and thymus were weighed wet.
- Other examinations:
- A complete macroscopic post-mortem examination (external surfaces, all orifices, the cranial cavity, the external surfaces of brain, the thoracic, abdominal and pelvic cavities with associated organs and tissues, neck with associated organs and tissues) was performed on all study animals.
- Statistics:
- The specific sequence was used for the statistical analyses of body weight, food consumption and organ weight data.
Results and discussion
Results of examinations
- Details on results:
- No macroscopic abnormalities were observed.
Effect levels
open allclose all
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- >= 150 mg/kg bw/day (actual dose received)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: At 150 mg/kg/day, there were no clinical signs of toxicity, a slight and temporary reduction in the body weight gain of the females and no effect on food consumption.
- Key result
- Dose descriptor:
- dose level:
- Effect level:
- >= 500 mg/kg bw/day (actual dose received)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: At 500 mg/kg/day, there were no clinical signs, but there was a reduction in body weight gain and for males, a reduction in food consumption. One male had dilatation of the duodenum.
- Key result
- Dose descriptor:
- dose level:
- Effect level:
- >= 1 500 mg/kg bw/day (actual dose received)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: see 'Remark'
Target system / organ toxicity
- Key result
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Oral NOAEL was determined as 150 mg/kg/day.
- Executive summary:
The potential toxicity of the test item was evaluated following daily oral administration (gavage) to rats for 7 days. The study was conducted according to OECD 407 guideline and was a dose range-finding study for 28 -day study. No hematological, clinical chemistry or histopathology examinations were carried out. According to study results, NOAEL is 150 mg/kg/day.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.