Bottom residues resulting from the synthesis of propene by propane dehydrogenation

Endpoint summary

Description of key information

Based on the overall available information, the substance is irritating to the skin and the eyes.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion

Endpoint conclusion:

adverse effect observed (irritating)

Eye irritation

Endpoint conclusion

Endpoint conclusion:

adverse effect observed (irritating)

Respiratory irritation

Endpoint conclusion

Endpoint conclusion:

no study available

Additional information

There is no data for CAS # 102242 -57 -9 available but for the single components which can be used for read across:

Skin irritation

Benzene (ca. 50 % in CAS # 102242 -57 -9):

The irritation potential of benzene was assessed on the skins of six shaved rabbits exposed to neat benzene for 4 hours, using an exposure chamber of 6 cm²(Jacobs. 1991). One hour after exposure oedema grade 2 and erythema grade 1 were documented. No oedema, but mean scores of 2.0/2.2/2.4 for erythema were recorded at 24, 48, and 72 hours after the end of exposure. Erythema increased to a mean of grade 3 at 6 days. A second study (Wolf et al, 1956) examined skin irritation potential of benzene following repeated applications. Undiluted benzene was applied 10 -20 times over 2-4 weeks to the ear and shaved abdomen of white rabbits (abdomen bandaged). Perceptible to definite erythema, oedema and superficial necrosis were documented. These effects resulted in a "chapped" appearance and exfoliation of large patches of skin. Although the design and reporting are not compliant with regulatory guidelines the results are consistent with benzene being irritating to rabbit skin.

Methylcyclohexane (ca: 7 % in the substance):

Based on data presented on the ECHA website, this substance is irritating to the skin (CLP: Cat. 2, DSD-DPD: R38)

Cyclopentene (also used as read across for 1 -methylcyclopentene) (both together ca. 17 % in the substance):

Based on the available data for cyclopentene, this substance is irritating to the skin (CLP: Cat. 2, DSD-DPD: R38).

Toluene (ca. 3 % in the substance):

Based on the data on the ECHA website, the substance is irritating to the skin (CLP: Cat. 2, DSD-DPD: R38).

Cyclohexane (ca. 3% in the substance):

Based on the data on the ECHA website, the substance is irritating to the skin (CLP: Cat. 2, DSD-DPD: R38).

Overall weight of evidence: Based on the data for the majority of the single components, the substance is irritating to the skin.

Eye irritation

Benzene (ca. 50 % in the substance):

The key study is considered to be Wolf et al (1956). Instillation of benzene into the rabbit eye caused moderate conjunctival irritation and very slight, transient corneal injury.

Methylcyclohexane (ca. 7 % in the substance):

Based on data presented on the ECHA website, this substance is not irritating to the eye.

Cyclopentene (also used as read across for 1 -methylcyclopentene) (both together ca. 17 % in the substance):

Based on the available data, an eye irritation has to be assumed but the data does not allow an interpretation whether classification as eye irritant is warranted.

Toluene (ca. 3 % in the substance):

Based on the data on the ECHA website, the substance is not irritating to the eye.

Cyclohexane (ca. 3 % in the substance):

Based on the data on the ECHA website, the substance is not irritating to the eye.

Overall weight of evidence: Based on the data for the majority of the single components, the substance is irritating to the eye.

Effects on skin irritation/corrosion: irritating

Effects on eye irritation: irritating

Justification for classification or non-classification

Based on the overall available information, the substance is irritating to the skin and the eyes. (Skin and Eye Cat. 2 according to CLP and R36/38 according to DSD-DPD).