Registration Dossier
Registration Dossier
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EC number: 239-888-1 | CAS number: 15790-07-5 This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 15985:1.
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- other: Predicted data
- Title:
- R: QSAR Toolbox 2.3.0.1132 prediction for LC50 read across evaluation for 15790-07-5
- Author:
- Sustainability Support Services (Europe) AB
- Year:
- 2 013
- Bibliographic source:
- QSAR Toolbox version 2.3
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Estimated data
- Principles of method if other than guideline:
- Acute Rodent Inhalation Toxicity Test
- GLP compliance:
- no
- Test type:
- other: Acute Rodent Inhalation Toxicity Test
Test material
- Reference substance name:
- Aluminium, 6-hydroxy-5-[(4-sulfophenyl)azo]-2-naphthalenesulfonic acid complex
- EC Number:
- 239-888-1
- EC Name:
- Aluminium, 6-hydroxy-5-[(4-sulfophenyl)azo]-2-naphthalenesulfonic acid complex
- Cas Number:
- 15790-07-5
- Molecular formula:
- C16H9AlN2O7S2
- IUPAC Name:
- aluminium(3+) 6-sulfonato-1-[(1E)-2-(4-sulfonatophenyl)diazen-1-yl]naphthalen-2-olate
- Details on test material:
- - Name of test material (as cited in study report): aluminium, 6-hydroxy-5-[(4-sulfophenyl)azo]-2-naphthalenesulfonic acid complex
- Substance type: Organic
- Physical state: Solid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: Carworth Farms-Nelson
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- other: Inhalation: Gas
- Vehicle:
- not specified
- Duration of exposure:
- 4 h
- No. of animals per sex per dose:
- 5-6 mice per group; 10-12 animals
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 1 705.881 other: mg/L
- Based on:
- test mat.
- Exp. duration:
- 4 h
Any other information on results incl. tables
The prediction was based on dataset comprised from the following descriptors: LC50
Estimation method: Taking average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
((("a" and ("b" and ( not "c") ) ) and "d" ) and ("e" and "f" ) )
Domain logical expression index: "a"
Referential boundary: The target chemical should be classified as High (Class III) by Toxic hazard classification by Cramer (original)
Domain logical expression index: "b"
Referential boundary: The target chemical should be classified as Not possible to classify according to these rules by Protein Binding Potency
Domain logical expression index: "c"
Referential boundary: The target chemical should be classified as Halogenated hydrocarbons (SN2) OR Non-reactive (GSH) by Protein Binding Potency
Domain logical expression index: "d"
Referential boundary: The target chemical should be classified as Reactive unspecified by Acute aquatic toxicity MOA by OASIS
Domain logical expression index: "e"
Parametric boundary:The target chemical should have a value of log Kow which is >= 0.515
Domain logical expression index: "f"
Parametric boundary:The target chemical should have a value of log Kow which is <= 1.15
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The 4hr.acute inhalation median lethal concentration (LC50) of aluminium, 6-hydroxy-5-[(4-sulfophenyl)azo]-2-naphthalenesulfonic acid complex in Carworth Farms-Nelson male mouse was found to be 1705.881mg/l. Acute inhalation toxicity of aluminium, 6-hydroxy-5-[(4-sulfophenyl)azo]-2-naphthalenesulfonic acid complex to mouse by inhalative route indicates that the substance does not exhibits acute toxicity by the inhalation route.
- Executive summary:
The 4hr.acute inhalation median lethal concentration (LC50) of aluminium, 6-hydroxy-5-[(4-sulfophenyl)azo]-2-naphthalenesulfonic acid complex in Carworth Farms-Nelson male mouse was found to be 1705.881mg/l. Acute inhalation toxicity of aluminium, 6-hydroxy-5-[(4-sulfophenyl)azo]-2-naphthalenesulfonic acid complex to mouse by inhalative route indicates that the substance does not exhibits acute toxicity by the inhalation route.
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