Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 246-680-4 | CAS number: 25155-30-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
- Acute oral toxicity: The LD50 value of 650 mg/kg in rats were determined for LAS (LAS had a nominal chain length of 12 carbon atoms (range C9-C15) and an average molecular weight of 346)). This show that Sodium dodecylbenzenesulfonate is of a slightly order of acute oral toxicity.
-Acute Dermal Toxicity: An LD50 value of > 2000 mg/kg was obtained. The acute lethal dermal dose was found to be greater than 2000 mg/kg.
The clipped skin on the backs of five male and five female rats were exposed to the test material under an occlusive dressing for 24 hours and observed for another 14 days. Results indicate slight erythema and slight oedema but no acute mortality. The dermal LD50 is > 2000 mg/kg.
This show that Sodium dodecylbenzenesulfonate (the result was read across from LAS) is not toxic for acute Dermal toxicity .
-Acute inhalation toxicity :
Based on the study of Kinney, L. 1985, exposure of 6 male rats to Sodium dodecylbenzenesulfonate the LC50 was 310 mg/m3 (particulate). At 310 mg/m3 one rat died during exposure and two rats died one day post exposure. No mortality occurred at concentrations up to 260 mg/m3.(NOEC).
Results indicate that Sodium dodecylbenzenesulfonate is not toxic for acute inhalation toxicity.
It is concluded that the substance Sodium dodecylbenzenesulfonate meet the criteria to be classified for human health hazards for acute oral effects.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- other: published data
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- according to guideline
- Guideline:
- other: Hagan, EC (1959). Acute toxicity. In: Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics. pp. 17-25. Assoc. of Food and Drug Officials of the US, Bureau of Food and Drugs, Texas State Dept. of Health, Austin, Texas.
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- no
- Species:
- rat
- Strain:
- other: FDRL strain(Wistar-derived)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- young adult rats : FDRL strain (Wistar-derived)They were fasted overnight before this test.
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- 10% and 40 % dispersions of the samles were prepared in distilled water and administered intragastrically.
- Doses:
- 10% and 40% dispersion of LAS sample at dosages of 0.6 and 1.58 g/kg.
- No. of animals per sex per dose:
- 3
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observations for behaviour, appearance and survival were made daily; weighings were performed on days 0, 7, and 14
- Necropsy of survivors performed: yes - Statistics:
- LD50 calculated by the method of Miller, LC, and Tainter, ML. (1994). Estimation of the ED50 and its error by means of logarithmic-probit graph paper. Proc. Soc. Exptl. Biol. Med. 57, 261-264.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 650 mg/kg bw
- Based on:
- act. ingr.
- 95% CL:
- > 587 - < 713
- Mortality:
- Motaliity was not affected.
- Clinical signs:
- other: A high incidence of diarrhea was noted with the use of the higher concentration. Those rats which succumbed appeared to be weak and showed reduced voluntary activity prior to death.
- Gross pathology:
- No significant gross abnormalities were seen at autopsy.
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Acute oral LD50of LAS is 650 +/- 63 mg/kg (with a slope factor of 0.173) when the samples are administered in water dispersion to rats.
The acute oral LD50 in male/female rats is 650mg/kg bw. No significant gross abnormalities were seen at autopsy. - Executive summary:
An acute oral toxicity study was performed for linear alkylbenzene sulphonate (LAS: nominal chain lengh of 12 carbon atoms and an average molecular weight of 346) using rats (FDRL strain, 3/sex/dose) for 14 days. 10% and 40% dispersions of the LAS were prepared in distilled water and administered intragastrically. The animals were observed several times daily for behavior, appearance, and survival for a 14-day period. They were weighed initially and at 7 and 14 days. All animals that died on test as well as those sacrificed at the conclusion of the observation period were necropsied. The acute oral LD50 in rats is 650mg/kg bw.No significant gross abnormalities were seen at autopsy.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 650 mg/kg bw
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Groups of six male 8-week old rats were restrained in perforated, stainless steel cylinders with conical nose pieces. Exposure was nose-only to an aerosol atmosphere for 4 hours. After exposure, rats were returned to their cages and observed for clinical signs for 14 days. Mean measured concentrations in the test chambers were 65, 120, 260, and 310 mg/m3. Chamber temperature ranged between 25-26oC.
- GLP compliance:
- not specified
- Test type:
- other: Approximate lethal concentration (ALC)
- Limit test:
- no
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Spague-Dawley,
- Age at study initiation: 8-week old
- Housing: stainless steel cylinders with conical nose pieces.
- Acclimation period: approximately one week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 25 to 26
- Humidity (%): 40 to 70
- Photoperiod (hrs dark / hrs light): 12/12 - Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose only
- Vehicle:
- other: Exposure was nose-only to an aerosol atmosphere for 4 hours.
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
-Exposure was nose-only to an aerosol atmosphere for 4 hours.
- After exposure, rats were returned to their cages and observed for clinical signs or 14 days.
-Mean measured concentrations in the test chambers were 65, 120, 260, and 310 mg/m3.
-Chamber temperature ranged between 25-26oC.
TEST ATMOSPHERE
-Animals were given high exposures to respirable-sized particles (MMAD at 310 mg/m3 = 2.5 microns).
-Spray products containing LAS are designed to produce large particle sizes. - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- ca. 4 h
- Concentrations:
- 65, 120, 260, and 310 mg/m3.
- No. of animals per sex per dose:
- 6 male 8-week old rats
- Control animals:
- yes
- Details on study design:
- -Groups of six male 8-week old rats were restrained in perforated, stainless steel cylinders with conical nose pieces.
-Exposure was nose-only to an aerosol atmosphere for 4 hours.
-After exposure, rats were returned to their cages and observed for clinical signs for 14 days.
-Mean measured concentrations in the test chambers were 65, 120, 260, and 310 mg/m3.
-Chamber temperature ranged between 25-26oC.
-Animals were given high exposures to respirable-sized particles (MMAD at 310 mg/m3 = 2.5 microns).
-Spray products containing LAS are designed to produce large particle sizes.
-These large particles are needed for efficient delivery of the spray to the surface being cleaned. - Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 310 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: Approximate lethal concentration (ALC).The ALC is defined as the lowest atmospheric concentration generated that caused death in 1 or more rats either on the day of exposure or within 14 days post exposure.
- Sex:
- male
- Dose descriptor:
- other: NOEC
- Effect level:
- 260 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: Based on No mortality occurred at concentrations up to 260 mg/m3.
- Mortality:
- At 310 mg/m3, one rat died during exposure and 2 rats died one day post exposure.
No mortality occurred at concentrations up to 260 mg/m3. - Clinical signs:
- other: Particle sizes are much larger than the respirable particle sizes used in testing and therefore would not be able to reach far into the lungs where effects could occur.
- Body weight:
- During the recovery period, rats exhibited dose dependent weight loss 1 day post exposure followed by normal weight gains.
- Gross pathology:
- none
- Interpretation of results:
- other: not classified
- Remarks:
- Particle sizes are much larger than the respirable particle sizes used in testing and therefore would not be able to reach far into the lungs where effects could occur. Criteria used for interpretation of results: EU
- Conclusions:
- Based on this study, exposure of 6 male rats to Sodium dodecylbenzenesulfonate the LC50 was 310 mg/m3 (particulate). At 310 mg/m3 one rat died during exposure and two rats died one day post exposure. No mortality occurred at concentrations up to 260 mg/m3.(NOEC). Therefore, the health effects of Sodium dodecylbenzenesulfonate need to be considered in the assessment of Dodecylbenzenesulfonic acid.
This results in particle sizes that are much larger than the respirable particle sizes used in testing and, therefore, would not be able to reach far into the lungs where effects could occur. Given this lack of relevance to real-world exposure potential, the use of this study for risk assessment purposes is limited.
Given this lack of relevance to real-world exposure potential, the use of this acute inhalation study for risk assessment purposes is limited. Due to the irritant nature of LAS, it is expected that high LAS aerosol concentrations may be irritating to the upper respiratory tract. - Executive summary:
Based on this study, exposure of 6 male rats to Sodium dodecylbenzenesulfonate the LC50 was310 mg/m3(particulate).At 310 mg/m3 one rat died during exposure and two rats died one day post exposure. No mortality occurred at concentrations up to 260 mg/m3.(NOEC).Therefore, the health effects of Sodium dodecylbenzenesulfonate need to be considered in the assessment of Dodecylbenzenesulfonic acid.
However, it is important to note that this laboratory exposure is not representative of the possible LAS exposure during actual use. In this study, animals were given high exposures to respirable-sized particles (MMAD at 310 mg/m3 = 2.5 microns). Spray products containing LAS are designed to produce large particle sizes. These large particles are needed for efficient delivery of the spray to the surfaces being cleaned. This results in particle sizes that are much larger than the respirable particle sizes used in testing and therefore would not be able to reach far into the lungs where effects would occur. Given this lack of relevance to real-world exposure potential, this use of this study beyond establishing the relative toxicity of the chemical is limited.
Reference
The ALC is defined as the lowest atmospheric concentration generated that caused death in one or more rates either on the day of exposure or within 14 days post exposure. No mortality occurred at concentrations up to 260 mg/m3. At 310 mg/m3 one rat died during exposure and two rats died one day post exposure. The test material is considered moderately toxic by inhalation. However, it is important to note that this laboratory exposure is not representative of the possible LAS exposure during actual use. In this study, animals were given high exposures to respirable-sized particles (MMAD at 310 mg/m3 = 2.5 microns). Spray products containing LAS are designed to produce large particle sizes. These large particles are needed for efficient delivery of the spray to the surfaces being cleaned. This results in particle sizes that are much larger than the respirable particle sizes used in testing and therefore would not be able to reach far into the lungs where effects would occur. Given this lack of relevance to real-world exposure potential, this use of this study beyond establishing the relative toxicity of the chemical is limited.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 310 mg/m³ air
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- other: published data
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- other: CFY (remote Sprague Dawley origin)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Rats were in a weight range of 210 to 239 g prior to dosing on day 1 and approximately six to eight weeks of age. All the rats were acclimated to the experimental environment for a period of 15 days prior to study initiation. Animals were housed in individual metal cages with wire mesh floors. Standard diet and water were provided ad libitum. Each animal was identified by cage number and ear punching.
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Test material was a yellow viscous liquid and was applied to an area clipped with electric clippers (approximately 10% of the area) on the backs of 10 rats (five male, five female) at a dose of 2000 mg/kg. The areas were covered with gauze held in place with an impermeable plastic dressing. At the end of 24 hours the dressings were carefully removed and the treated area of skin washed in warm water and blotted dry with absorbent paper.
- Duration of exposure:
- 24 hr
- Doses:
- 2000 mg/kg (undiluted)
- No. of animals per sex per dose:
- 5 male and 5 female
- Control animals:
- not specified
- Details on study design:
- Animals were observed soon after dosing and then at frequent intervals for the remainder of day 1. On subsequent days the animals were observed once in the morning and again at the end of the experimental day. The treated areas were examined daily for signs of dermal irritation and assessed according to the standard scoring system for erythema, eschar and oedema. All animals were observed for 14 days after dosing. On day 15 all animals were sacrificed and given a macroscopic post-mortem examination of internal organs.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- act. ingr.
- Remarks on result:
- other: undiluted
- Mortality:
- No mortality was observed exposure to 2000 mg/kg of the undiluted test material.
- Clinical signs:
- other: There were no signs of systemic reaction. Well defined or slight erythema and slight oedema were observed at all test sites after removal of the occlusive dressings. These reactions were unresolved before progressive hardening of the skin was first detect
- Gross pathology:
- All terminal autopsy findings were normal.
- Interpretation of results:
- other: not classified
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The acute lethal dermal dose was found to be greater than 2000 mg/kg.
- Executive summary:
The clipped skin on the backs of five male and five female rats were exposed to the test material under an occlusive dressing for 24 hours and observed for another 14 days. Results indicate slight erythema and slight oedema but no acute mortality. The dermal LD50 is > 2000 mg/kg.
Reference
There were no deaths or signs of a systemic reaction following a single dermal application at 2000 mg/kg bw. Well defined or slight erythema and slight oedema were observed at all test sites after removal of the occlusive dressing on Day 2. All test sites were entirely covered by scab formation from Day 7. Sloughing from the scabbed skin began at various timesbetween Day 7 and Day 12 and was completed before termination. Lowbodyweight gains or loss of body weight were recorded for one male andthree females in Day 8. Two of the same females and a third female alsoshowed low bodyweight gain between Days 8 and 15.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Oral toxicity
-An acute oral toxicity study (Oser and Morgareidge, 1965) was performed for linear alkylbenzene sulphonate (LAS: nominal chain lengh of 12 carbon atoms and an average molecular weight of 346) using rats (FDRL strain, 3/sex/dose) for 14 days.10% and 40% dispersions of the LAS were prepared in distilled water and administered intragastrically. The animals were observed several times daily for behavior, appearance, and survival for a 14-day period. They were weighed initially and at 7 and 14 days. All animals that died on test as well as those sacrificed at the conclusion of the observation period were necropsied.
The acute oral LD50in rats is 650 mg/kg bw. No significant gross abnormalities were seen at autopsy.
-An acute oral toxicity study (Hoechst AG, 1988) was performed for Sodium dodecylbenzenesulfonate.The acute oral LD50 in male/female rats is 500-2000 mg/kg bw. No significant gross abnormalities were seen at autopsy.
-An acute oral toxicity study(Hempstock, C1988) was performed for Benzene sulfonic acid, C10-16-alkyl derivatives (68584-22-5) as a surrogateforSodium dodecylbenzenesulfonate.The acute oral LD50 in male/female rats is 775 mg/kg bw. LD50 value is geometric mean between 300 and 2000 mg/kg.
-An acute oral toxicity study (Murmann, P.1984) was performed for Benzenesulfonic acid, C10-13-alkyl derivs., sodium salts as a surrogate for Sodium dodecylbenzenesulfonate.The acute oral LD50 is 1080 mg/kg.
The acute oralLD50 in male/female rats is 650mg/kg bw.This show that Sodium dodecylbenzenesulfonate is of a slightly order of acute oral toxicity.
Dermal toxicity
An LD50 value of > 2000 mg/kg was obtained.The acute lethal dermal dose was found to be greater than 2000 mg/kg.
The clipped skin on the backs of five male and five female rats were exposed to the test material under an occlusive dressing for 24 hours and observed for another 14 days. Results indicate slight erythema and slight oedema but no acute mortality. The dermal LD50 is > 2000 mg/kg.
This show that Sodium dodecylbenzenesulfonate (the result was read across from LAS) is not toxic for acute Dermal toxicity .
Inhalation toxicity
Based on the study of Kinney, L. 1985, exposure of 6 male rats to Sodium dodecylbenzenesulfonate the LC50 was 310 mg/m3 (particulate). At 310 mg/m3 one rat died during exposure and two rats died one day post exposure. No mortality occurred atconcentrations up to 260 mg/m3.(NOEC).
Results indicate that Sodium dodecylbenzenesulfonate is not toxic for acute inhalation toxicity .
It is concluded that the substance Sodium dodecylbenzenesulfonate meet the criteria to be classified for human health hazards for acute oral effects.
Justification for classification or non-classification
Based on the hazard assessment of Sodium dodecylbenzenesulfonate in section 2.1 and 2.2. in IUCLID 5.4., available data for the substance and following the “Guidance on Information Requirement and Chemical Safety Assessment R.8. Characterisation of dose [concentration]- response for human health”, according to the EU’s list of dangerous substances (OJEC No L200/130.7.99)and according to the criteria described in Directive 67/548 and in the CLP Regulation:
Directive 67/548 |
Very Toxic (T+) R28: Very toxic if swallowed R27: Very toxic in contact with skin R26: Very toxic by inhalation R39/26 R39/27 R39/28: Dangerous of very serious irreversible effects Toxic (T): R25: Toxic if swallowed R24: Toxic in contact with skin R23: Toxic by inhalation R39/23 R39/24 R39/25: Danger of very serious irreversible effects Harmful (Xn): R22: Harmful if swallowed R21: Harmful in contact with skin R20: Harmful by inhalation R65: Harmful may cause lung damage if swallowed R21/22 Harmful; Harmful in contact with skin and if swallowed. R68/20 R68/21 R68/22: Possible risk of irreversible effects Other toxicological properties R67: Vapours may cause drowsiness and dizziness |
CLP |
H300 Acute Tox. 2 Fatal if swallowed H310 Acute Tox. 1 Fatal in contact with skin H330 Acute Tox. 2 Fatal if inhaled H370 STOT SE 1 H301 Acute Tox. 3 Toxic if swallowed H311 Acute Tox. 3 Toxic in contact with skin H331 Acute Tox. 3 Toxic if inhaled H370 STOT SE 1 H302 Acute Tox. 4 Harmful if swallowed H312 Acute Tox. 4 Harmful in contact with skin H332 Acute Tox. 4 Harmful if inhaled H304 Asp. Tox. 1 H371 STOT SE 2 (May cause damage to organs (or state all organsaffected if known) (state route of exposure if it is conclusively proventhat no other routes of exposure cause the hazard) Other toxicological properties H336 STOT SE 3 May cause drowsiness or dizziness
|
It is concluded that the substance Sodium dodecylbenzenesulfonate meet the criteria to be classified for human health hazards for acute oral effects:
R22: Harmful if swallowed
H302 Acute Tox. 4 Harmful if swallowed
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.