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Diss Factsheets
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EC number: 228-391-5 | CAS number: 6258-06-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Data on the genotoxicity of the test substance is available only as secondary source (ECB-IUCLID, 2000, Val. 4):
In Vitro
In an Ames assay, the S. typhimurium strains TA 1535, TA1537, TA 98 and TA100 were treated with the test substance. The test was conducted with and without metabolic activation. On S. typhimurium TA 100 and TA 98 a biologically relevant increase in the mutant count compared to the corresponding negative control was found. The positive response was found only with S9 mix. No further details were given (Bayer 17879, 1989).
In another Ames assay S. typhimurium strains TA 1535, TA1537, TA 1538, TA 98 and TA100 were treated with the test substance. The test was conducted with and without metabolic activation and revealed a negative result. No further details were given (Brown and Brown 1979).
An UDS assay was conducted in primary rat liver cells that revealed a negatve result. No further details were given (Bayer 20388, 1991).
In Vivo
In a micronucleus assay, which was conducted under GLP conditions, mice were treated once intraperitoneally with the test substance at concentrations of 20, 175, 350 and 700 mg/kw bw (Bayer 20898, 1991). No relevant indications of a clastogenic effect were found up to and including 700 mg/kg. No further details were given.
Short description of key information:
In vitro:
- Ames: positive in 2 of 4 tested strains with metabolic activation (TA98 and TA100; Bayer 17879, 1989).
- Ames: negative (Brown and Brown 1979)
- UDS: negative (Bayer 20388, 1991)
In vivo:
- Micronucleus assay: negative (Bayer 20898, 1991)
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Dangerous Substance Directive (67/548/EEC)
Based on the available data of the test substance, classification for genetic toxicity under Directive 67/548/EEC is not warrented.
Classification, Labeling, and Packaging Regulation (EC) No. 1272/2008
Based on the available data of the test substance, classification for genetic toxicity under Regulation (EC) No. 1272/2008 is not warrented.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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