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EC number: 231-912-9 | CAS number: 7778-74-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
No data are available
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 30 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
- Quality of whole database:
- A high quality, modern GLP- and guideline-compliant 2-generation study performed with the read-across substance ammonium perchlorate is available.
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
A two-generation reproductive toxicity study (York et al, 2001) was performed to examine the effects of ammonium perchlorate on the male and female reproductive systems in rats, and on the growth and development of offspring. Adult Sprague-Dawley rats (30/sex/group) were given continuous access to ammonium perchlorate in their drinking water at doses of 0, 0.3, 3.0, and 30.0 mg/kg bw/d. F1 generation rats were given the same ammonium perchlorate doses as the P1 generation beginning at weaning and continuing through to the day of sacrifice. Standard reproductive parameters were evaluated; additionally blood was collected for determination of serum thyroid-stimulating hormone (TSH), triiodothyronine (T3), and thyroxine (T4) levels. Histopathological examinations were conducted on major tissues, including the thyroid. No significant changes in developmental parameters were observed. In the F1 generation adult rats, relative thyroid weights were significantly increased in all dose groups for female rats and in the 3.0 and 30.0 mg/kg bw/d dose groups for male rats. Histopathological changes in the thyroid consisted of hypertrophy and hyperplasia that increased in incidence and severity in a dose-related manner. Dose-related, statistically significant changes in TSH and T4 or T3 occurred at doses higher than those that resulted in changes in thyroid weight and thyroid histopathology, 30 mg/kg bw/d. It is concluded that perchlorate is not a reproductive toxicant in rats when administered in the drinking water at doses up to 30 mg/kg bw/d, but it can affect the thyroid at dose levels of ≥3 mg/kg bw/d. Based on these findings, 0.3 mg/kg bw/d is identified by the authors as the NOAEL for this study.
Short description of key information:
A high quality, modern GLP- and guideline-compliant oral (drinking water) 2-generation study performed in the rat with the read-across substance ammonium perchlorate is available.
Justification for selection of Effect on fertility via oral route:
High quality, modern GLP- and guideline-compliant study performed with a read-across substance
Effects on developmental toxicity
Description of key information
High quality, modern GLP- and guideline-compliant developmental toxicity studies performed in the rat and rabbit with the read-across substance ammonium perchlorate using oral (drinking water) are available; studies are supported by other non-standard investigations.
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 1 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rabbit
- Quality of whole database:
- High quality, modern GLP- and guideline-compliant developmental toxicity studies performed in the rat and rabbit with the read-across substance ammonium perchlorate are available; studies are supported by other non-standard investigations.
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Additional information
A developmental toxicity study with ammonium perchlorate in Sprague-Dawley rats (York et al, 2003) identified delays in foetal skeletal ossification only at the highest dose level of 30 mg/kg bw/d. Foetal findings were associated with maternal toxicity (increased thyroid weights). Reduced foeatl thyroid colloid was observed at 1 and 30 mg/kg bw/d; maternal TSH was increased and T4 was decreased in all treated groups; T3 was reduced only at 30.0 mg/kg bw/d. Foetal TSH was increased at 1.0 and 30.0 mg/kg bw/d, T4 was reduced at 30.0 mg/kg bw/d and T3 was decreased in all treated groups. The maternal NOAEL was 1.0 mg/kg bw/d based on increased absolute and relative maternal thyroid weights and histopathology findings. The developmental NOAEL was 1.0 mg/kg bw/d, based on delayed ossification occurred at 30 mg/kg bw/d. The colloid depletion in the thyroids and increased TSH and decreased T3 and T4 levels at lower exposures were considered by the authors to be adaptive and not adverse. No adverse effects on development were observed at dose levels that did not cause maternal toxicity.
A developmental toxicity study with ammoniun perchlorate in the rabbit (York et al, 2001) did not identifiy any effects on uterine or litter parameters. The maternal thyroid was identified as the target organ for ammonium perchlorate; increased incidences of thyroid follicular hypertrophy were observed in does treated with≥10 mg/kg bw/d and significantly decreased T4 was observed in does treated with ≥30 mg/kg bw/d. A maternal NOAEL of 1.0 mg/kg bw/d was derived; in the absence of any effects, the developmental NOAEL was found to be 100 mg/kg bw/d.
Lampe et al (1697) identified effects of potassium perchlorate on the maternal and foetal thyroid in rabbits administered potassium perchlorate in the diet at a single dose level of 100 mg/kg bw/d. Brown-Grant & Sherwood (1971) demonstrated that the oral (drinking water) administration of 1% potassium perchlorate had no significant effect on the blastocyst survival or the ability to implant following the removal of the litter; Brown-Grant (1966) also showed a lack of effect on gestation in the rat.
Justification for selection of Effect on developmental toxicity: via oral route:
High quality, modern GLP- and guideline-compliant study performed with a read-across substance; study reports the lowest NOAEL
Justification for classification or non-classification
The available data do not indicate any specific reproductive of developmental toxicity of potassium perchlorate or the read-across substance ammonium perchlorate. No classification for reproductive toxicity is therefore proposed according to CLP.
Additional information
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