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EC number: 814-433-5 | CAS number: 926622-96-0
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
With high probability acutely not harmful to fish.
Key value for chemical safety assessment
Additional information
QSAR-disclaimer
In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met. Furthermore, according to Article 25 of the same Regulation testing on vertebrate animals shall be undertaken only as a last resort.
According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.
For the assessment of M3ETB (CAS 926622-96-0) (Q)SAR results were used for toxicity to fish. The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment.
Therefore, and for reasons of animal welfare,further experimental studies on toxicity to fish are not provided.
Assessment
Experimental data on the toxicity of M3ETB (CAS 926622-96-0) to fish are not available. Regarding the tonnage band (1 -10 t/a, non-intermediate) a study on the short-term toxicity to fish is not required under REACH.
However, in order to assess the short-term toxicity of the substance to fish, (Q)SAR models were used. The calculated LC50 values are listed for the individual models in the table below; the substance is within the applicability domain of all applied models.
Model |
96-h LC50 (mg/L) |
In AD |
Remarks |
VEGA v1.1.3 Fish Acute (LC50) Toxicity classification (SarPy/IRFMN) 1.0.2 |
>100* |
Yes |
The substance is classified as NON-TOXIC |
US EPA T.E.S.T. (v4.2.1): Predicted Fathead minnow LC50 (96 hr) |
272 |
Yes |
Based on the mean absolute errors of the models the confidence in the predicted results is high. |
ECOlogical Structure-Activity Relationship Model (ECOSAR) Class Program v1.11; EPISuite v4.11 |
471 |
Yes |
- |
OASIS QSAR Toolbox v4.1 |
597 |
yes |
Prediction based on experimental data for several fish species |
* The lowest value available is selected as worst-case data for the chemical safety assessment
Based on a weight-of-evidence approach by the available estimation data, M3ETB (CAS 926622-96-0) is assessed to be with high probability acutely not harmful to fish.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
