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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
07 March 2016 to 30 June 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Key result
Water solubility:
< 0.001 other: gC/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
5.8
Details on results:
The preliminary estimate of water solubility at 20.0 ± 0.5 °C was determined to be less than 6.16E-3 g/L by LC-MS. The solution had a pH of 5.8.

The concentration (g/L) of four test item components in the sample solutions at 20.0 ± 0.5 °C are shown in the following table (table 2):

Table 1: Total mean peak areas for standard and sample solutions

Solution

Mean Total Peak Area

Standard 0.101 mg/L

2.804E+04

* Standard 0.504 mg/L

9.423E+05

Standard 1.01 mg/L

1.783E+06

Standard 2.01 mg/L

2.062E+06

Standard 3.02 mg/L

3.122E+06

Standard 4.03 mg/L

4.062E+06

Standard 5.04 mg/L

5.139E+06

Blank

None detected

Sample 1A

2.428E+06

Sample 1B

2.351+E06

Sample 2A

9.742E+05

Sample 2B

5.489E+05

Sample 3A

4.163E+06

Sample 3B

4.055E+06

* Not used in calibration

 

Table 2:The concentration (g/L) of four test item components in the sample solutions at 20.0 ± 0.5 °C

Sample

Time shaken at ~30 °C

(hours)

Time Equilibrated at 20 °C

(hours)

Concentration

(g/L)

Solution pH

LC-MS

TOC

1

24

24

4.61E-03

6.02E-04

5.7

2

48

24

1.47E-03

5.25E-04

5.6

3

72

24

7.93E-03

5.28E-04

5.7
Conclusions:
The water solubility of the test item was determined to be < 1E-3 gC/L at 20.0 ± 0.5 °C, according to EU Method A.6 and OECD Method 105.
Executive summary:

The water solubility of the test item was determined to be < 1E-03 gC/L at 20.0 ± 0.5 °C, according to EU Method A.6 and OECD Method 105.

Description of key information

The water solubility of the test item was determined to be < 1.0E-03 gC/L at 20.0 ± 0.5 °C, according to EU Method A.6 and OECD Method 105.

Key value for chemical safety assessment

Additional information