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EC number: 247-501-2 | CAS number: 26175-68-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: well performed OECD study conducted in accordance with "Good Scientific Practice"
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- not specified
- GLP compliance:
- no
- Remarks:
- but in accordance with the principles of "Good Scientific Practice"
Test material
- Reference substance name:
- 4-amino-2,5-dichloro-N,N-dimethylbenzenesulphonamide
- EC Number:
- 247-501-2
- EC Name:
- 4-amino-2,5-dichloro-N,N-dimethylbenzenesulphonamide
- Cas Number:
- 26175-68-8
- Molecular formula:
- C8H10Cl2N2O2S
- IUPAC Name:
- 4-amino-2,5-dichloro-N,N-dimethylbenzene-1-sulfonamide
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Poecilia reticulata
- Details on test organisms:
- Breeding: Parental and young fish population was held in two 250 l glass aquaria
Test vessel: 1 l glass aquariuq
Test medium: Tap water from Zürci non aerated
Number of fish: 7 fish per test concentration
Fish length: 1 - 3 cm
Light: 14 hour photoperiod a day supplied by overhead white fluorescent tubes
Temperatute: 22+-1 °C
Feed: Sera micropan; Sera vipan (Sera apanristic GmbH, D-5138 Heidelberg)
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- 1.61 - 1.72 mmol/L (total hardness)
- Test temperature:
- 20.9 - 22.2 °C
- pH:
- 7.6 - 8.3
- Dissolved oxygen:
- 7.0 - 8.3 mg/l
- Nominal and measured concentrations:
- Nominal: 1.52, 2.74, 4.94, 8.88, 16.0 mg/l
- Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- other: cumulative mortality 1/7
- Effect conc.:
- 1.52 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- other: cumulative mortality 0/7
- Effect conc.:
- 2.74 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- other: cumulative mortality 0/7
- Effect conc.:
- 4.94 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- other: cumulative mortality 1/7
- Effect conc.:
- 8.88 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- other: cumulative mortality 6/7
- Effect conc.:
- 16 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The LC50 was determined as 13.4 mg/l
- Executive summary:
The acute lethal toxicity of ADCSF to Poecilia reticulata (Guppy) was investigated under static exposure conditions over a period of 96 hours. The nominal concentrations were 1.52, 2.74, 4.94, 8.88 and 16.0 mg/l. Mortality was observed after 96 hours (cumulated) at 16.0 mg/l (6/7), 8.88 mg/l (1/7) and 1.52 mg/l (1/7).
Based on the data the LC50 was calculated to be 13.4 mg/l
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