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EC number: 232-458-4 | CAS number: 8046-19-3 Extractives and their physically modified derivatives. It is a product which may contain resin acids and their esters, terpenes, and oxidation or polymerization products of these terpenes. (Liquidambar styraciflua, Hamamelidaceae).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
4 HMT tests are available according to Kligman, A. M. (1966) method: One study showed a sensitising effect in 3 out of 27 volunteers after testing with 8% Stryrax ABS. RESIN (Epstein, 1976). In the 3 remaining HMT studies, no reactions were observed that were considered significantly allergic after testing with 8% Styrax.
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Kligman, A. M. (1966). "The identification of contact allergens by human assay. III. The maximization test: a procedure for screening and rating contact sensitizers". J. Invest. Dermatol. 47: 393–409.
- GLP compliance:
- no
- Type of study:
- other: Human maximisation test
- Justification for non-LLNA method:
- The study was conducted before REACH came into force and before OECD test guideline 429 was published.
- Specific details on test material used for the study:
- TEST MATERIAL
STYRAX HONDURAS EX HEXANE 81-8-PROD-1 - Species:
- other: human
- Strain:
- other: not applicable
- Sex:
- male/female
- Details on test animals and environmental conditions:
- 29 healthy male and female volunteers were screened and 25 completed the study. However results of 24 subjects were presented in the report.
- Route:
- epicutaneous, occlusive
- Vehicle:
- unchanged (no vehicle)
- Concentration / amount:
- 8%
- Day(s)/duration:
- for 5 alternate day 48 hour periods
- Adequacy of induction:
- not specified
- No.:
- #1
- Route:
- epicutaneous, occlusive
- Vehicle:
- unchanged (no vehicle)
- Concentration / amount:
- 8%
- Day(s)/duration:
- 48 hours
- Adequacy of challenge:
- other: challenge site was not pretreated
- No.:
- #2
- Route:
- epicutaneous, occlusive
- Vehicle:
- unchanged (no vehicle)
- Concentration / amount:
- 8%
- Day(s)/duration:
- 48 hours
- Adequacy of challenge:
- other: challenge site was pretreated with 3% sodium lauryl sulfate
- No. of animals per dose:
- 25 volunteers completed the study, results of 24 volunteers are presented in the study report.
- Details on study design:
- The materials were pretested on all subjects in order to determine whether sodium lauryl sulfate (SLS) pre-treatment was required. A patch of each material was applied to normal sites on the backs for 48 hours under occlusion. No significant evidence of irritation was observed and all subjects were pre-treated with 3% SLS.
The materials were applied under occlusion to the same site on the volar aspect of the forearms of all subjects for 5 alternate day 48 hour periods. Patch sites were pre-treated for 24 hours with 3% aqueous SLS under occlusion for the initial patch only.
Following a 10-14 day rest period, challenge patches of all materials were applied under occlusion to fresh sites for 48 hours. Challenge applications were preceded by 30 minute applications of 3% aqueous SLS under occlusion without SLS treatment on the right side. Questionable reactions were followed and retests will be applied.
Patch material: Webril cloth
Induction patch 1,5 inch square with 1.0 mL test solution
Challenge patch 1,0 inch square with 0.4 mL test solution - Positive control substance(s):
- not required
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 8%
- No. with + reactions:
- 0
- Total no. in group:
- 24
- Remarks on result:
- other: In this study the SLS was not particularly irritating giving burn reactions in about 20% of the subjects.
- Reading:
- 1st reading
- Hours after challenge:
- 48
- Group:
- negative control
- No. with + reactions:
- 0
- Total no. in group:
- 24
- Remarks on result:
- no indication of skin sensitisation
- Reading:
- 1st reading
- Group:
- positive control
- Remarks on result:
- not measured/tested
- Remarks:
- not applicable
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- Preparation 81-8-PROD-1, STYRAX HONDURAS EX HEXANE, gave no reactions that were considered significantly allergic or irritant in the 24 subjects tested.
- Executive summary:
A Human maximisation test was performed according to the Kligman, 1966 procedure. 29 healthy male and female volunteers were screened and 25 completed the study. However results of 24 subjects were presented in the report. The materials were pretested on all subjects in order to determine whether sodium lauryl sulfate (SLS) pre-treatment was required. A patch of each material was applied to normal sites on the backs for 48 hours under occlusion. No significant evidence of irritation was observed and all subjects were pre-treated with 3% SLS. The materials were applied under occlusion to the same site on the volar aspect of the forearms of all subjects for 5 alternate day 48 hour periods. Patch sites were pre-treated for 24 hours with 3% aqueous SLS under occlusion for the initial patch only. Following a 10-14 day rest period, challenge patches of all materials were applied under occlusion to fresh sites for 48 hours. Challenge applications were preceded by 30 minute applications of 3% aqueous SLS under occlusion without SLS treatment on the right side. Questionable reactions were followed and retests will be applied. In this study the SLS was not particularly irritating giving burn reactions in about 20% of the subjects. Preparation 81-8-PROD-1, STYRAX HONDURAS EX HEXANE, gave no reactions that were considered significantly allergic or irritant in the 24 subjects tested.
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Kligman, A. M. (1966). "The identification of contact allergens by human assay. III. The maximization test: a procedure for screening and rating contact sensitizers". J. Invest. Dermatol. 47: 393–409.
- GLP compliance:
- no
- Type of study:
- other: Human maximisation test
- Justification for non-LLNA method:
- The study was conducted before REACH came into force and before OECD test guideline 429 was published.
- Specific details on test material used for the study:
- TEST MATERIAL
S-TYRAX ABS. RESIN, 76-8-288 - Species:
- other: human
- Strain:
- other: not applicable
- Sex:
- not specified
- Details on test animals and environmental conditions:
- Thirty-five healthy inmate volunteers were screened and twenty-seven completed the study.
- Route:
- epicutaneous, occlusive
- Vehicle:
- petrolatum
- Concentration / amount:
- 8%
- Day(s)/duration:
- for 5 alternate day 48 hour periods
- Adequacy of induction:
- not specified
- No.:
- #1
- Route:
- epicutaneous, occlusive
- Vehicle:
- petrolatum
- Concentration / amount:
- 8%
- Day(s)/duration:
- 48 hours
- Adequacy of challenge:
- other: Challenge site was not pretreated.
- No.:
- #2
- Route:
- epicutaneous, occlusive
- Vehicle:
- petrolatum
- Concentration / amount:
- 8%
- Day(s)/duration:
- 48 hours
- Adequacy of challenge:
- other: Challenge site was pretreated with 5% sodium lauryl sulfate
- No. of animals per dose:
- 27 volunteers completed the study
- Details on study design:
- The materials were applied under occlusion to the same site on the volar aspect of the forearms of all subjects for 5 alternate day 48 hour periods. Patch sites were pre-treated for 24 hours with 5% aqueous SLS under occlusion for the initial patch only.
Following a 10-14 day rest period, challenge patches of all materials were applied under occlusion to fresh sites for 48 hours. Challenge applications were preceded by 30 minute applications of 5% aqueous SLS under occlusion on the left side of the back whereas the test materials were applied with SLS treatment on the left and petrolatum on the right and labelled site 5. Questionable reactions were biopsied and followed daily for 1 week with retest at a separate site at a later time.
Patch material: Webril cloth
Induction patch 1,5 inch square with 1.0 mL test solution
Challenge patch 1,0 inch square with 0.4 mL test solution - Challenge controls:
- Challenge applications were preceded by 30 minute applications of 5% aqueous SLS under occlusion on the left side of the back whereas the test materials were applied with SLS treatment on the left and petrolatum on the right and labelled site 5.
- Positive control substance(s):
- not required
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 8%
- No. with + reactions:
- 3
- Total no. in group:
- 27
- Remarks on result:
- positive indication of skin sensitisation
- Reading:
- 1st reading
- Hours after challenge:
- 48
- Group:
- negative control
- No. with + reactions:
- 0
- Total no. in group:
- 27
- Remarks on result:
- no indication of skin sensitisation
- Reading:
- 1st reading
- Group:
- positive control
- Remarks on result:
- not measured/tested
- Remarks:
- Not applicable
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- Preparations STYRAX ABS. RESIN sensitized 3 of the 27 subjects tested and should be considered a mild sensitizer.
- Executive summary:
A Human maximisation test was performed according to the Kligman, 1966 procedure. The materials were presented on all subjects in order to determine whether sodium lauryl sulfate (SLS) pre-treatment was required. A patch of each material was applied to normal sites on the backs for 48 hours under occlusion. No significant evidence of irritation was observed and all subjects were pre-treated with 5% SLS. The materials were applied under occlusion to the same site on the volar aspect of the forearms of all subjects for 5 alternate day 48 hour periods. Patch sites were pre-treated for 24 hours with 5% aqueous SLS under occlusion for the initial patch only. Following a 10-14 day rest period, challenge patches of all materials were applied under occlusion to fresh sites for 48 hours. Challenge applications were preceded by 30 minute applications of 5% aqueous SLS under occlusion on the left side of the back whereas the test materials were applied with SLS treatment on the left and petrolatum on the right. Questionable reactions were biopsied and followed daily for 1 week with retest at a separate site at a later time. In this study SLS produced a moderate degree of irritation to subjects #5 and 7 who gave definate + allergic reactions at site the site with STYRAX (76-8-288) and 1 subject #25 gave a 1+ allergic reaction at the SLS treated site and a ± reaction at the non SLS treated site. However by biopsy and repeat patch testing it was apparent that he also had become sensitized to the material. Preparations STYRAX ABS. RESIN sensitized 3 of the 27 subjects tested and should be considered a mild sensitizer.
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Kligman, A. M. (1966). "The identification of contact allergens by human assay. III. The maximization test: a procedure for screening and rating contact sensitizers". J. Invest. Dermatol. 47: 393–409.
- GLP compliance:
- no
- Type of study:
- other: Human maximisation test
- Justification for non-LLNA method:
- The study was conducted before REACH came into force and before OECD test guideline 429 was published.
- Specific details on test material used for the study:
- TEST MATERIAL
STYRAX ALC. SOL. TURKISH IN DEP. 78-8-8283 - Species:
- other: human
- Strain:
- other: not applicable
- Sex:
- male/female
- Details on test animals and environmental conditions:
- 29 healthy male and female volunteers were screened and 25 completed the study.
Age 20 - 69
Gender: 10 males, 15 females - Route:
- epicutaneous, occlusive
- Vehicle:
- petrolatum
- Concentration / amount:
- 8%
- Day(s)/duration:
- for 5 alternate day 48 hour periods
- Adequacy of induction:
- not specified
- No.:
- #1
- Route:
- epicutaneous, occlusive
- Vehicle:
- petrolatum
- Concentration / amount:
- 8%
- Day(s)/duration:
- 48 hours
- Adequacy of challenge:
- other: Challenge site was not pretreated
- No.:
- #2
- Route:
- epicutaneous, occlusive
- Vehicle:
- petrolatum
- Concentration / amount:
- 8%
- Day(s)/duration:
- 48 hours
- Adequacy of challenge:
- other: Challenge site was pretreated with 2% sodium lauryl sulfate
- No. of animals per dose:
- 25 volunteers completed the study
- Details on study design:
- The materials were presented on all subjects in order to determine whether sodium lauryl sulfate (SLS) pre-treatment was required. A patch of each material was applied to normal sites on the backs for 48 hours under occlusion. No significant evidence of irritation was observed and all subjects were pre-treated with 5% SLS.
The materials were applied under occlusion to the same site on the volar aspect of the forearms of all subjects for 5 alternate day 48 hour periods. Patch sites were pre-treated for 24 hours with 5% aqueous SLS under occlusion for the initial patch only.
Following a 10-14 day rest period, challenge patches of all materials were applied under occlusion to fresh sites for 48 hours. Challenge applications were preceded by 30 minute applications of 2% aqueous SLS under occlusion on the left side of the back whereas the test materials were applied without SLS treatment on the right side. Additional SLS controls were placed on the left and petrolatum on the right and labeled site 5.
Patch material: Webril cloth
Induction patch 1,5 inch square with 1.0 mL test solution
Challenge patch 1,0 inch square with 0.4 mL test solution - Challenge controls:
- SLS controls were placed on the left and petrolatum on the right and labeled site 5.
- Positive control substance(s):
- not required
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 8%
- No. with + reactions:
- 0
- Total no. in group:
- 25
- Clinical observations:
- The test material produced one irritant reaction in subject #22
- Reading:
- 1st reading
- Hours after challenge:
- 48
- Group:
- negative control
- No. with + reactions:
- 0
- Total no. in group:
- 25
- Remarks on result:
- no indication of skin sensitisation
- Reading:
- 1st reading
- Group:
- positive control
- Remarks on result:
- not measured/tested
- Remarks:
- not applicable
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- No significant reactions were seen except in one subject, the site appeared irritated. It can be concluded that STYRAX ALC. SOL. TURKISH IN DEP. produced one irritant reaction.
- Executive summary:
A Human maximisation test was performed according to the Kligman, 1966 procedure. 29 healthy male and female volunteers were screened and 25 completed the study. The materials were presented on all subjects in order to determine whether sodium lauryl sulfate (SLS) pre-treatment was required. A patch of each material was applied to normal sites on the backs for 48 hours under occlusion. No significant evidence of irritation was observed and all subjects were pre-treated with 5% SLS. The materials were applied under occlusion to the same site on the volar aspect of the forearms of all subjects for 5 alternate day 48 hour periods. Patch sites were pre-treated for 24 hours with 5% aqueous SLS under occlusion for the initial patch only. Following a 10-14 day rest period, challenge patches of all materials were applied under occlusion to fresh sites for 48 hours. Challenge applications were preceded by 30 minute applications of 2% aqueous SLS under occlusion on the left side of the back whereas the test materials were applied without SLS treatment on the right side. Additional SLS controls were placed on the left and petrolatum on the right. No significant reactions were seen except in one subject, the site appeared irritated. It can be concluded that STYRAX ALC. SOL. TURKISH IN DEP. produced one irritant reaction.
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Kligman, A. M. (1966). "The identification of contact allergens by human assay. III. The maximization test: a procedure for screening and rating contact sensitizers". J. Invest. Dermatol. 47: 393–409.
- GLP compliance:
- no
- Type of study:
- other: Human maximisation test
- Justification for non-LLNA method:
- The study was conducted before REACH came into force and before OECD test guideline 429 was published.
- Specific details on test material used for the study:
- TEST MATERIAL
STYRAX TURKISH EX HEXANE 81-8-PROD-2 - Species:
- other: human
- Strain:
- other: not applicable
- Sex:
- male/female
- Details on test animals and environmental conditions:
- 30 healthy male and female volunteers were screened and 26 completed the study.
- Route:
- epicutaneous, occlusive
- Vehicle:
- not specified
- Concentration / amount:
- 8%
- Day(s)/duration:
- for 5 alternate day 48 hour periods
- Adequacy of induction:
- not specified
- No.:
- #1
- Route:
- epicutaneous, occlusive
- Vehicle:
- petrolatum
- Concentration / amount:
- 8%
- Day(s)/duration:
- 48 hours
- Adequacy of challenge:
- other: challenge site was not pretreated.
- No.:
- #2
- Route:
- epicutaneous, occlusive
- Vehicle:
- petrolatum
- Concentration / amount:
- 8%
- Day(s)/duration:
- 48 hours
- Adequacy of challenge:
- other: Challenge site was pretreated with 3% sodium lauryl sulfate
- No. of animals per dose:
- 26 volunteers completed the study. Results of 25 volunteers are presented in the study report.
- Details on study design:
- The materials were pretested on all subjects in order to determine whether sodium lauryl sulfate (SLS) pre-treatment was required. A patch of each material was applied to normal sites on the backs for 48 hours under occlusion. No significant evidence of irritation was observed and all subjects were pre-treated with 3% SLS.
The materials were applied under occlusion to the same site on the volar aspect of the forearms of all subjects for 5 alternate day 48 hour periods. Patch sites were pre-treated for 24 hours with 3% aqueous SLS under occlusion for the initial patch only.
Following a 10-14 day rest period, challenge patches of all materials were applied under occlusion to fresh sites for 48 hours. Challenge applications were preceded by 30 minute applications of 3% aqueous SLS under occlusion without SLS treatment on the right side.
Patch material: Webril cloth
Induction patch 1,5 inch square with 1.0 mL test solution
Challenge patch 1,0 inch square with 0.4 mL test solution - Positive control substance(s):
- not required
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 8%
- No. with + reactions:
- 0
- Total no. in group:
- 25
- Remarks on result:
- other: In this group approximately one-third of the subjects were irritated by SLS. However no other significant reactions were observed.
- Reading:
- 1st reading
- Hours after challenge:
- 48
- Group:
- negative control
- No. with + reactions:
- 0
- Total no. in group:
- 25
- Remarks on result:
- no indication of skin sensitisation
- Reading:
- 1st reading
- Group:
- positive control
- Remarks on result:
- not measured/tested
- Remarks:
- not applicable
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- Preparation 81-8-PROD-2, STYRAX TURKISH EX HEXANE, produced no reactions that were considered significantly allergic or irritant in the 25 subjects tested.
- Executive summary:
A Human maximisation test was performed according to the Kligman, 1966 procedure. 30 healthy male and female volunteers were screened and 26 completed the study. The materials were pretested on all subjects in order to determine whether sodium lauryl sulfate (SLS) pre-treatment was required. A patch of each material was applied to normal sites on the backs for 48 hours under occlusion. No significant evidence of irritation was observed and all subjects were pre-treated with 3% SLS. The materials were applied under occlusion to the same site on the volar aspect of the forearms of all subjects for 5 alternate day 48 hour periods. Patch sites were pre-treated for 24 hours with 3% aqueous SLS under occlusion for the initial patch only. Following a 10-14 day rest period, challenge patches of all materials were applied under occlusion to fresh sites for 48 hours. Challenge applications were preceded by 30 minute applications of 3% aqueous SLS under occlusion without SLS treatment on the right side. In this group approximately one-third of the subjects were irritated by SLS. However no other significant reactions were observed. One subject #20 failed to receive challenge patches and will be retested in the near future. Preparation 81-8-PROD-2, STYRAX TURKISH EX HEXANE, produced no reactions that were considered significantly allergic or irritant in the 25 subjects tested.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Four human maximisation tests are available and performed according to the Kligman, 1966 procedure. These studies are used in a weigh of evidence approach to determine the sensitising potential of Styrax:
Reference
Test substance
Method
Participants
conclusion
Epstein, 1976
8% STYRAX ABS. RESIN
HMT, Klingman, 1966 procedure
27
Mild sensitizer (3/27 sensitisation reactions)
Epstein, 1978
8% STYRAX ALC. SOL. TURKISH IN DEP
HMT, Klingman, 1966 procedure
25
Not sensitising
Epstein, 1981
8% 81-8-PROD-1, STYRAX HONDURAS EX HEXANE
HMT, Klingman, 1966 procedure
24
Not sensitising
Epstein, 1981
8% 81-8-PROD-2, STYRAX TURKISH EX HEXANE
HMT, Klingman, 1966 procedure
25
Not sensitising
Three studies performed with 8% test susbtance showed no reactions that were considered significantly sensitising. The Epstein, 1976 study showed a sensitising effect in 3 out of 27 volunteers after exposure to 8% STYRAX ABS. RESIN. It was concluded that STYRAX ABS. RESIN is a mild sensitiser.
According to ECETOC 2002, classification is given when more than 5% of the volunteers have a positive response therefore Styrax is considered not skin sensitising.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
In conclusion, Styrax resinoid oil should not be classified as sensitising according to the Globally Harmonized System of Classification and Labeling of Chemicals (GHS) of the United Nations and according to the criteria outlined in Annex I of the CLP Regulation (1272/2008/EC).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.