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EC number: 225-167-9 | CAS number: 4696-57-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
No acute toxicity studies with barium dilaurate are available, thus the acute toxicity will be addressed with existing data on the dissociation products barium and laurate.
Three studies with the assessment entity barium are available and used in a weight of evidence approach resulting in a LD50>100 and <300 mg/kg bw. The assessment entity laurate does not show signs of acute oral toxicity in experimental testing (LD50 > 2000mg/kg).
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Barium
Acute oral toxicity
There are three reliable studies for acute oral toxicity testing (Müller, 1983, Borzelleca, 1988 and Tardiff, 1980). All studies are used in a weight of evidence approach. The study performed by Müller, 1983 results in an LD50of 645 mg BaCl2/kg bw (male/female), the study performed by Borzelleca in 1988 leads to an LD50>100 and <300 mg/kg bw, whereas the study conducted by Tardiff 1980 results in an LD50 of 300 mg/kg bw.
Laurate
According to the HERA document on fatty acid salts (2002) “the available data for fatty acids provide a clear picture of low acute toxicity for this class of chemicals. All oral LD50values were greater than 2,000 mg/kg, with little mortality being observed even at the highest doses tested in the studies (IUCLID, 2000c, 2000e, 2000f, 2000g; Clayton & Clayton, 1982; CIR, 1987) (HERA, 2002).
“In an OECD TG 401 study, a group of five rats/sex was administered dodecanoic acid at a dose of 5000 mg/kg bw. There were no deaths. Transient slight piloerection was observed. At necropsy, stomach mucous membrane appeared slightly reddened. The LD50was > 5000 mg/kg bw (OECD SIDS, 2014)
“International-BioResearch (1974, as referred to by CIR, 1987) determined the acute oral toxicity in groups of five male albino rats. Animals were administered by gavage lauric-, myristic-, palmitic- or stearic acid with increasing doses of up to 10,000 mg/kg bw and oleic acid up to 20,000 mg/kg bw. It was observed that for all these fatty acids the LD50value was above the maximum level tested. Therefore, the EFSA Panel noted that lauric acid and the other fatty acids have a low acute toxicity” (EFSA ANS Panel, 2017).
Barium dilaurate
Three studies with the assessment entity barium are available and used in a weight of evidence approach resulting in a LD50>100 and <300 mg/kg bw. The assessment entity laurate has not shown signs of acute oral toxicity in experimental testing (LD50 > 2000mg/kg).
The calculated acute oral toxicity for barium dilaurate as category 4 for acute oral toxicity is in line with the legally binding harmonised classification of barium salts ((EC) No 1272/2008; Index No. 056-002-00-7).
Justification for classification or non-classification
The LD50 for barium dilaurate is LD50≥340 mg/ kg bw, hence the substance is classified as acute toxic via the oral route Category 4 according to the Regulation (EC) 1272/2008 (Cat.4; H302).
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