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EC number: 202-947-7 | CAS number: 101-50-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Qualifier:
- according to guideline
- Guideline:
- other: Given below
- Principles of method if other than guideline:
- Prediction is done using QSAR Toolbox version 3.3
- GLP compliance:
- not specified
- Type of study:
- guinea pig maximisation test
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Route:
- epicutaneous, open
- Route:
- epicutaneous, open
- Reading:
- 1st reading
- Group:
- test chemical
- Clinical observations:
- Not sensitizing
- Remarks on result:
- other: Reading: 1st reading. Group: test group. Clinical observations: Not sensitizing .
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
- Conclusions:
- The skin sensitization potential for 4-Aminoazobenzene-3, 4’-disulfonic acid was estimated to be non sensitizing in guinea pig.
- Executive summary:
The skin sensitization potential for 4-Aminoazobenzene-3, 4’-disulfonic acid (101-50-8)is estimated using OECD QSAR toolbox version 3.3.The substance 4-aminoazobenzene-3, 4’-disulphonic acid is estimated to be not sensitizing to guinea pig.
Reference
The prediction was based on dataset comprised from the following descriptors: "S M W N"
Estimation method: Takes highest mode value from the 6 nearest neighbours
Domain logical expression:Result: In Domain
(((("a" or "b" or "c" or "d" or "e" or "f" ) and ("g" and ( not "h") ) ) and ("i" and ( not "j") ) ) and ("k" and "l" ) )
Domain logical expression index: "a"
Referential boundary: The target chemical should be classified as Anilines (Acute toxicity) by US-EPA New Chemical Categories
Domain logical expression index: "b"
Referential boundary: The target chemical should be classified as Aniline AND Aryl AND Azo AND Sulfonic acid by Organic Functional groups
Domain logical expression index: "c"
Referential boundary: The target chemical should be classified as Aniline AND Aryl AND Azo AND Overlapping groups AND Sulfonic acid by Organic Functional groups (nested)
Domain logical expression index: "d"
Referential boundary: The target chemical should be classified as Aliphatic Nitrogen, one aromatic attach [-N] AND Aromatic Carbon [C] AND Azo [-N=N-] AND Hydroxy, sulfur attach [-OH] AND Miscellaneous sulfide (=S) or oxide (=O) AND Olefinic carbon [=CH- or =C<] AND Suflur {v+4} or {v+6} AND Sulfinic acid [-S(=O)OH] AND Sulfonate, aromatic attach [-SO2-O] by Organic functional groups (US EPA)
Domain logical expression index: "e"
Referential boundary: The target chemical should be classified as Amine AND Aromatic compound AND Azo compound AND Primary amine AND Primary aromatic amine AND Sulfonic acid AND Sulfonic acid derivative by Organic functional groups, Norbert Haider (checkmol)
Domain logical expression index: "f"
Referential boundary: The target chemical should be classified as Aromatic amines AND Sulfonic acids or their salts by Skin irritation/corrosion Inclusion rules by BfR
Domain logical expression index: "g"
Referential boundary: The target chemical should be classified as No Data by Ultimate biodeg
Domain logical expression index: "h"
Referential boundary: The target chemical should be classified as > 100 days OR 1 to 10 days OR 10 to 100 days by Ultimate biodeg
Domain logical expression index: "i"
Referential boundary: The target chemical should be classified as Aromatic amines AND Sulfonic acids or their salts by Skin irritation/corrosion Inclusion rules by BfR
Domain logical expression index: "j"
Referential boundary: The target chemical should be classified as Ketones OR Phenols by Skin irritation/corrosion Inclusion rules by BfR
Domain logical expression index: "k"
Parametric boundary:The target chemical should have a value of log Kow which is >= -1.88
Domain logical expression index: "l"
Parametric boundary:The target chemical should have a value of log Kow which is <= 1.25
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Skin sensitization
The skin sensitization potential for4-Aminoazobenzene-3, 4’-disulfonic acid (101-50-8)is estimated using OECD QSAR toolbox version 3.3.The substance 4-aminoazobenzene-3, 4’-disulphonic acid is estimated to be not sensitizing to guinea pig.
In other study by (.SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS, 2004) with similar substance (1934-24-0) was assayed in guineapigs.Maximisation test was conducted according to OECD guideline 406 to the skin of Albino guinea pigs. A 5 % Acid Yellow 23 solution was applied in an emulsion of Freund´s Complete Adjuvant (FCA) for the intradermal induction. 1 week later, following treatment with sodium lauryl sulfate (SLS) the epidermal induction was conducted for 48 h under occlusion with a 50 % Acid Yellow 23 solution. 2 wk later the animals were challenged by epidermal application of Acid Yellow 23(5% solution) under occlusive dressing. Cutaneous reactions were evaluated at 24 and 48 h after removal of the dressing. For challenge reading, all animals were depilated 3 h before examination to remove the discolouration.None of the control and test animals showed skin reactions after the challenge treatment with Acid Yellow 23. The 50 % test item stained the skin orange, therefore it was not possible to determine whether erythema were present or not. However, no oedema was observed.Hence, Non-sensitising effects were known skin sensitisation test of chemical tartrazineMaximisation (Magnusson and Kligman) Test.
In other study by (.SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS, 2004) with similar substance (1934-24-0) was assayed in human.Human patch test was conducted was conducted to study the skin sensitisation of chemical Acid yellow 23.32 patients (20 women, 12 men) with a positive patch test reaction to paminoazobenzene were tested with dose concentration of 2%.Patch tests were performed using uniform patch tests,Acid Yellow 23 did not elicit an allergic reaction .Hence,Non-sensitising effects were known skin sensitisation test of chemical tartrazinein Human patch test.
In other study by (.S. Pestana, M. Moreira, B. Oleja , 2010) with similar substance (1934-24-0) was assayed . In an in vivo Double-blind placebo controlled challenge test, 26 atopic adults were treated by using Tartrazine in the concentration of 5, 10, 20 and 35 mg and challenged by using placebo (talc) in vice-versa withTartrazine and examined for Erythematous rash, Pruritus and Urticaria/angioedema fifty minutes after the ingestion of each capsule, and 2 h after the last one. No Erythematous rash, Pruritus and Urticaria/angioedema were observed in treated atopic adults. Therefore,Tartrazine was considered to be non sensitizing when atopic adults were tested by using Double-blind placebo controlled challenge.
On the basis of available information for the target as well as read across substance and applying weight of evidence approach, the test substance can be considered as not sensitising to the skin.
Migrated from Short description of key information:
The skin sensitization potential for 4-Aminoazobenzene-3, 4’-disulfonic acid (101-50-8)is estimated using OECD QSAR toolbox version 3.3.The substance 4-aminoazobenzene-3, 4’-disulphonic acid is estimated to be not sensitizing to guinea pig.
Justification for selection of skin sensitisation endpoint:
The skin sensitization potential for 4-Aminoazobenzene-3, 4’-disulfonic acid (101-50-8)is estimated using OECD QSAR toolbox version 3.3.The substance 4-aminoazobenzene-3, 4’-disulphonic acid is estimated to be not sensitizing to guinea pig.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
The test substance 4-Aminoazobenzene-3, 4’-disulfonic acid can be classified as not sensitizer.
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