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Diss Factsheets
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EC number: 212-603-8 | CAS number: 831-52-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from computational model developed by USEPA
- Justification for type of information:
- Data is from computational model developed by USEPA
- Qualifier:
- according to guideline
- Guideline:
- other: Modeling database
- Principles of method if other than guideline:
- ECOSAR v1.00
- GLP compliance:
- no
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- other: Fish
- Test type:
- not specified
- Water media type:
- freshwater
- Total exposure duration:
- 96 h
- Hardness:
- no data
- Test temperature:
- no data
- pH:
- no data
- Dissolved oxygen:
- no data
- Salinity:
- no data
- Nominal and measured concentrations:
- no data
- Details on test conditions:
- no data
- Reference substance (positive control):
- not specified
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 1 920.657 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: ECOSAR Class: Neutral Organic SAR(Baseline Toxicity)
- Conclusions:
- Based on the QSAR prediction done using the EPI Suite ECOSAR version 1.10, the 96 hours LC50 was estimated to be 1920.657 mg/l in freshwater on fish for substance with mortality effects.
- Executive summary:
Based on the prediction done by EPI suite, ECOSAR version 1.1, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program, the LC 50 value for short term toxicity to fish was predicted. On the basis of this program, the LC50 value for short term toxicity to aquatic invertebrates was predicted to be 1920.657 mg/l for test material in 48 hrs. Based on the above effect concentration value it can be predicted test substance is not toxic to fish and can not be classified as per CLP criteria.
Reference
Description of key information
Short term toxicity to fish:
Based on the p iction done by EPI suite, ECOSAR version 1.1, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program, the LC 50 value for short term toxicity to fish was predicted. On the basis of this program, the LC50 value for short term toxicity to aquatic invertebrates was predicted to be1920.657mg/l for test material in 48 hrs. Based on the above effect concentration value it can be predicted test substance is not toxic to fish and can not be classified as per CLP criteria.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 1 920.657 mg/L
Additional information
Short term toxicity to fish:
The toxicity of test material was evaluated for fish based on the predicted data and data for structurally similar read across substance from peer reviewed journal
Based on the piction done by EPI suite, ECOSAR version 1.1, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program, the LC 50 value for short term toxicity to fish was predicted. On the basis of this program, the LC50 value for short term toxicity to aquatic invertebrates was predicted to be1920.657mg/l for test material in 48 hrs. Based on the above effect concentration value it can be predicted test substance is not toxic to fish and can not be classified as per CLP criteria.
The short term toxicity of test material on fish Oncorhynchus mykiss (Rainbow trout) was observed for 96 h Juvenile rainbow trout (x = 41.6±8.7 mm total length) were selected .Rainbow trout were held in the laboratory at an approximate density o 3 g/l in continuous flow, non - chlorinated deep well water with 99 percent replacement of the water every 12 h. The fish were acclimatized for 2 weeks in the same conditions as test ,during acclimation, the trout were fed commercial trout chow daily, static renewations were conducted. In an effort to control possible volatilization, the aquaria were fitted with glass covers. Test chambers were placed in two 4 x 0.8 x 0.25 m circulated constant temperature baths. The dilution water used during the tests was the same as that used for acclimation.Two replicates composed of a total of 25 fish (N = 13 and 12) were randomly selected from the test population and placed in the aquaria containing the test solutions. The nominal test concentrations for test material were 0, 75, 85, 95, 105, 115, and 125 mg/l. The lethal effect concentration (LC50) observed after 96 h was noted to be 135.0 mg/l. As no mortalities were observed till the concentration 135.0 mg/l , it can be concluded that the test material is not classified as per CLP criteria.
For another structurally similar read across substance, the short term toxicity of test material on fish Oncorhynchus mykiss (Rainbow trout) was observed for 96 h Juvenile rainbow trout (x = 41.6±8.7 mm total length) were selected .Rainbow trout were held in the laboratory at an approximate density o 3 g/l in continuous flow, non - chlorinated deep well water with 99 percent replacement of the water every 12 h. The fish were acclimatized for 2 weeks in the same conditions as test ,during acclimation, the trout were fed commercial trout chow daily, static renewations were conducted. In an effort to control possible volatilization, the aquaria were fitted with glass covers. Test chambers were placed in two 4 x 0.8 x 0.25 m circulated constant temperature baths. The dilution water used during the tests was the same as that used for acclimation.Two replicates composed of a total of 25 fish (N = 13 and 12) were randomly selected from the test population and placed in the aquaria containing the test solutions. The nominal test concentrations for test material were 0, 75, 85, 95, 105, 115, and 125 mg/l. The lethal effect concentration (LC50) observed after 96 h was noted to be 135.0 mg/l.
As no mortalities were observed till the concentration 219.2 mg/l , it can be concluded that the test material is not classified as per CLP criteria.
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