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EC number: 430-500-8 | CAS number: 204277-61-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 20 January 1999 to 10 February 1999
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP methodology followed and OCED guideline 402 used to performed the experiment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 430-500-8
- EC Name:
- -
- Cas Number:
- 204277-61-2
- Molecular formula:
- Hill formula: C23 H23 Cl N6 O8 CAS formula: C23 H23 Cl N6 O8
- IUPAC Name:
- methyl 2-({4-[2-(2-chloro-6-cyano-4-nitrophenyl)diazen-1-yl]-5-acetamido-2-methoxyphenyl}(2-methoxy-2-oxoethyl)amino)propanoate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Identification: FAT 41024/B
Batch number: ARL 83-PP 1/98
Purity: Approx 94%
Colr / Physical form: Balck/Solid
Stability of the testarticle: Stable under storage conditions
Stability of the test article dilution: 24 hours at room temperature
Expiry date: September 04, 2004
Storage conditions: At room temperature away from direct sunlight
Safety precations: Gloves, goggles and face mask.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: HanIbm: WIST (SPF)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Source: BRL, Biological Research Laboratories Ltd., Wölferstrasse 4, CH-4414 Switzerland
- Age when treated: 9 weeks (male) and 12 weeks (female)
- Body weight rage when treated: 230.9-246.8 g (male) and 193.5-206.1 g (female)
- Identification: By unique cage number and corresponding color-coded spots on the tail.
- Acclimatization: 7 days under laboratory conditions, after health examination.
- Diet: ad libitum
- Water : ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22°C +/- 3°C
- Humidity (%):40-70%
- Air changes (per hr):10-15 air changes per hour
- Photoperiod (hrs dark / hrs light):12 hour light and 12 hour dark, music was palyed approximately 8 hours during the light period.
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- polyethylene glycol
- Remarks:
- PEG 300
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Backs of the animals
- % coverage: 10% of the total body surface
- Type of wrap if used: semi-occlusive dressing
REMOVAL OF TEST SUBSTANCE
24 hours after the application the dressing was removed and the skin was washed with lukewarm tap water and dried with disposable paper towels.
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 4.0 ml. The test article was prepared in vehicle PEG 300 - Duration of exposure:
- 24 hours
- Doses:
- Rats were treated with FAT 41024/B at 2000 mg/kg by dermal application.
- No. of animals per sex per dose:
- 5 males and 5 females.
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
Mortality/Viability: Four times during test day 1 and once daily during days 2-15
Body weight: On test day 1 (pre-administartion), 8 and 15.
Clinical signs: Each animal was examined for changing in appearance and behaviour four times during day 1, and once daily during days 2-15. All abnormalities were reccorded.
- Necropsy of survivors performed: yes Necropsy were performed by experineced prosectors. At the end of teh observation period all animals were sacrified by intrperitoneal injection of NARCOREN at a dose of at least 2.0 ml/kg body weight (equivalent to at least 320mg sodium pentobarbitone/kg body weight)
- Other examinations performed: clinical signs, body weight. - Statistics:
- No statistical analysis was used as no deaths occured.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths occured during the study.
- Clinical signs:
- other: In all animals, residual test article was observed on the treated skin on test day two and persisted in two females until test day 14. No systemic signs of toxicity were observed during the study period.
- Gross pathology:
- No macroscopic finding were observed at necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- The median lethal dose of FAT 41024/B after single dermal administartion to rats of both sexes, observed over a period of 14 days, could not be estimated as no deaths occured. LD50 is greater than 2000 mg/kg.
- Executive summary:
The purpose of this study was to assess the acute dermal toxicty of FAT 41024/B when administred to rats by a single semi-occlusive dermal application, followed by an observation period of 14 days.
This experiment was performed according to the OECD Guideline 402 (Acute Dermal Toxicity).
A group of five male and five female HanIbm: WIST (SPF) rats was treated with FAT 41024/B at 2000 mg/kg by dermal application. The test article was prepared in vehicle (PEG 300) at a concentration of 0.5 mg/ml and administred at a volume of 4 ml/kg. The animals were examined for clinical signs four times during day 1 and once daily during days 2 -15.
Mortality /Viability were recorded together with clinical signs at the same time intervals.
Body weight were recorded on day 1 prior to administration and on days 8 and 15.
All animals were necropsied and examined macroscopically.
No deaths occured during the study.
In all animals, residual test article was observed on the treated skin on test day two and persisted in two females until test day 14. No systemic signs of toxicity were observed during the study period.
The body weight of the animals was within the range commonly recorded for animals of this strain and age.
No macroscopic findings were observed at necropsy.
The median lethal dose of FAT 41024/B after single dermal administartion to rats of both sexes, observed over a period of 14 days, could not be estimated as no deaths occured. LD50 is greater than 2000 mg/kg.
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