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Diss Factsheets
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EC number: 701-085-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian germ cell study: cytogenicity / chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 478 (Genetic Toxicology: Rodent Dominant Lethal Test)
- GLP compliance:
- no
- Type of assay:
- rodent dominant lethal assay
Test material
- Reference substance name:
- Silicic acid, calcium salt
- EC Number:
- 215-710-8
- EC Name:
- Silicic acid, calcium salt
- Cas Number:
- 1344-95-2
- IUPAC Name:
- Silicic acid, Calcium salt
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data
- Age at study initiation: 10 - 12 weeks
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- - vehicle: 0.85 % saline
- Volume of the vehicle: no data
- Justification for choice of solvent/vehicle: no data
- Concentration of test material in vehicle: no data
MAXIMUM DOSE VOLUME APPLIED: no data - Duration of treatment / exposure:
- single administration ("acute") and repeated administration (5 times, "subacute")
- Frequency of treatment:
- 1x and 5x (1x/day)
Doses / concentrations
- Remarks:
- Doses / Concentrations:
150, 500 and 1500 mg/kg bw, suspended in 0.85 % saline, administered 1x/d (Test I), 5000 mg/kg bw (Test II)
Basis:
- No. of animals per sex per dose:
- 10 males (treated) mated to virgin female rats (2 females/1 male)
- Control animals:
- yes, concurrent vehicle
- yes, historical
- Positive control(s):
- triethylene melamine
- Route of administration: i.p.
- Doses / concentrations: 0.3 mg/kg bw
Examinations
- Tissues and cell types examined:
- Fertility index = No. pregnant females / No. mated
Total No. of implantations
Total number of corpora lutea
Preimplantation losses
see Report p. 132 - 135:
Dead implants
Females with one or more dead implants
Dead implants per total implants - Statistics:
- Chi-square test, Armitage´s trend test, regression analyses, Freeman-Tukey transformation, t-test (Report p. 132 - 135)
Results and discussion
Test results
- Key result
- Sex:
- male
- Genotoxicity:
- negative
- Toxicity:
- not specified
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
Any other information on results incl. tables
For single and repeated dosage of 15, 15, and 150 mg/kg bw (Report p. 80 - 99) as well as single and repeated dosage of 5000 mg/kg bw (Report p. 100 - 117),there was no dose-response and time-trend pattern of effects following the silicate treatment: The values calculated for reproduction parameters (see "Examinations" above) that related to the treated animals did not significantly vary from those obtained from the negative controls, whereas TEM caused a significant preimplantation loss and embryo resorption during the first five weeks.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results: negative
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