Registration Dossier
Registration Dossier
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EC number: 424-240-4 | CAS number: 96478-09-0
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- other: All information in this endpoint has been provided by the ECHA using the 12 year rule, this data is not owned by the registrant . The reliability is estimated to be at level 2 at a minimum.
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- All information in this endpoint has been provided by the ECHA using the 12 year rule, data are not owned by the registrant. The reliability is estimated to be at level 2 at a minimum. Therefore the reliability statement below can be used: Study conducted in accordance with generally accepted scientific principles, possibly with incomplete reporting or methodological deficiencies, which do not affect the quality of relevant results.
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Information not provided in the 12 year old data which has been provided to us by the ECHA
- GLP compliance:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 424-240-4
- EC Name:
- -
- Cas Number:
- 96478-09-0
- Molecular formula:
- C18 H17 N3 O3
- IUPAC Name:
- 2-[3-(2H-1,2,3-benzotriazol-2-yl)-4-hydroxyphenyl]ethyl 2-methylprop-2-enoate
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- not specified
- Controls:
- no
- Amount / concentration applied:
- This information was not provided in the migrated SNIF dossier (SNIF # 001-3.0.10-01) provided by ECHA
- Duration of treatment / exposure:
- This information was not provided in the migrated SNIF dossier (SNIF # 001-3.0.10-01) provided by ECHA
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- This information was not provided in the migrated SNIF dossier (SNIF # 001-3.0.10-01) provided by ECHA
- Details on study design:
- This information was not provided in the migrated SNIF dossier (SNIF # 001-3.0.10-01) provided by ECHA
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- score for all animals
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0.9
- Max. score:
- 4
- Reversibility:
- fully reversible within: 4 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- score for all animals
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0.1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 4 days
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- score for all animals
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within: 4 days
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- score for all animals
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within: 4 days
- Irritant / corrosive response data:
- Slight effects have been shown in some animals, however these effects are not enough to trigger a classification.
- Other effects:
- None
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test material has not produced any significant effects of irritation to the animals within this study, therefore the test material can be classed as not classified.
- Executive summary:
The study has been conducted according to Method B4 of Commission Directive 92/69 EEC. The test material has not produced any significant effects of irritation to the animals within this study, therefore the test material is not classified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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