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EC number: 213-156-1 | CAS number: 927-62-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study equivalent to guideline
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Dimethylamine
- EC Number:
- 204-697-4
- EC Name:
- Dimethylamine
- Cas Number:
- 124-40-3
- IUPAC Name:
- N-methylmethanamine
- Test material form:
- not specified
Constituent 1
Method
- Target gene:
- his-
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Metabolic activation system:
- rat and hamster S9 (10% Aroclor 1254-induced)
- Test concentrations with justification for top dose:
- 0, 33, 100, 333, 1000, 3333, 4500 µg/plate
- Vehicle / solvent:
- water
Controls
- Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- yes
- Remarks:
- run with each trial
- Positive controls:
- yes
- Remarks:
- without S9: Sodium azide (TA1535, TA100), 9-aminoacridine (TA1537), 4-nitro-o-phenylenediamine (TA98) with S9: 2-aminoanthracene
- Evaluation criteria:
- An individual trial was judged mutagenic (+) if a dose-related increase over the corresponding solvent control was seen, and it was judged weakly mutagenic C+W) if a low-level dose response was seen. A trial was considered questionable (?) if a dose related
increase was judged insufficiently high to justify a call of " + W," if only a single dose was elevated over the control, or if a non-dose-related increase was seen.
The distinctions between a weak mutagenic response and a mutagenic response, or between a weak mutagenic response and a questionable mutagenic response are highly subjective.
A chemical was judged to be mutagenic (+), or weakly mutagenic (+W), if it produced a reproducible, dose-related increase in his+ revertants over the corresponding solvent controls in replicate trials. A chemical was considered to be questionable (?) if a reproducible increase of hist revertants did not meet the criteria for either a " + " or " + W," or if only single doses produced an increase in his+ revertants in repeat trials - Statistics:
- not required
Results and discussion
Test results
- Species / strain:
- S. typhimurium, other: all strains tested
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- other: >1000 µg/plate
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
Table 82.1 DIMETHYLAMINE (LAB: EGG SOLVENT: H2O) |
||||||||||||||||||||||||
DOSE |
TA100 |
TA1535 |
TA1537 |
TA98 |
||||||||||||||||||||
NA |
10% HLI |
10% RLI |
NA |
10% HLI |
10% RLI |
NA |
10% HLI |
10% RLI |
NA |
10% HLI |
10% RLI |
|||||||||||||
ug/PLATE |
MEAN |
SEM |
MEAN |
SEM |
MEAN |
SEM |
MEAN |
SEM |
MEAN |
SEM |
MEAN |
SEM |
MEAN |
SEM |
MEAN |
SEM |
MEAN |
SEM |
MEAN |
SEM |
MEAN |
SEM |
MEAN |
SEM |
0.000 |
93 |
8.0 |
89 |
9.1 |
76 |
2.5 |
24 |
1.9 |
8 |
1.7 |
13 |
1.2 |
4 |
1.5 |
4 |
0.9 |
8 |
1.5 |
18 |
5.2 |
20 |
0.6 |
24 |
3.2 |
33.000 |
92 |
5.4 |
|
|
|
|
21 |
1.5 |
|
|
|
|
8 |
1.0 |
|
|
|
|
20 |
2.7 |
|
|
|
|
100.000 |
91 |
8.7 |
90 |
3.1 |
77 |
2.0 |
19 |
2.5 |
7 |
1.5 |
11 |
0.9 |
8 |
0.6 |
6 |
0.9 |
8 |
2.6 |
15 |
2.8 |
24 |
2.2 |
17 |
1.0 |
333.000 |
92 |
6.4 |
80 |
4.5 |
91 |
0.6 |
20 |
4.0 |
10 |
0.6 |
10 |
2.7 |
5 |
1.3 |
6 |
2.3 |
6 |
2.2 |
17 |
4.8 |
20 |
2.0 |
17 |
2.7 |
1000.000 |
88 |
6.3 |
92 |
7.0 |
88 |
5.2 |
16 |
2.3 |
7 |
1.2 |
8 |
1.7 |
5 |
1.5 |
8 |
0.3 |
5 |
1.7 |
17 |
1.2 |
20 |
3.9 |
24 |
3.0 |
3333.000 |
t |
|
88 |
5.2 |
89 |
11.0 |
11s |
1.5 |
8 |
1.2 |
9 |
1.3 |
6s |
0.7 |
7 |
1.5 |
10 |
0.3 |
t |
|
19 |
5.0 |
22 |
1.5 |
4500.000 |
|
|
82 |
6.7 |
86 |
2.5 |
|
|
9s |
1.8 |
8 |
2.4 |
|
|
6 |
1.3 |
6 |
3.3 |
|
|
19 |
1.2 |
20 |
1.5 |
POS |
2003 |
16.5 |
887 |
78.0 |
580 |
31.2 |
1176 |
36.1 |
80 |
1.9 |
51 |
2.7 |
573 |
199.4 |
94 |
4.2 |
58 |
8.7 |
840 |
81.5 |
1011 |
82.4 |
639 |
64.7 |
Table 82.2 DIMETHYLAMINE (LAB: EGG SOLVENT: H2O) |
||||||||||||||||||||||||
DOSE |
TA100 |
TA1535 |
TA1537 |
TA98 |
||||||||||||||||||||
NA |
10% HLI |
10% RLI |
NA |
10% HLI |
10% RLI |
NA |
10% HLI |
10% RLI |
NA |
10% HLI |
10% RLI |
|||||||||||||
ug/PLATE |
MEAN |
SEM |
MEAN |
SEM |
MEAN |
SEM |
MEAN |
SEM |
MEAN |
SEM |
MEAN |
SEM |
MEAN |
SEM |
MEAN |
SEM |
MEAN |
SEM |
MEAN |
SEM |
MEAN |
SEM |
MEAN |
SEM |
0.000 |
117 |
10.1 |
107 |
6.2 |
132 |
16.2 |
21 |
3.5 |
13 |
1.5 |
10 |
0.7 |
7 |
2.0 |
8 |
0.9 |
8 |
0.6 |
22 |
4.4 |
34 |
2.9 |
28 |
3.2 |
100.000 |
126 |
4.8 |
124 |
3.2 |
106 |
7.0 |
14 |
1.2 |
10 |
1.2 |
15 |
4.2 |
8 |
1.9 |
8 |
0.3 |
9 |
1.5 |
25 |
2.7 |
25 |
2.9 |
28 |
1.5 |
333.000 |
112 |
9.5 |
116 |
5.0 |
120 |
0.9 |
15 |
3.9 |
15 |
1.8 |
10 |
0.0 |
8 |
1.3 |
7 |
1.2 |
10 |
2.2 |
21 |
1.7 |
28 |
1.7 |
26 |
1.2 |
1000.000 |
126 |
4.4 |
136 |
4.4 |
127 |
4.3 |
18 |
3.2 |
10 |
2.0 |
10 |
1.7 |
5 |
0.3 |
5 |
0.9 |
9 |
0.6 |
22 |
0.7 |
29 |
6.2 |
31 |
1.9 |
2000.000 |
108 |
7.6 |
115 |
5.1 |
113 |
16.4 |
15s |
3.0 |
12s |
1.9 |
14 |
1.5 |
9s |
2.8 |
9 |
0.3 |
11 |
1.7 |
24s |
1.8 |
26 |
1.2 |
27 |
1.2 |
3333.000 |
97s |
11.5 |
129s |
4.7 |
117 |
14.7 |
t |
|
11s |
1.2 |
11 |
1.2 |
t |
|
7 |
0.6 |
8 |
0.6 |
20s |
1.5 |
29 |
2.4 |
27 |
1.8 |
4000.000 |
|
|
|
|
|
|
|
|
16s |
2.3 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
POS |
2012 |
55.2 |
1503 |
72.7 |
1255 |
49.0 |
1205 |
65.2 |
116 |
7.2 |
60 |
1.7 |
535 |
18.1 |
184 |
21.0 |
133 |
2.1 |
2002 |
38.4 |
1270 |
40.2 |
1022 |
55.2 |
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
Dimethylamine (and all other primary, secondary, and tertiary aliphatic amines tested in this valid study) was not mutagenic in the Ames test, with or without metabolic activation. - Executive summary:
Salmonella typhimurium TA 100, TA 1535, TA1537, TA 98 were exposed to 0, 33, 100, 333, 1000, 3333, 4000, and 45000 µg/plate using the pre-incubation method in either the presence or absence of 10% rat or hamster liver metabolic activation. The highest non-toxic dose was 1000 mg/plate. The number of revertants was not increased in any of the experiments, i.e. dimethylamine was not mutagenic in bacteria (Zeiger et al., 1987).
The study is considered to be valid and suitable for assessment and the result can be extrapolated to N,N-dimethylbutylamine. All other aliphatic amines that were included in this study were also negative. This includes the following substances: allylamine; n-butylamine; sec-butylamine; tert. butylamine; di-allylamine; 1,3-diamonopropane; di-ethylamine; 1,3-dimethylbutylamine; di-n-propylamine; ethyl-n-butylamine; isopropylamine; tri-allylamine; tri-butylamine; tri-ethylamine; tri-isobutylamine.
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