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EC number: 900-501-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
30 d, ChV (fish): 15237 mg/L (ECOSAR v1.00)
Key value for chemical safety assessment
Additional information
According to the “Guidance on information requirements and chemical safety assessment Chapter R.7b: Endpoint specific guidance”, long-term testing should be proposed if the chemical safety assessment according to Annex I of Regulation (EC) No. 1907/2006 indicates the need to investigate further the effects on aquatic organisms. Based on all information available, this is not the case for Reaction mass of 1-O-α-D-glucopyranosyl-D-fructose and 6-O-α-D-glucopyranosyl-D-fructose and fructose and glucose and sucrose.
Based on the molecular structure of the constituents, and their natural occurrence and role in common metabolic pathways, toxic effects on aquatic organisms are not to be expected. Reaction mass of 1-O-α-D-glucopyranosyl-D-fructose and 6-O-α-D-glucopyranosyl-D-fructose and fructose and glucose and sucrose is the aqueous solution (syrup) of the reaction mass of isomaltulose (CAS 13718-94-0), trehalulose (CAS 51411-23-5), fructose (CAS 57-48-7), glucose (CAS 50-99-7), sucrose (CAS 57-50-1), isomaltose (CAS 499-40-1) and oligosaccharides.
Fructose and glucose are common monosaccharides that feed into glycolysis. Glycolysis is a well described metabolic pathway used by virtually all cells, both eukaryotic and prokaryotic, to produce energy in form of ATP. Sucrose is a disaccharide formed by the glycosidic linkage of glucose and fructose. It can be cleaved into its component monosaccharides by the enzyme sucrase (Berg, Tymoczko and Stryer, 2002). Glucose, fructose and sucrose are included in Annex IV of Regulation 1907/2006/EC, as sufficient information is known about these substances, and they are considered to cause minimum risk because of their intrinsic properties. Isomaltulose is a disaccharide composed of α-1,6-linked glucose and fructose, naturally occurring in honey and sugar cane juice. As sucrose, isomaltose is cleaved to fructose and glucose by disaccharidases, and the monosacharides are metabolised following the same classical routes (Lina, Jonker and Kozianowski, 2002; and references therein). Trehalulose is the 1,1-linked glucosylfructose isomer of sucrose (1,2-linked glucosylfructose). It is expected to be hydrolysed to glucose and fructose by disaccharidases, which are ubiquitous among organisms in nature.QSAR calculations for long-term fish toxicity were performed for all main constituents of Reaction mass of 1-O-α-D-glucopyranosyl-D-fructose and 6-O-α-D-glucopyranosyl-D-fructose and fructose and glucose and sucrose, resulting in chronic values above 10000 mg/L (ECOSAR v1.00).
Moreover, based on ready biodegradability studies available for isomaltulose, trehalulose and palatinose syrup (consists mainly of glucose, fructose and sucrose), Reaction mass of 1-O-α-D-glucopyranosyl-D-fructose and 6-O-α-D-glucopyranosyl-D-fructose and fructose and glucose and sucrose is expected to be rapidly degraded in the environment. As the constituents also have low adsorption potential (log Koc 1) to sediment or suspended particles, long-term exposure of aquatic organisms is unlikely.
Additionally, short-term toxicity data available for the structurally similar substance sodium gluconate (CAS No. 527-07-1) indicate no hazard potential to fish (EC50 > 10000 mg/L).
Based on all information available on the constituents of Reaction mass of 1-O-α-D-glucopyranosyl-D-fructose and 6-O-α-D-glucopyranosyl-D-fructose and fructose and glucose and sucrose and the acute fish toxicity data available for the structural analogue sodium gluconate (CAS No. 527-07-1), Reaction mass of 1-O-α-D-glucopyranosyl-D-fructose and 6-O-α-D-glucopyranosyl-D-fructose and fructose and glucose and sucrose is not expected to have long-term effects on fish. Therefore, and for reasons of animal welfare, long-term testing of fish is not considered justified.
References:
Berg, Tymoczko and Stryer, 2002, Biochemistry (5thed.) W.H. Freeman and Company
Lina, Jonker and Kozianowski, 2002, Isomaltulose (Palatinose ®): a review of biological and toxicological studies. Food and Chemical Toxicology 40, 1375-1381
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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