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EC number: 613-645-3 | CAS number: 646505-36-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
The following remarks on toxicokinetics are based on the physico-chemical properties of Desmorapid 01 and on toxicological data. Experimental studies on toxicokinetics were not performed.
Desmorapid 01 is used as catalyst in the manufacture of polyurethanes. During the reaction of diisocyanates with polyols Desmorapid 01 is fully and tightly integrated into the polymeric matrix. Because of its complex composition Desmorapid 01 is considered a UVCB substance.
Desmorapid 01 can be chemically described as ‘butanoic acid, 3-oxo-, methylester, reaction products with N,N-dimethyl-1,3-propanediamine and propylene glycol ether with trimethylol propane (3:1) (CAS-No. 646505-36-4)’ or (different description of the same substance) ‘poly [oxy(methyl-1,2-ethanediyl)], a-hydro-w-hydroxy-, ether with 2-ethyl-2-(hydroxymethyl)-1,3-propanediol (3:1), 3-[[3-dimethylamino) propyl]imino]butanoate’ (CAS-No. 857285-61-1). The closely related CAS-No. 179733-18-7 describes the same substance and differs only in the manufacturing process where ethanol is distilled off while for the other two CAS-Nos. methanol is distilled off (see IUCLID section 1.1). Thus, toxicological data for all three CAS-Nos. are considered relevant for the substance to be registered and are taken into account for human health assessment.
Desmorapid 01 is a yellow liquid (Prüm, 2010) with a very low vapour pressure under normal ambient conditions (0.0041 Pa at 20°C, Fonseca, 2012). Inhalation exposure to the vapour is therefore not to be expected. Desmorapid 01 is not used in industrial spray processes.
Limited oral and dermal absorption can be assumed based on the high mean molecular weight of about 630 g/mole (see IUCLID section 1.1), however, the water solubility of 600 mg/L (see IUCLID section 4.8) and the mean log Pow of 2.8 (Neuland, 2013) are favourable for absorption. In fact, at least some of the substance seems to be bioavailable in rats after repeated ingestion of high doses. In a 28 day oral toxicity study (Eiben, 2011) the limit dose of 1000 mg/kg bw and day (gavage) induced slight systemic toxicity in liver and thymus, indicating bioavailability. The next lower dose of 300 mg/kg bw constitutes the NOAEL in this study. No indications of systemic availability were observed after acute oral (Bomhard, 1993) exposure of rats to 2000 mg/kg bw as there were no systemic toxicological effects reported. However, slight clinical signs as breathing sounds after acute oral administration, focal inflammation of the glandular stomach in some animals after repeated oral administration and partial skin reddening after dermal application indicate irritating properties of the substance.
The log Pow of 2.8 does not indicate a relevant bioaccumulation potential of Desmorapid 01.
In skin and eye irritation studies (Krötlinger, 1994 a, b) the substance was proven as moderate skin irritant and severe eye irritant. Acute dermal application of high doses to rats did not result in systemic toxicity (Gillissen, 2010). However, after overcoming the skin barrier, Desmorapid 01 is bioavailable as was shown in a skin sensitization study on Guinea pigs. Desmorapid 01 has to be considered as a moderate skin sensitizer in the Guinea pig maximization test (Vohr, 1993).
Based on the negative results of three in vitro genotoxicity tests performed with and without metabolic activation (Ames Test, Nern, 2011; HPRT Test, Hall, 2011; Micronucleus test, Sutter, 2011) it can be assumed that DNA-reactive metabolites of Desmorapid 01 will not be generated in mammals in the course of hepatic biotransformation.
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