Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 297-474-6 | CAS number: 93572-43-1 A complex combination of hydrocarbons obtained by refining of crude oil. It consists predominantly of aromatics, naphthenics and paraffinics and produces a finished oil with a viscosity of 120 SUS at 100°F (23cSt at 40°C).
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: other: procedure described in paper by Ames
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Summary study report
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- I U C L I D D a t a s e t Substance ID: 74869– 22–0
- Author:
- EUROPEAN COMMISSI – European Chemicals Bureau
- Year:
- 2 000
- Bibliographic source:
- I U C L I D D a t a s e t Substance ID: 74869–22–0 pag 77
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 64742–56–9
- IUPAC Name:
- 64742–56–9
- Reference substance name:
- 64742–65–0
- IUPAC Name:
- 64742–65–0
- Details on test material:
- Five substances were tested:
one sample (API 78–9) of solvent–dewaxed light paraffinic distillate, CAS No. 64742–56–9,
four samples (API 78–10, 79–3, 79–4 and 79–5) of solvent–dewaxed heavy paraffinic distillate, CAS No. 64742–65–0
Constituent 1
Constituent 2
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- with and without
- Metabolic activation system:
- rat liver microsomal
- Test concentrations with justification for top dose:
- 40,000 to 240,000 ug/plate
Controls
- Untreated negative controls:
- not specified
- Positive controls:
- not specified
Results and discussion
Test results
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
Any other information on results incl. tables
Plate assays were performed on all samples with and without rat liver microsomal metabolic activation. Suspension assays for paraffinic basestocks were also performed with a 20–minute pre–incubation with bacteria. Positive controls were also evaluated. No mutagenicity was demonstrated at any dose level. However, results are not conclusive for mutagenic potential because of the test materials insolubility, and the inability to demonstrate toxicity for the bacterial strains.
Applicant's summary and conclusion
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