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EC number: 213-697-3 | CAS number: 1003-03-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well-documented, scientifically acceptable study report OECD guideline was followed. No GLP study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Cyclopentylamine
- EC Number:
- 213-697-3
- EC Name:
- Cyclopentylamine
- Cas Number:
- 1003-03-8
- Molecular formula:
- C5H11N
- IUPAC Name:
- cyclopentanamine
- Reference substance name:
- cylcopentylamine
- IUPAC Name:
- cylcopentylamine
- Test material form:
- other: liquid
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dr . K . Thomae GmbH, 7950 Biberach
- Age at study initiation: 8 - 9 weeks
- Weight at study initiation: males 273 +/- 16.7 g and females 198 +/- 7.6 g.
- Housing: They were housed in groups of five in wire cages, type DIII, of Becker, without bedding with a day/night rhythm of 12 hours.
- Diet: KLIBA laboratory diet rat/mouse A 343 10-mm pellets
- Water: drinking water ad libitum during the post-exposure observation period
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24°C
- Humidity (%): 30-70%.
- Air changes (per hr): fully air-conditioned rooms
- Photoperiod (hrs dark / hrs light): 12 hours dark and 12 hours light
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- nose/head only
- Vehicle:
- air
- Details on inhalation exposure:
- The concentration of test group 1 (= 2.5 mg/L) was selected on the basis of the information available on the toxicity of the test substance; the remaining concentrations were selected in such a way that it was possible to determine an LC50.
A mixture of vapour and air was generated by means of a continuous infusion pump INFU 362 (INDIGEU Switzerland) and a glass evaporator with thermostat (BASF).
The supply air was conditioned via central air conditioning in such a way that there was a temperature of 19-25°C in the exposure apparatus. The inhalation mixture was offered to the animals for inhalation for 4 hours.
By means of an exhaust air system, the pressure ratios in the inhalation system were adjusted in such a way that there was a pressure slightly below the atmospheric pressure (negative pressure). This ensured that there was no contamination of the laboratory due to possible leakage from the inhalation chambers.
The nominal concentration was determined from the consumption of test substance and the air flow.
A gas chromatographical method was used for the quantitative determination of the vapour concentration.
The samples were taken up in about 45 mL DMF.
A calibration curve was prepared with the test substance in the solvent specified. The curve was calculated with a Hewlett Packard Computer Program SD 03A (curve adjustment: linear regression).
The concentrations in mg/L were calculated from the amounts determined analytically and the sample volumes of the inhalation atmosphere. - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 2.5 and 7.7 mg/L
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- After the exposure period, the surviving animals were observed for 14 resp. 18 days (2.5 mg/L).
The body weight of the animals was checked before the beginning of the test, after 7 days and at the end of the observation period. Clinical findings were generally recorded several times during exposure and at least once each workday during the post-exposure observation period. A check for mortalities was made daily.
At the end of the observation period, the surviving animals were sacrificed with CO2 and were subjected to a gross-pathological examination like all other animals which had died before.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- ca. 7.7 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- 2.5 mg/L: no deaths
7.7 mg/L: 4/10 - Clinical signs:
- other: During exposure: eyelid closure, accelerated, irregular, dragging to intermittently breathing; partly gasping; anemic aspect; watery nasal and eye secretion, salivation. After exposure: unsteady, staggering till shaking gait accelerated, irregular, draggi
- Body weight:
- Mean body weights for male animals: at study start 273 g, after 14 days 312 g
Mean body weights for female animals: at study start 198 g, after 14 days 220 g - Gross pathology:
- Animals that died: congestive hyperemia
Sacrificed animals: nothing abnormal detected
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.